Release of allyl isothiocyanate from mustard seed meal powder entrapped in electrospun PLA–PEO nonwovens

Dai, Ruyan; Lim, Loong‐Tak

doi:10.1016/j.foodres.2015.08.029

Cited by 42 publications

(35 citation statements)

References 42 publications

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“…Neat PLA nanofibers (Figure 1(a)) presented a fiber diameter of 149 ± 23 nm. The addition of PEO (Figure 1(b)) increased the fiber diameter (304 ± 46 nm) owing to the free volume increase that occurs on blending the two polymers, which is attributed to the different segmental conformations between the PLA and PEO, reducing the PLA chain-chain packing [37]. As can be seen in Figures 1(c) and 1(d), the addition of GSE did not significantly affect the morphology and diameter of the nanofibers when compared with their counterparts (PLA and PLA/PEO nanofibers).…”

Section: Resultsmentioning

confidence: 99%

Biocompatible and Biodegradable Electrospun Nanofibrous Membranes Loaded with Grape Seed Extract for Wound Dressing Application

Locilento

Mercante

André

et al. 2019

Journal of Nanomaterials

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The development of nanofibrous membranes with tunable wettability, degradation, and biocompatibility is highly keen for biomedical applications, including drug delivery and wound dressing. In this study, biocompatible and biodegradable nanofibrous membranes with antioxidant properties were successfully prepared by the electrospinning technique. The membranes were developed using polylactic acid (PLA) and polyethylene oxide (PEO) as the matrix, with the addition of grape seed extract (GSE), a rich source of natural antioxidants. The nanofibrous membranes were thoroughly characterized both from the materials and from the biocompatibility point of view. PLA and PLA/PEO nanofibers showed high encapsulation efficiency, close to 90%, while the encapsulated GSE retained its antioxidant capacity in the membranes. In vitro release studies showed that GSE diffuses from PLA/GSE and PLA/PEO/GSE membranes in a Fickian diffusion manner, whose experimental data were well fitted using the Korsmeyer-Peppas model. Furthermore, a higher controlled release of GSE was observed for the PLA/PEO/GSE membrane. Moreover, culturing experiments with human foreskin fibroblast (HFF1) cells demonstrated that all samples are biocompatible and showed that the GSE-loaded PLA/PEO nanofibrous membranes support better cell attachment and proliferation compared to the PLA/GSE nanofibrous membranes, owing to the superior hydrophilicity. In summary, the results suggested that the GSE-loaded membranes are a promising topical drug delivery system and have a great potential for wound dressing applications.

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Section: Resultsmentioning

confidence: 99%

Biocompatible and Biodegradable Electrospun Nanofibrous Membranes Loaded with Grape Seed Extract for Wound Dressing Application

Locilento

Mercante

André

et al. 2019

Journal of Nanomaterials

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“…Polymer nanofibers have been largely used in applications ranging from biomedical applications such as in tissue engineering, regenerative medicine, and anti‐infective membranes to military and food industries. Moreover, they can be used to encapsulate and deliver natural antimicrobial active substances such as essential oils and phytoconstituents to replace synthetic ones, therefore, being of great interest to pharmaceutical and food products …”

Section: Introductionmentioning

confidence: 99%

Polystyrene bioactive nanofibers using orange oil as an ecofriendly solvent

Miranda

Mattoso

Bresolin

et al. 2018

J of Applied Polymer Sci

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Solution blow spun polystyrene (PS) nanofibers were produced from 20 to 30 wt % PS solutions using toluene (industrial solvent) and orange oil (green solvent). The latter being composed of D-limonene (97.06%) as determined by gas chromatography-mass spectroscopy. The rheological behavior and volatility of the solvents and polymer solutions were correlated with fiber morphology, accessed by scanning electron microscopy. Thermal analysis was used to determine the thermal behavior of fibers. The antimicrobial activity of orange oil was tested for potential applications of the spun mats in active food packaging. Results showed that the nanofibers spun from orange oil solutions had average diameters of 306 AE 74 nm as opposed to 441 AE 110 nm for toluene. Moreover, when compared with fiber spun from toluene solutions, orange oil yielded more flexible fibers with slightly lower contact angles and better antimicrobial properties due to the presence of residual oil confirmed by Fourier-transform infrared spectroscopy.

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“…10,11 Dai and Lim demonstrate the feasibility of entrapping mustard seed meal powder particles in nonwovens produced by electrospinning PLA-b-PEO blends into ultrafine fibers, as an antibacterial agent for controlled release. 12 Jie et al used the PEO-b-PLA copolymers to compare the kinetics of drug release for star-branched, tri-and di-block copolymers. The drug release profile showed that the release of paclitaxel from these polymers could be controlled over weeks.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Polymeric Micelles of Poly(Ethylene Oxide-b-Lactic Acid) and their Encapsulation With Lavender Oil

et al. 2016

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Nanoparticles comprised of the poly(ethylene oxide)-b-poly (lactic acid) diblock copolymer (PEO-b-PLA) with and without the incorporation of lavender oil were prepared by nanoprecipitation. Diblock copolymers based on a fixed PEO block (5 KDa ) and two different PLA segments (4.5 or 10 KDa ) were used. The morphology, encapsulation efficiency, essential oil-polymer interaction and the release kinetics of the active agent in the nanoparticles, were evaluated. The hydrodynamic radius of the nanoparticles determined by light scattering was affected by the size of the poly(lactic acid) (PLA) block. The lavender essential oil encapsulation efficiency (at a concentration of 0.4 μL mL -1 ) determined by UV-VIS spectroscopy was in the range of 70-75%. The in vitro release suggests that the polymeric barrier is able to control the oil release.

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Release of allyl isothiocyanate from mustard seed meal powder entrapped in electrospun PLA–PEO nonwovens

Cited by 42 publications

References 42 publications

Biocompatible and Biodegradable Electrospun Nanofibrous Membranes Loaded with Grape Seed Extract for Wound Dressing Application

Biocompatible and Biodegradable Electrospun Nanofibrous Membranes Loaded with Grape Seed Extract for Wound Dressing Application

Polystyrene bioactive nanofibers using orange oil as an ecofriendly solvent

Preparation of Polymeric Micelles of Poly(Ethylene Oxide-b-Lactic Acid) and their Encapsulation With Lavender Oil

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