New platinum–oxicam complexes as anti-cancer drugs. Synthesis, characterization, release studies from smart hydrogels, evaluation of reactivity with selected proteins and cytotoxic activity in vitro

Tamasi, Gabriella; Casolaro, Mario; Magnani, Agnese; Sega, Alessandro; Chiasserini, Luisa; Messori, Luigi; Gabbiani, Chiara; Valiahdi, Seied Mojtaba; Jakupec, Michael A.; Keppler, Bernhard K.; Hursthouse, Michael B.; Cini, Renzo

doi:10.1016/j.jinorgbio.2010.03.010

Cited by 50 publications

(26 citation statements)

References 56 publications

(65 reference statements)

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“…Our research interest is to develop hydrogel platforms based on α-amino acid residues to release drugs to the target site. The proposed hydrogels containing carboxyl acid moieties represent a challenge for their ability to form complex species of different bonding strenght for metal-based drugs [22,24,26] to be implanted or injected, as addressed by the controlled release community [52,53]. The present study is to focus on the release of the liable Pt(II)-complexed species for the chemotherapy of solid tumors.…”

Section: Discussionmentioning

confidence: 99%

Multiple Stimuli-Responsive Hydrogels for Metal-Based Drug Therapy

Casolaro

2012

Polymers

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A series of homopolymeric and copolymeric hydrogels containing the N-isopropylacrylamide and vinyl monomers with α-amino acid (L-valine and L-phenylalanine) residues have been synthesized and their swelling properties were evaluated under different external stimulations. The hydrogels, obtained with different cross-linking agents (EBA and PEG-DA), have shown unique properties such as biocompatibility in addition to the stimuli-responsive characters. These 'smart' hydrogels exhibit single or multiple stimuli-responsiveness which could be used in biomedical applications, including controlled drug delivery. This article focuses on recent developments dealing with the delivery of metal-based drug (cisplatin, lithium) from the stimuli-responsive hydrogels proposed as platforms for cancer and bipolar disorder therapies.

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Section: Discussionmentioning

confidence: 99%

Multiple Stimuli-Responsive Hydrogels for Metal-Based Drug Therapy

Casolaro

2012

Polymers

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“…Coordination complexes could offer many advantages over the ligand or metal itself, like an intrinsic high biological activity, a better solubility in biological fluids and a superior transport process through the cell membranes. [60,61] One of the most intriguing questions regarding biological activity of putative anticancer agents is their possible mechanism(s) of action. It could be assumed that the enzyme cyclooxygenase-2 is the main target of the selective NSAID meloxicam and (possibly) of its metal complexes.…”

Section: Long-term Experimentsmentioning

confidence: 99%

3d metal complexes with meloxicam as therapeutic agents in the fight against human glioblastoma multiforme and cervical carcinoma

Dyakova

Culiță

Zhivkova

et al. 2015

Biotechnology & Biotechnological Equipment

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The aim of our study was to evaluate the influence of selective non-steroidal anti-inflammatory drug meloxicam and its metal (Cu(II), Zn(II), Co(II), Ni(II)) complexes on the viability and proliferation of cultured humancarcinoma of the uterine cervix (HeLa) and glioblastoma multiforme (8MGBA) cells. The investigations were performed by short-term (24 hÀ96 h, with monolayer cultures) and long-term (16 d, with three-dimensional colonies of cancer cells) experiments by using methods with different molecular/cellular targets and mechanisms of action, such as thiazolyl blue tetrazolium bromide (MTT) test, neutral red uptake cytotoxicity assay, crystal violet staining, double staining with acridine orange and propidium iodide, alkaline version of single cell gel electrophoresis (comet assay) and colony-forming technique. The obtained results revealed that the application of the examined compounds at concentrations ranging from 5 mg/mL to 500 mg/mL induced cytopathological changes, including DNA damages in the treated cells and a significant decrease of their viability and proliferation in a time-and concentration-dependent manner. Metal complexes were found to have a more pronounced cytotoxic/cytostatic effect, when compared to their ligand meloxicam.

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“…Therefore, diVerent Pd complexes with promising activity against varying kinds of tumor cell lines have been synthesized and tested over years (Budzisz et al 2004;Abu-Surrah et al 2008;Ruiz et al 2008;Eryazici et al 2008;Divsalar et al 2010;Al-Masoudi et al 2010;Tamasi et al 2010 (Guney et al 2010). Their chemical structures are illustrated in Fig.…”

Section: Introductionmentioning

confidence: 99%