Release Mechanisms for Polyelectrolyte Capsules

Geest, Bruno G. De; Sanders, Niek N.; Sukhorukov, Gleb B.; Demeester, Joseph; Smedt, Stefaan C. De

doi:10.1002/chin.200724277

Cited by 378 publications

(70 citation statements)

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“…It is also applicable to substrates of any shape, it is environmentally-friendly and it allows room temperature processing and low-cost manufacturing [25]. Polyelectrolyte multilayered films have therefore been considered for biomedical application such as capsules for drug delivery [26,27], immunosensing [28], regenerative neurobiology [29], antibacterial and anti fungal protection [30,31]. Despite its potential, LbL has not yet been translated for routine application in the manufacture of medical devices, and further research is required to demonstrate its practical value.…”

Section: Introductionmentioning

confidence: 99%

Functionalised nanoscale coatings using layer-by-layer assembly for imparting antibacterial properties to polylactide-co-glycolide surfaces

et al. 2015

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Article:Gentile, P., Frongia, M.E., Redon, M.C. et al. (4 more authors) (2015) Functionalised nanoscale coatings using Layer-by-Layer assembly for imparting antibacterial properties to polylactide-co-glycolide surfaces. Acta Biomaterialia.https://doi.org/10.1016/j.actbio.2015.04.009 eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse Unless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request. AbstractIn order to achieve high local biological activity and reduce the risk of side effects of antibiotics in the treatment of periodontal and bone infections, a localised and temporally controlled delivery system is desirable. The aim of this research was to develop a functionalised and resorbable surface to contact soft tissues to improve the antibacterial behaviour during the first week after its implantation in the treatment of periodontal and bone infections. Solvent-cast poly(D,L-lactide-coglycolide acid) (PLGA) films were aminolysed and then modified by Layer-by-Layer technique to obtain a nano-layered coating using poly(sodium4-styrenesulfonate) (PSS) and poly(allylamine hydrochloride) (PAH) as polyelectrolytes. The water-soluble antibiotic, metronidazole (MET), was incorporated from the ninth layer. Infrared spectroscopy showed that the PSS and PAH absorption bands increased with the layer number. The contact angle values had a regular alternate behaviour from the ninth layer. X-Ray Photoelectron Spectroscopy evidenced two distinct peaks, N 1s and S 2p , indicating PAH and PSS had been introduced. Atomic Force Microscopy showed the presence of polyelectrolytes on the surface with a measured roughness about 10 nm after 20 layers deposition.The drug release was monitored by Ultraviolet-visible spectroscopy showing 80% loaded-drug delivery in 14 days. Finally, the biocompatibility was evaluated in vitro with L929 mouse fibroblasts and the antibacterial properties were demonstrated successfully against the keystone periodontal bacteria Porphyromonas gingivalis, which has an influence on implant failure, without compromising in vitro biocompatibility. In this study, PLGA was successfully modified to obtain a localised and temporally controlled drug delivery system, demonstrating the potential value of LbL as a coating technology for the manufacture of me...

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Section: Introductionmentioning

confidence: 99%

Functionalised nanoscale coatings using layer-by-layer assembly for imparting antibacterial properties to polylactide-co-glycolide surfaces

et al. 2015

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“…[8] Therefore, numerous release mechanism have been incorporated within these capsules. Inherent to their polyionic nature, polyelectrolyte capsules are prone to ionic strength and pH.…”

Section: Engineering the Capsules To Release Biotherapeuticsmentioning

confidence: 99%

“…[6] While the polymeric shell is fully permeable to low molecular weight compounds such as ions and small drug molecules, they are impermeable to larger molecules. This property, schematically illustrated in Figure 1, renders polymeric multilayer capsules ideally suited for the encapsulation of biotherapeutics such as proteins, peptides, and nucleic acids like DNA, siRNA etc… [7][8][9] While the aqueous void of the capsules should provide physico-and bio-chemical stability to the molecules of interest, the capsule surface could be engineered in order to (1) target specific cell populations, (2) activate certain cell functions upon binding of the capsules to the cell surface or upon intracellular uptake, (3) release the capsule content at the required moment when reaching the target site or (4) upon a well-defined stimulus.…”

Section: Introductionmentioning

confidence: 99%

Polymeric multilayer capsules delivering biotherapeutics

Koker

Cock

Rivera-Gil

et al. 2011

Advanced Drug Delivery Reviews

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“…Loading of and release from polyelectrolyte capsules is not part of this discussion, and the readers are referred to the literature [194,195] .…”

Section: Drug Release Through Polymer Shellsmentioning

confidence: 99%

Why is the nanoscale special (or not)? Fundamental properties and how it relates to the design of nano-enabled drug delivery systems

Otto

Villiers

2013

Nanotechnology Reviews

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Why is the nanoscale special (or not) ?Fundamental properties and how it relates to the design of nano-enabled drug delivery systems Abstract: Nanoscience studies describe natural phenomena at the submicron scale. Below a critical nanoscale limit, the physical, chemical, and biological properties of materials show a marked departure in their behavior compared to the bulk. At the nanoscale, energy conversion is dominated by phonons, whereas at larger scales, electrons determine the process. The surface-to-volume ratio at the nanoscale is immense, and interfacial interactions are markedly more important than at the macroscopic level, where the majority of the material is shielded from the surface. These properties render the nanoparticles to be significantly different from their larger counterparts. Nano-enabled drug delivery systems have resulted from multidisciplinary cooperation aimed at improving drug delivery. Significant improvements in the thermodynamic and delivery properties are seen due to nanotechnology. Hybrid nanodelivery systems, i.e., membranes with nanopores that can gate stimuli-responsive drug release could be a future development. Nanotechnology will improve current drug delivery and create novel future delivery systems. The fundamental properties and challenges of nanodelivery systems are discussed in this review.

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Release Mechanisms for Polyelectrolyte Capsules

Abstract: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Cited by 378 publications

References 2 publications

Functionalised nanoscale coatings using layer-by-layer assembly for imparting antibacterial properties to polylactide-co-glycolide surfaces

Functionalised nanoscale coatings using layer-by-layer assembly for imparting antibacterial properties to polylactide-co-glycolide surfaces

Polymeric multilayer capsules delivering biotherapeutics

Why is the nanoscale special (or not)? Fundamental properties and how it relates to the design of nano-enabled drug delivery systems

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