Release characteristics of cisplatin chitosan microspheres and effect of containing chitin.

Nishioka, Yasuhiko; Kyotani, Shojiro; Okamura, Masashi; Miyazaki, Masako; Okazaki, Kazuichi; Ohnishi, Shunshiro; Yamamoto, Yasutake; Ito, Kenichi

doi:10.1248/cpb.38.2871

Cited by 91 publications

(31 citation statements)

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“…This may be explained on the basis that an increase in viscosity of the chitosan solution with increase in concentration prevents drug crystals from leaving the droplet. A study carried out by Nishioka et al [1990] also revealed that the cisplatin content increased with increasing chitosan concentration. Furthermore, Nishioka et al also proved that the incorporation of chitin in the carrier matrix increased the drug content.…”

Section: Properties Of Spray-dried Chitosan-tpp Microspheresmentioning

confidence: 90%

Preparation and characterization of drug-loaded chitosan-tripolyphosphate microspheres by spray drying

2005

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The present study reports on the preparation of chitosan-tripolyphosphate (TPP) microspheres by the spray-drying method using acetaminophen as a model drug substance. Chitosan-TPP microspheres were spherical and had a smooth surface. Perfectly spherical chitosan-TPP microparticles loaded with acetaminophen were obtained in the size range of 3.1-10.1 mm. Spray-dried chitosan-TPP microspheres were positively charged (zeta potential ranged from +18.4 to +31.8). The encapsulation efficiency of these microspheres was in the range of 48.9-99.5%. The swelling capacity of chitosan-TPP microspheres increased with increases in the molecular weight of chitosan and decreases with increasing volume of 1% wt/vol TPP solution used for the cross-linking reaction. The effect of chitosan concentration, drug loading, volume of TPP solution used for cross-linking, and chitosan molecular weight on surface morphology and drug release rate was extensively investigated. Microparticles with spherical shape and slower release rates were obtained from chitosan-TPP microspheres prepared using a higher concentration of chitosan, higher volume of TPP solution, a higher molecular weight chitosan and/or a higher drug loading. Most importantly, the drug release rate was mainly controlled by the chitosan-TPP matrix density and, thus, by the degree of swelling of the hydrogel matrix. Drug release from chitosan-TPP microspheres occurred via diffusion as the best fit for drug release was obtained using the Higuchi equation. Drug Dev. Res. 64:114-128, 2005.

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Section: Properties Of Spray-dried Chitosan-tpp Microspheresmentioning

confidence: 90%

Preparation and characterization of drug-loaded chitosan-tripolyphosphate microspheres by spray drying

2005

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“…[12][13][14] In the attempt to improve material properties used for metal adsorption or controlled drug-delivery, chitosan gel beads was chemically modified by homogeneous or heterogeneous crosslinking of linear chitosan chains with bifunctional reagent glutaric dialdehyde (GA) or ethylene glycol diglycidyl ether (EGDE). [15][16][17][18][19][20][21] Crosslinking can reduce the solubility of chitosan in aqueous solvents over a broad pH range, and increased resistance to chemical degradation or long-term biological degradation. GA and EGDE are, lately, not the preferred crosslinking agents due to their physiological toxicity.…”

Section: Introductionmentioning

confidence: 99%

Kinetic study of chitosan-tripolyphosphate complex reaction and acid-resistive properties of the chitosan-tripolyphosphate gel beads prepared by in-liquid curing method

Shyu

Lee

et al. 1999

J. Polym. Sci. B Polym. Phys.

208

114

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“…Chitosan microspheres crosslinked by glutaraldehyde was prepared for the sustained release of cisplatin and 5-fluorouracil. [13][14][15][16] However, the use of glutaraldehyde is undesirable because of its toxicity. Chitosan has also been used for the preparation of nontoxic polyelectrolytecomplex products with natural polyanions such as carboxymethylcellulose, alginic acid, dextran sulfate, heparin, xanthan etc., for the immobilization and release of drugs or proteins.…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Polyelectrolyte complexation for the preparation of gel beads and controlled release of anticancer drug. I. Effect of phosphorous polyelectrolyte complex and enzymatic hydrolysis of polymer

Shyu

Kuan

et al. 1999

J. Appl. Polym. Sci.

111

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Enzymic hydrolyzed chitosan was employed to prepare chitosan-tripolyphosphate and chitosan-polyphosphoric acid gel beads using a polyelectrolyte complexation method for the sustained-release of anticancer agent, 6-mercaptopurine (6-MP). pH responsive swelling ability, drug-release characteristics, and morphology of the chitosan gel bead depends on polyelectrolyte complexation mechanism and molecular weight of the enzymic hydrolyzed chitosan. The complexation mechanism of chitosan beads gelled in pentasodium tripolyphosphate or polyphosphoric acid solution was ionotropic crosslinking or interpolymer complex, respectively. The drug-release patterns of all chitosan gel beads in pH 6.8 seemed to be diffusional based, which might be in accordance with the Higuchi model, whereas release profiles of the chitosan-tripolyphosphate gel beads in pH 1.2 medium seemed to be non-Fickian diffusion controlled due to the swelling or matrix erosion of the beads. The rate of 6-MP releasing from chitosan-tripolyphosphate or chitosanpolyphosphoric acid gel matrix were significantly increased with the decreased molecular weight of enzymic hydrolyzed chitosan. However, the dissolution rates of 6-MP entraped in chitosan-tripolyphosphate and chitosan-polyphosphoric acid gel matrix were significantly slower than the dissolution rate of the original drug. These results indicate that the chitosan-polyphosphoric acid gel bead is a better polymer carrier for the sustained release of anticancer drugs in simulated intestinal and gastric juice medium than the chitosantripolyphosphate gel beads.

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Release characteristics of cisplatin chitosan microspheres and effect of containing chitin.

Cited by 91 publications

References 0 publications

Preparation and characterization of drug-loaded chitosan-tripolyphosphate microspheres by spray drying

Preparation and characterization of drug-loaded chitosan-tripolyphosphate microspheres by spray drying

Kinetic study of chitosan-tripolyphosphate complex reaction and acid-resistive properties of the chitosan-tripolyphosphate gel beads prepared by in-liquid curing method

Chitosan-Polyelectrolyte complexation for the preparation of gel beads and controlled release of anticancer drug. I. Effect of phosphorous polyelectrolyte complex and enzymatic hydrolysis of polymer

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