Release of C-Reactive Protein in Response to Inflammatory Cytokines by Human Adipocytes: Linking Obesity to Vascular Inflammation

Calabrò, Paolo; Chang, David; Willerson, James T.; Yeh, Edward T.H.

doi:10.1016/j.jacc.2005.06.017

Cited by 250 publications

(175 citation statements)

References 11 publications

(7 reference statements)

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“…CRP has been defined as a sensitive, but not specific, marker of inflammation. Several investigators reported that not only liver but also human atherosclerotic lesions, coronary artery smooth muscle cells, aortic endothelial cells and adipocytes express CRP [12][13][14] . This may indicate that persistent local production of CRP in atherosclerotic lesions, or coronary artery smooth muscle cells, leads to chronically evelated CRP levels of 0.1 to 0.3 mg/dL, which are detectable by hs-CRP assay and may be useful in predicting coronary risk [8][9][10] .…”

Section: Discussionmentioning

confidence: 99%

“…Epidemiological data have shown an independent association between elevated hs-CRP levels and coronary risk [9][10][11] . Recently, several investigators have found that human atherosclerotic lesions, coronary artery smooth muscle cells, aortic endothelial cells and adipocytes all express CRP [12][13][14] . Therefore, the persistent production of a small amount of CRP by atherosclerotic lesions and coronary artery smooth muscle cells may lead to a slight but chronic elevation in CRP levels.…”

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confidence: 99%

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Small,dense LDL and High-Sensitivity C-Reactive Protein (hs-CRP) in Metabolic Syndrome with Type 2 Diabetes Mellitus

Nakano

Kuboki

Matsumoto

et al. 2010

JAT

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Aim:To clarify the clinical significance of small,dense LDL (sLDL) in the metabolic syndrome associated with type 2 diabetes. Methods: One hundred and ten healthy non-diabetic and non-metabolic syndrome subjects (58 male / 52 female), 77 non-metabolic diabetic subjects (62/15), 58 non-diabetic metabolic subjects (25/33), and 46 metabolic diabetic subjects (29/17) were enrolled in this study. Results:The subjects with metabolic syndrome (both with and without type 2 diabetes) had significantly higher fasting blood glucose, total-cholesterol (C), LDL-C, triglyceride, sLDL-C and hs-CRP levels than non-metabolic and non-diabetic subjects. HDL-C levels were significantly decreased in the former compared to the latter. Among the metabolic syndrome subjects, those with type 2 diabetes had significantly higher fasting blood glucose, systolic blood pressure and hs-CRP values than those without diabetes. sLDL-C, LDL-C and hs-CRP were the highest and HDL-C was lowest in the metabolic syndrome with diabetes group. A multiple regression analysis revealed the most significant determinant of sLDL-C to be LDL-C, followed by HDL-C, total-C, metabolic syndrome, type 2 diabetes mellitus, and triglyceride. Conclusion: Metabolic syndrome is a significant determinant of the plasma sLDL-C level. Hs-CRP was the highest in the metabolic syndrome patients with type 2 diabetes. Therefore, type 2 diabetes may further increase the risk of coronary artery disease in the metabolic syndrome subjects through cardiovascular inflammation. J Atheroscler Thromb, 2010; 17:410-415.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Small,dense LDL and High-Sensitivity C-Reactive Protein (hs-CRP) in Metabolic Syndrome with Type 2 Diabetes Mellitus

Nakano

Kuboki

Matsumoto

et al. 2010

JAT

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“…25 The mechanisms of these associations are not clear, but in the case of obesity, a recent study showed that adipocytes themselves secrete CRP in response to inflammatory stimuli. 26 An analysis of the Women's Health Study population found that hs-CRP, besides correlating with components of the metabolic syndrome, added independent prognostic information on cardiovascular risk at all levels of severity of the syndrome. 9 In this same population, elevated hs-CRP predicted the development of type 2 diabetes.…”

Section: New Developments In C-reactive Protein and Risk Predictionmentioning

confidence: 99%

High-sensitivity C-reactive protein as a risk assessment tool for cardiovascular disease

Yeh

2005

Clin Cardiol

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Summary: Almost half of first cardiovascular events occur in individuals with no known risk factors. Attempts in the last decade to predict cardiovascular risk more accurately have led to the emergence of a novel risk factor, C-reactive protein (CRP), which has proved to be as good a risk predictor as lowdensity lipoprotein cholesterol. C-reactive protein is an index of inflammation that is now believed to promote directly all stages of atherosclerosis, including plaque rupture. As measured by high-sensitivity assays, high-sensitivity CRP (hs-CRP) also independently predicts recurrent events in patients with known coronary artery diseases. Recent evidence implicates hs-CRP, and thus inflammation, in the metabolic syndrome and diabetes mellitus, particularly in women. As a clinical tool for cardiovascular risk assessment, hs-CRP testing enhances information provided by lipid screening or global risk assessment. Statin therapy and other interventions can lower hs-CRP. Whether or not such reductions can prevent cardiovascular events is under investigation.

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“…Increased serum levels of markers of systemic inflammation e.g. interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) are usually associated with increased morbidity and mortality among type 2 diabetic patients (7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Inflammatory biomarkers and endothelial dysfunction among obese type 2 diabetic patients: A correlational study

Al-Dahr

2016

Electron J Gen Med

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Background:The vascular complications of diabetes mellitus impose a huge burden on the management of this disease. Inflammation is one of the major factors in the formation of endothelial dysfunction. Endothelial dysfunction is a major contributor to the complications of diabetes mellitus. Objective: The aim of the present study was to investigate the possible relationship between inflammation and endothelial dysfunction in obese type 2 diabetic patients. Materials and Methods: Forty obese type 2 diabetic patients (24 males and 16 females) with body mass index (BMI) ranged from 31 to 35 Kg/m2, non-smokers, free from respiratory, kidney; liver, metabolic and neurological disorders were recorded in this study. Their age ranged from 40 to 55 years were included in this study as the first group (A). While a forty non-diabetic subjects (23 males and 17 females) not suffering of any disease, their age ranged from 40 to 52 years were included in this study as the second group (B) and considered as a control group. Results: Diabetic patients showed significantly higher values of TNF-α, IL-6, CRP, HBA1c, ICAM-1, VCAM-1 and E-selectin in comparison to controls. Also, there was significant positive correlation between inflammatory and endothelial dysfunction biomarkers among obese diabetic patients. Conclusion: There was a strong association between elevated biomarkers of inflammation and endothelial dysfunction among type 2 diabetic patients.

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Release of C-Reactive Protein in Response to Inflammatory Cytokines by Human Adipocytes: Linking Obesity to Vascular Inflammation

Cited by 250 publications

References 11 publications

Small,dense LDL and High-Sensitivity C-Reactive Protein (hs-CRP) in Metabolic Syndrome with Type 2 Diabetes Mellitus

Small,dense LDL and High-Sensitivity C-Reactive Protein (hs-CRP) in Metabolic Syndrome with Type 2 Diabetes Mellitus

High-sensitivity C-reactive protein as a risk assessment tool for cardiovascular disease

Inflammatory biomarkers and endothelial dysfunction among obese type 2 diabetic patients: A correlational study

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