Release of phenolics compounds from  Rubus idaeus  L. dried fruits and seeds during simulated  in vitro  digestion and their bio-activities

Qin, Yin; Wang, Lu; Liu, Yufeng; Zhang, Qunying; Li, Yongxia; Wu, Zhenqiang

doi:10.1016/j.jff.2018.04.046

Cited by 72 publications

(65 citation statements)

References 37 publications

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“…Meanwhile, it can be found that there also existed high contents of some invididual phenolic compounds in SE, such as gallic acid (127.15 ± 3.21 µg/g DW), procyanidin C3 (29.12 ± 0.11 µg/g DW) and ellagic acid (48.32 ± 0.23 µg/g DW), which showed that SE may be used as a good food ingredient enriched in phenolic compounds. Qin et al (2018) have confirmed that high levels of gallic acid and ellagic acid existing in the form of bound phenolics were found in raspberry fruit and seed extracts, which was consistent with the results of our study [13].…”

Section: Hplc-esi-hr-qtof-ms/ms Characterization and Quantification Osupporting

confidence: 92%

“…The correlation co-efficient analysis results between the phenolic contents at different concentrations and antioxidant activities of the three extracts clearly verified that there was a good correlation between these two parameters (DPPH vs. TPC, r = −0.807, p < 0.01; ABTS vs. TPC, r = −0.875, p < 0.01; OH − vs. TPC, r = −0.792, p < 0.01), suggesting that the phenolic compounds significantly contributed to the antioxidant activities of three samples extracts. Qin et al (2018) reported that the antioxidant activities of raspberry fruits and seeds extracts were strongly correlated with the released phenolic contents during in vitro digestion [13]. Wang et al (2019) also confirmed that the released bound phenolics of raspberry leaves and seeds treated with different methods were responsible for their antioxidant activities [14].…”

Section: Antioxidant Activitiesmentioning

confidence: 82%

“…Raspberry seeds are also good raw materials for food industries, but there is little research focused on the its phyto-constituents and bio-activities [12]. Qin et al (2018) have reported that raspberry fruits and seeds include large amounts of anti-oxidative bound phenolics. During in vitro digestion, the released bound phenolics (non-extractable) possessed antioxidant activities and the inhibitory effect of α-glucosidase [13].…”

mentioning

confidence: 99%

“…Qin et al (2018) have reported that raspberry fruits and seeds include large amounts of anti-oxidative bound phenolics. During in vitro digestion, the released bound phenolics (non-extractable) possessed antioxidant activities and the inhibitory effect of α-glucosidase [13]. Moreover, different extraction methods for releasing the non-extractable phenolics in the leaves and seeds of raspberry have been investigated in our previous work [14].…”

mentioning

confidence: 99%

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HPLC-ESI-qTOF-MS/MS Characterization, Antioxidant Activities and Inhibitory Ability of Digestive Enzymes with Molecular Docking Analysis of Various Parts of Raspberry (Rubus ideaus L.)

Liu

Qin

et al. 2019

Antioxidants

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The anti-oxidative phenolic compounds in plant extracts possess multiple pharmacological functions. However, the phenolic characterization and in vitro bio-activities in various parts of raspberry (Rubus idaeus L.) have not been investigated systematically. In the present study, the phenolic profiles of leaves (LE), fruit pulp (FPE), and seed extracts (SE) in raspberry were analyzed by HR-HPLC-ESI-qTOF-MS/MS method, and their antioxidant activities and digestive enzymes inhibitory abilities were also investigated. The molecular docking analysis was used to delineate their inhibition mechanisms toward type II diabetes related digestive enzymes. Regardless of LE, FPE, or SE, 50% methanol was the best solvent for extracting high contents of phenolic compounds, followed by 50% ethanol and 100% methanol. The LE of raspberry displayed the highest total phenolic content (TPC) and total flavonoid content (TFC). A total of nineteen phenolic compounds were identified. The quantitative results showed that gallic acid, ellagic acid, and procyanidin C3 were the major constituents in the three extracts. The various parts extracts of raspberry all exhibited the strong antioxidant activities, especially for LE. Moreover, the powerful inhibitory effects of the three extracts against digestive enzymes (α-glucosidase and α-amylase) were observed. The major phenolic compounds of the three extracts also showed good inhibitory activities of digestive enzyme in a dose-dependent manner. The underlying inhibitory mechanisms of the main phenolic compounds against digestive enzymes were clarified by molecular docking analysis. The present study demonstrated that the various parts of raspberry had strong antioxidant activities and inhibitory effects on digestive enzymes, and can potentially prevent oxidative damage or diabetes-related problems.

