Release of NT-pro brain natriuretic peptide in children before and after adenotonsillectomy

Oran, Bülent; Öztürk, Kayhan; Çimen, Derya; Vatansev, Hüsamettin; Bulut, Serap; Arslan, Derya

doi:10.1016/j.ijporl.2013.01.007

Cited by 10 publications

(12 citation statements)

References 12 publications

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“…19 Increased level of BNP and improvement after T&A was reported in children with SDB with or without NE. [20][21][22][23] Our results support these findings because BNP levels in our study group normalized after T&A.…”

Section: Commentsupporting

confidence: 88%

Adenotonsillectomy Normalizes Hormones and Urinary Electrolytes in Children With Nocturnal Enuresis and Sleep-Disordered Breathing

Kovačević

Wolfe‐Christensen

et al. 2015

Urology

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Section: Commentsupporting

confidence: 88%

Adenotonsillectomy Normalizes Hormones and Urinary Electrolytes in Children With Nocturnal Enuresis and Sleep-Disordered Breathing

Kovačević

Wolfe‐Christensen

et al. 2015

Urology

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“…Kocabas et al 21) documented that children with OSA have been higher in body weight profile than the controls. In other previous studies, there was not a statistically significant difference between the ATH group and control group in the BMI profiles 7 , 22 , 23) . The present study found similar BMI profiles in ATH patients as those reported previously, and the difference in the BMI profiles between the ATH group and control group in this study was also similar to those reported previously.…”

Section: Discussionmentioning

confidence: 49%

“…N-terminal of probrain natriuretic peptide (NT-proBNP) is a cardiac hormone secreted by the ventricular myocardium in response to ventricular volume expansion and pressure overload. It has been effectively used to diagnose RV dysfunction 5 , 6 , 7) .…”

Section: Introductionmentioning

confidence: 99%

Effect of adenotonsillar hypertrophy on right ventricle function in children

et al. 2014

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PurposeChronic upper airway obstruction causes hypoxemic pulmonary vasoconstriction, which may lead to right ventricle (RV) dysfunction. Adenotonsillar hypertrophy (ATH) is the most common cause of upper airway obstruction in children. Therefore, we aimed to evaluate RV function in children with ATH.MethodsTwenty-one children (male/female, 15/6; mean age, 92.3¡¾39.0 months; age range, 4-15 years) with ATH and 21 healthy age- and gender-matched controls were included in this study. Tricuspid annular plane systolic excursion and RV myocardial performance index were measured by transthoracic echocardiography. Further, the plasma level of N-terminal of probrain natriuretic peptide (NT-proBNP), an indicator of RV function, was determined.ResultsThe snoring-tiredness during daytime-observed apnea-high blood pressure (STOP) questionnaire was completed by the patients' parents, and loud snoring was noted in the ATH group. The plasma NT-proBNP level was significantly higher in the ATH group than that in the controls (66.44±37.63 pg/mL vs. 27.85±8.89 pg/mL, P=0.001). The echocardiographic parameters were not significantly different between the groups.ConclusionWe were unable to confirm the significance of echocardiographic evidence of RV dysfunction in the management of children with ATH. However, the plasma NT-proBNP level was significantly higher in the ATH group than that in the control, suggesting that chronic airway obstruction in children may carry a risk for cardiac dysfunction. Therefore, more patients should be examined using transthoracic echocardiography. In addition, pediatricians and otolaryngologists should consider cardiologic aspects during the management of children with severe ATH.

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“…Moreover, they determined a significant decrease in NT-proBNP levels after adenotonsillectomy (86±32.6 pg/mL vs. 187.8±114 pg/mL, p=0.002). Oran et al (13) conducted a study on 20 children with ATH and 20 healthy children and found significantly higher pre-operative BNP levels in the ATH group (median BNP: 59.42 pg/mL vs. 37.79 pg/mL, p=0.03). Additionally, they observed a significant NT-ProBNP, N-terminal pro-brain natriuretic peptide; Min-Max, minimum-maximum.…”

Section: Discussionmentioning

confidence: 99%

Adenotonsiller Hipertrofi Olan Çocuklarda Adenotonsillektominin N-Terminal Pro-Beyin Natriüretik Peptid (NT-ProBNP) Düzeylerine Etkileri

Çeliker¹,

Yörük²,

Olgun³

et al. 2017

Van Med J

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Objective: Adenotonsillar hypertrophy (ATH) is the most common cause for obstructive sleep apnea syndrome (OSAS) and adenotonsillectomy is used in treatment. Children with OSAS experience cardiovascular complications. N-terminal pro-brain natriuretic peptide (NT-proBNP) is one of the critical markers used for cardiovascular diseases. The present study aimed to determine the effects of adenotonsillectomy on NTproBNP levels in patients with ATH. Materials and Methods:The study has been designed as a single center clinical study. Children with ATH were included in the study, who were complaining from snoring, breathing from the mouth and breathing pauses during sleep. Measurements of arterial oxygen saturation (SaO 2 ), complete blood cell count, routine biochemical blood tests, chest radiography, electrocardiography, and a complete ear, nose and throat examination were performed. Upper airway obstruction and snoring were graded. NT-proBNP level was measured quantitatively by electrochemiluminescence method. Adenotonsillectomy was performed by curettage and cold dissection methods under general anesthesia. Results:The study included 25 patients with ATH. Snoring or apnea was not observed in any of the patients at the post-operative 6 month. The median pre-and post-operative NT-proBNP levels were 10.01 pg/mL and 7.13 pg/mL, respectively and the difference was significant. There were no significant differences among the subgroups of gender, pre-operative snoring, preoperative apnea, tonsil size, and adenoid size regarding the difference of NT-ProBNP level between the postand pre-operative periods.

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Release of NT-pro brain natriuretic peptide in children before and after adenotonsillectomy

Cited by 10 publications

References 12 publications

Adenotonsillectomy Normalizes Hormones and Urinary Electrolytes in Children With Nocturnal Enuresis and Sleep-Disordered Breathing

Adenotonsillectomy Normalizes Hormones and Urinary Electrolytes in Children With Nocturnal Enuresis and Sleep-Disordered Breathing

Effect of adenotonsillar hypertrophy on right ventricle function in children

Adenotonsiller Hipertrofi Olan Çocuklarda Adenotonsillektominin N-Terminal Pro-Beyin Natriüretik Peptid (NT-ProBNP) Düzeylerine Etkileri

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