Release behavior of salicylic acid in supramolecular hydrogels formed by l-phenylalanine derivatives as hydrogelator

Stabilization Mechanism of Clarithromycin Tablets under Gastric pH Conditions

“…Recently however, some low-molecular-weight compounds have been reported to undergo gelation in water or organic solvent and are known as supramolecular gelators. [13][14][15][16] From this study, CAM could be classified as a supramolecular gelator under low pH conditions. Supramolecular gel is formed by entrapping solvents in a three-dimensional network structure created by entanglement of noncovalent interactions such as hydrogen bonds, van der Waals forces, p-p interaction, crystal/liquid bridges and electrostatic interaction.…”

“…[15][16][17] In the pharmaceutical field particularly, novel gelators are expected to be applicable to the development of novel drug delivery system formulations such as ointments, transdermal therapeutic systems and sustained release formulations. 13,14,18) More detailed investigation into the mechanisms of gel formation to measure the Fourier transform infrared spectroscopy or Raman spectroscopy can be expected to facilitate the development of novel drug delivery system formulations containing CAM.…”

Niosomes encapsulated in biohydrogels for tunable delivery of phytoalexin resveratrol

“…The observed behavior is similar to that reported by Cao and co-workers, who developed a supramolecular hydrogel based on tetraethylammonium 3-{[(2R)-2-(octadecylamino)-3-phenyl propanoyl]amino}butyrate, TC 18 PheBu, for salicylic acid release. 52 Specically, the drug release enhanced from 48.6% to 58.8% aer 10 h when the hydrogelator concentration was reduced from 8% w/w to 4% w/w. Moreover, we recently also reported the efficient encapsulation of nucleic acids in hybrid hydrogels made of N-protected phenylalanine (Fmoc-Phe-OH) and k-C. 53 The nucleic acid release was 80% and 100% aer 5 h when the k-C concentration was adjusted to 1% and 0.8%, respectively.…”

A pH-/thermo-responsive hydrogel formed from N,N′-dibenzoyl-l-cystine: properties, self-assembly structure and release behavior of SA

“…This can be attributed to the variation of supramolecular interactions in the gels at different pH conditions. 49 Somewhat interestingly, when the amount of SA released from the DBC hydrogel is plotted against the square root of time (within 10 h), a good linear correlation is displayed (Fig. 10b).…”