Release behavior of copper ion in a novel contraceptive composite

Li, Juan; Suo, Jinping; Huang, Xiaosong; Ye, Chang; Wu, Xiaojuan

doi:10.1016/j.contraception.2007.04.010

Cited by 16 publications

(9 citation statements)

References 20 publications

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“…This new possibility is currently being explored in China by several companies and university centres to achieve more uniform and perhaps higher release rates of copper than currently occurs from unalloyed copper coils or sleeves [72][73][74] . Nanotechnology may be able to reduce the size of framed devices, and increase the effective release rates of copper, but its potential impacts on efficacy, safety, acceptability and continuation are yet to be defined and demonstrated.…”

Section: Nanotechnologymentioning

confidence: 97%

State-of-the-art of non-hormonal methods of contraception: III. Intrauterine devices

Sivin

Batar

2010

The European Journal of Contraception & Reproductive Health

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Since the 1959 revival of the IUD, non-hormonal devices have become the most widely used of all reversible contraceptives. Pregnancy rates of copper-releasing IUDs in current use range from approximately 0.5 to 1.5 per hundred continuing users in the first year, with somewhat lower annual pregnancy rates thereafter. Evidence-based research has been systematically conducted and translated into guidelines for eligibility criteria and problem management. Recent device research, beyond the T, Multiload and frameless devices has centred on improved designs such as U ,Y and Slimline shapes, or enhanced copper release, the latter through electrochemical effects or nanotechnology applications. Other IUD research foci concern devices that decrease bleeding and pain by releasing non-steroidal anti-inflammatory drugs. Yet other research lines indicate noncontraceptive benefits of copper intrauterine devices in protecting against endometrial cancer, and favourable risk-benefit analyses of IUD use by women at risk of or post HIV infection. IUD mechanisms of action and the relation of IUDs to pelvic infection and ectopic pregnancy are briefly reviewed. For our literature search we used Medline, Popline and Cochrane Library data bases, Google search, our personal files, and the references contained in articles in our files.

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Section: Nanotechnologymentioning

confidence: 97%

State-of-the-art of non-hormonal methods of contraception: III. Intrauterine devices

Sivin

Batar

2010

The European Journal of Contraception & Reproductive Health

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“…, 2006), the standards of quality control in the process of manufacturing may be difficult to guarantee. The novel filtering type IVD described in the current study has overcome these defects, because we can control the filtering effect and cupric ions releasing rate by adjusting the composition of the materials, such as the amount of pore‐making agents and copper salts (Li et al. , 2007a,b).…”

Section: Discussionmentioning

confidence: 99%

The contraceptive effect of a novel filtering‐type nano‐copper complex/polymer composites intra‐vas device on male animals

Chen¹,

Huang²,

Suo

et al. 2010

Int J of Andrology

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Contraceptive techniques which target vas deferens have been paid great attention for their good efficacy, safety and reversibility. We have made a filtering-type intra-vas device (IVD) using nano-copper complex/polymer composites. Twenty male adult Beagle dogs and 40 male rabbits were randomly assigned to four groups (sham-operation, IVD, reversal and vasectomy groups). Dogs' semen parameters, concentration of α-glucosidase, copper and zinc ions were tested pre-operation and 1, 3, 6 and 12 months post-operation. The pregnancy rates of the rabbits were evaluated by mating trials after the IVDs were implanted. The histology of testis, epididymides and vas deferens of the animals was examined using an electron microscope. Apoptosis of the cells in the testes, epididymides and vas deferens was detected by TUNEL method. There was no sperm in the semen of dogs, which had been inserted IVD and vasectomized at 1, 3, 6 and 12 months post-operation. The concentration of α-glucosidase in the IVD group, reversal group and sham-operation group was not significantly different between pre- and post-operation. The pregnancy rates of the female rabbits in the vasectomy, IVD and reversal groups were all zero, but the pregnancy rate in the reversal group, after taking out IVD, and that of the sham-operation group was 60% and 80%, respectively. The ultrastructures of the testes, epididymides and vas deferens of the male animals in the IVD group and sham-operation group were in normal ranges compared with the vasectomy group. The apoptosis of the cells in the testes, epididymides and vas deferens in the vasectomy group of both dogs and rabbits was obvious compared with the other groups. No significant changes in the quantities of copper and zinc ions were found in semen of the male dogs both pre- and post-operation. Our studies demonstrated that the filtering-type nano-copper complex/polymer composites intra-vas device may be an efficacious, safe and reversible male contraceptive device.

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“…In places with higher pressure, such as the exposure of the surface of Cu-IUD, copper wires or sleeves might be broken or fragmented after longterm corrosion, resulting in the failure of the Cu-IUD (11). The corrosion products and long-term release behavior of the novel composite after soaking in FBS for different time spans were studied previously (1)(2). It was shown that there were no other new elements, such as P, Cl, and Ca, appearing on the surface of the composite and no Cu 2 O formed after immersing in FBS for 1 year, indicating that the release channels would not be obstructed by the deposition of these composites and that the effectiveness of copper could be improved significantly.…”

Section: Figurementioning

confidence: 99%

“…Previous research revealed that burst release of cupric ions could be avoided and that the effective utility of cupric ions could be improved in this composite (1)(2). Although Suzuki et al (3) reported that the PVA derivative hydrogel was safe for clinical use owing to its biocompatibility, the biocompatibility of this complex composite needed to be tested before clinical usage.…”

mentioning

confidence: 97%