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Section: Hplc-esi-hr-qtof-ms/ms Characterization and Quantification Osupporting

confidence: 92%

Section: Antioxidant Activitiesmentioning

confidence: 82%

mentioning

confidence: 99%

mentioning

confidence: 99%

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HPLC-ESI-qTOF-MS/MS Characterization, Antioxidant Activities and Inhibitory Ability of Digestive Enzymes with Molecular Docking Analysis of Various Parts of Raspberry (Rubus ideaus L.)

Liu

Qin

et al. 2019

Antioxidants

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“…Since the amount and position of hydroxyl groups in flavonoids regulate their α-amylase inhibitory ability [34], flavonoids in husk pigment may undergo structural changes during digestion. In the light of a previous study [44], the inhibition toward the α-glucosidase activity of raspberry dried seeds was improved in simulated small intestinal digestion, suggesting that the digestive progress is beneficial for phenolic compounds to play a hypoglycemic function.…”

Section: Effect Of Digestion On the Hypoglycemic Ability Of Pigmentsmentioning

confidence: 70%

Functional Components, Antioxidant Activity and Hypoglycemic Ability Following Simulated Gastro-Intestinal Digestion of Pigments from Walnut Brown Shell and Green Husk

Sun

Zeng

et al. 2019

Antioxidants

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To assess the effects of digestion on the functional components of walnut pigment and their bioactivities, we developed an in vitro model simulating gastro-intestinal digestion. Results showed an increase in the contents of flavonoids and conjugated phenols (with retention rates higher than 100%) in husk pigment after digestion. The lowest of the 2,2 -azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging abilities was reached in the group with the minimum flavonoid content after digestion. Close correlation was observed between free phenol content and total reducing power, as the reducing power among different groups of husk pigment was in consistent with free phenols changes. The inhibitory effect of walnut pigment on α-amylase with/without digestion enzyme was similar. However, shell pigment showed improved inhibitory effect on α-glucosidase activity, with an increased inhibitory rate of 5.42%. In general, the antioxidant activity and hypoglycemic ability of walnut pigment were prone to chemical and enzymatic changes during simulated digestion, which were also related to the alteration of flavonoids and phenols.

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Preliminary Studies on the Effect of Simulated Digestion on the Antioxidant Activity of Monoterpenes

Wojtunik-Kulesza

Kasprzak-Drozd

2022

Chemistry & Biodiversity

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One of several possible ways of predicting substance bioactivity under in vivo conditions is through simulated studies based on conditions comparable to those within the organism. Having regards to pH and digestive enzymes, such an approach is through simulated digestion. Simulated studies allow gaining an understanding of physiological conditions and a prediction of compound behavior. The presented studies are based on simulated digestion (SD) to which selected monoterpenes (γ‐terpinene, α‐terpinene, α‐phellandrene, carvone, menthone, isopulegol, α‐pinene, β‐pinene, terpinene‐4‐ol, linalool, eucalyptol, p‐cymene, citral, citronellal) have been subjected. The procedure included changes pH (2.0 and 8.5) and digestive enzymes (pepsine in gastric stage and pancreatin in duodenal stage) to better understand what goes on within the gastro‐intestinal tract. The changes were observed for gastric and duodenal stages, as well as for two phases: oil and water. Obtained results revealed both positive and negative influence of gastrointestinal conditions on monoterpenes antioxidant activity. However, positive impact prevailed (γ‐terpinene, citral, eucalyptol, isopulegol, α‐pinene). The differentiation in activity can be explained by solubility in oil/water phases and the biotransformation of studied compounds.

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Release of phenolics compounds from Rubus idaeus L. dried fruits and seeds during simulated in vitro digestion and their bio-activities

Cited by 72 publications

References 37 publications

HPLC-ESI-qTOF-MS/MS Characterization, Antioxidant Activities and Inhibitory Ability of Digestive Enzymes with Molecular Docking Analysis of Various Parts of Raspberry (Rubus ideaus L.)

HPLC-ESI-qTOF-MS/MS Characterization, Antioxidant Activities and Inhibitory Ability of Digestive Enzymes with Molecular Docking Analysis of Various Parts of Raspberry (Rubus ideaus L.)

Functional Components, Antioxidant Activity and Hypoglycemic Ability Following Simulated Gastro-Intestinal Digestion of Pigments from Walnut Brown Shell and Green Husk

Preliminary Studies on the Effect of Simulated Digestion on the Antioxidant Activity of Monoterpenes

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