Release of propranolol hydrochloride from matrix tablets containing hydroxypropylmethylcellulose K4M and carbopol 974

Pérez-Marcos, B.; Ford, James L.; Armstrong, David J.; Elliott, Paul I. P.; Rostron, C.; Hogan, John E.

doi:10.1016/0378-5173(94)90348-4

Cited by 40 publications

(21 citation statements)

References 17 publications

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“…Thermal AnalysissDifferential scanning calorimetry was employed to measure the water distribution of gels containing 10, 20, 30 or 40% w/v HPMC, carbopol, or their 1:1 mixtures prepared as described under cloud points above, using the method of Perez-Marcos et al 8 A Perkin-Elmer (Beaconsfield, UK) differential scanning calorimetor (model DSC 7) with automatic cooling facilities was used, controlled by a Perkin-Elmer TAC 7. The equipment was calibrated using indium and zinc.…”

Section: Methodsmentioning

confidence: 99%

“…carbopol, are influenced to a great extent by the pH. 7 Perez-Marcos et al 8 have already demonstrated the feasibility of using matrices containing HPMC and carbopol for sustaining the release of propranolol hydrochloride using distilled water as the dissolution medium. This paper reports on the effects of varying the dissolution media on the release of propranolol hydrochloride from matrices of HPMC K4M, carbopol 974, or their mixtures.…”

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confidence: 98%

“…The dissolution of these tablets into water has previously been reported. 8 Dissolution TestingsDissolution was studied using the USP 1 basket method, rotating at 100 rpm, in 1000 mL of dissolution medium maintained at 37°C (Pharmatest GmbH, Germany). Propranolol was determined spectrophotometrically at 288 nm using a Hewlett-Packard HP8452A Diode array.…”

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confidence: 99%

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Influence of pH on the Release of Propranolol Hydrochloride from Matrices Containing Hydroxypropylmethylcellulose K4M and Carbopol 974

Pérez-Marcos

Ford

Armstrong

et al. 1996

Journal of Pharmaceutical Sciences

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The dissolution of propranolol hydrochloride from matrices containing hydroxypropylmethylcellulose K4M (HPMC K4M) and carbopol 974 has been investigated using 0.1 M hydrochloric acid or phosphate buffer at pH 4.5 or pH 7.5. In 0.1 M hydrochloric acid, HPMC K4M predominantly controlled release since carbopol has a low solubility at this pH. As the pH increased, the carbopol became increasingly ionized and interacted with propranolol hydrochloride to form an insoluble complex which retarded the release of the drug. In addition, the nature of the interaction between carbopol 974 and HPMC K4M altered. DSC and viscometric studies indicated that the two polymers contributed synergistically to the gel network at pH 7.5. Thus at pH 7.5 polymers contributed to matrix integrity and to the control of drug release.

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 98%

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Influence of pH on the Release of Propranolol Hydrochloride from Matrices Containing Hydroxypropylmethylcellulose K4M and Carbopol 974

Pérez-Marcos

Ford

Armstrong

et al. 1996

Journal of Pharmaceutical Sciences

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“…The retardant effects of Carbopol \ polymers on drug release from solid dosage forms has been well documented in the pharmaceutical literature (25)(26)(27)(28)(29). Carbopol \ polymers swell in neutral media owing to the ionization of carboxylic acid groups resulting in the formation of a viscous hydrogel that retards drug diffusion from the swollen polymer matrix.…”

Section: Dissolution Analysis With Ph Changementioning

confidence: 98%

Targeted Intestinal Delivery of Supersaturated Itraconazole for Improved Oral Absorption

et al. 2008

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“…Hydroxypropyl methylcellulose (HPMC) or methocel K100M CR is used frequently as a ratecontrolling polymer in matrix tablets. HPMC offers the advantages of being non-toxic and relatively inexpensive; it can be compressed directly into matrices and is available in different chemical substitution and hydration rates and viscosity grades [6][7] .…”

Section: Introductionmentioning

confidence: 99%

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2011

IJPSR

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In the present study, an attempt has been made to evaluate the effect of hydrophilic polymers on the release profile of drug from matrix system. Salbutamol sulphate, an anti-asthmatic agent, was used as a model drug to evaluate its release characteristics from different matrices. Matrix tablets of salbutamol sulphate were prepared by direct compression process using methocel K100M CR polymer. Release kinetics of salbutamol sulphate from these sustained release matrices in distilled water using USP paddle method with sinker for 8 hours were studied. Statistically significant differences were found among the drug release profile from different formulations. Higher polymer content (70%) in the matrix decreased the rate of the drug due to increased tortuosity and decreased porosity. At lower polymeric level (30%), the rate of drug release was elevated. The release mechanism was explored and explained with zero order, first order, Higuchi and Korsmeyer equations. The results generated in this study showed that the profile and kinetics of drug release were functions of polymer type, polymer level and physico-chemical properties of the drug.

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Release of propranolol hydrochloride from matrix tablets containing hydroxypropylmethylcellulose K4M and carbopol 974

Cited by 40 publications

References 17 publications

Influence of pH on the Release of Propranolol Hydrochloride from Matrices Containing Hydroxypropylmethylcellulose K4M and Carbopol 974

Influence of pH on the Release of Propranolol Hydrochloride from Matrices Containing Hydroxypropylmethylcellulose K4M and Carbopol 974

Targeted Intestinal Delivery of Supersaturated Itraconazole for Improved Oral Absorption

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