Niosomes encapsulated in biohydrogels for tunable delivery of phytoalexin resveratrol

Machado, Noelia D.; Fernández, Mariana A.; Häring, Marleen; Saldías, César; Díaz, David Díaz

doi:10.1039/c8ra09655d

Cited by 29 publications

(14 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Tinnakorn et al(2017) reported that the cholesterol existing in niosome results in increased targeted drug delivery to bacteria through binding to bacteria's lipid membrane(52). Consistent with that of Machado and Akbari, results of the present study indicate increased antibacterial activity in nanomaterial-encapsulated antibiotics(53,54). According toGupta et al (2018), there are various absorption and fusion mechanisms between the niosome and the bacterial wall that could result in increased targeted drug delivery(55).…”

supporting

confidence: 90%

Encapsulation and Characterization of Meropenem in Niosome Nanoparticles and Inhibitory Effects of Antibiofilm and Antibacterial on Methicillin and Vancomycin Resistant Strains of Staphylococcus Aureus

Shirin

Gharaghie

Beiranvand

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: We aim to assess the antibacterial and anti-biofilm properties of niosome-encapsulated meropenem. Methods: After isolating S. aureus isolates and determining their microbial sensitivity, their ability to form biofilms was examined using plate microtiter assay. Various formulations of niosome-encapsulated meropenem were prepared using the thin-film hydration method, Minimum Biofilm Inhibitory Concentration (MBIC) and Minimum Inhibitory Concentration (MIC) were determined, and biofilm genes expression was examined. Drug formulations’ toxicity effect on HDF cells were determined using MTT assay.Results: Out of the 162 separated Staphylococcus aureus, 106 were resistant to methicillin. 87 MRSA isolates were vancomycin-resistant, all of which could form biofilms. The F1 formulation of neoplastic meropenem with a size of 51.3 ± 5.84 and an encapsulation index of 84.86 ± 3.14 was detected, which prevented biofilm growth with a BDI index of 69% and reduced icaD, FnbA, Ebps biofilms’ expression with p ≤0.05 in addition to reducing MBIC and MIC by 4-6 times. Interestingly, F1 formulation of neoplastic meropenem indicated cell viability over 90% at all tested concentrations. Conclusions: Results of the present study indicate that niosome-encapsulated meropenem reduces the resistance of Staphylococcus aureus MRSA to antibiotics in addition to increasing its anti-biofilm and antibiotic activity, and could prove useful as a new strategy for drug delivery.

show abstract

supporting

confidence: 90%

Encapsulation and Characterization of Meropenem in Niosome Nanoparticles and Inhibitory Effects of Antibiofilm and Antibacterial on Methicillin and Vancomycin Resistant Strains of Staphylococcus Aureus

Shirin

Gharaghie

Beiranvand

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…On the other hand, literature from the drug delivery field dealing with bioactive compounds loaded in liposomes, core-shell liposomes, niosomes with or without being encapsulated within biopolymeric hydrogels [59,73,74] determine release profiles using dialysis methods in physiologically relevant buffers rather than in vitro digestion models.…”

Section: Setting the Scene: Review Of Colloidal Delivery Vehiclesmentioning

confidence: 99%

“…For instance, the Korsmeyer-Peppas and Weibull models predicted anomalous transport (rather than typical Fickian diffusion) of resveratrol suggesting specific interactions between niosomes and hydrogel matrices [74]. Therefore, fitting in vitro release or bioaccessibility kinetics data to relevant mathematical models (Table 1) is providing useful quantitative comparison between different delivery vehicles in order to predict in vivo release kinetics and the release mechanisms.…”

Section: Setting the Scene: Review Of Colloidal Delivery Vehiclesmentioning

confidence: 99%

Engineering oral delivery of hydrophobic bioactives in real-world scenarios

Sarkar

Mackie

2020

Current Opinion in Colloid & Interface Science

View full text Add to dashboard Cite

show abstract

“…There is a general consensus that the future for efficient resveratrol delivery is based on obtaining systems capable of overcoming the limitations of this compound. There are a few reports based on the use of different delivery systems for the photoprotection of RSV, such as, self-nanoemulsions, core-shell nanoparticles, cyclodextrin complexes, hydrogels and lipid-core nanocapsules [ 18 , 34 , 35 ]. For instance, Fan et al developed RSV-loaded zein encapsulated with bovine serum albumin-caffeic acid conjugated core-shell nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Preservation of the Antioxidant Capacity of Resveratrol via Encapsulation in Niosomes

Machado

Gutiérrez

Matos

et al. 2021

Foods

Self Cite

View full text Add to dashboard Cite

Resveratrol (RSV) is a natural polyphenol which produces several benefits to human health, being the trans-isomer the most bioactive. However, its systemic absorption is limited due to its low water solubility, that reduces the oral bioavailability, and its chemical instability (owing to the trans-cis RSV isomer conversion upon light irradiation). Thus, encapsulation of this bioactive compound is required to protect it from destructive environmental conditions. Here, trans-RSV was encapsulated in food grade nanovesicles formed by Tween 80 and Span 80, with or without the addition of dodecanol (Dod) as membrane stabilizer. The size and shape of niosomes were evaluated by microscopy (TEM) and light scattering. RSV was successfully encapsulated in the vesicular systems (49–57%). The effect of Dod in the membrane bilayer was evaluated on the RSV in vitro release experiments under simulated gastrointestinal conditions. The total antioxidant capacity of the encapsulated polyphenol was measured using radicals’ assays (DPPH and ABTS). The niosomes were able to maintain almost the total antioxidant capacity of encapsulated RSV, also preserved the ~85% of trans-RSV, thus offering considerable protection against high energy irradiation. These results make these systems suitable for different applications, particularly for photosensitive compounds.

show abstract

Niosomes encapsulated in biohydrogels for tunable delivery of phytoalexin resveratrol

Abstract: A series of biohydrogels were evaluated as potential soft delivery vehicles for the encapsulation and subsequent release of niosomes loaded with resveratrol (RSV).

Cited by 29 publications

References 65 publications

Encapsulation and Characterization of Meropenem in Niosome Nanoparticles and Inhibitory Effects of Antibiofilm and Antibacterial on Methicillin and Vancomycin Resistant Strains of Staphylococcus Aureus

Encapsulation and Characterization of Meropenem in Niosome Nanoparticles and Inhibitory Effects of Antibiofilm and Antibacterial on Methicillin and Vancomycin Resistant Strains of Staphylococcus Aureus

Engineering oral delivery of hydrophobic bioactives in real-world scenarios

Preservation of the Antioxidant Capacity of Resveratrol via Encapsulation in Niosomes

Contact Info

Product

Resources

About