Relaxin stimulates osteoclast differentiation and activation

Ferlin, Alberto; Pepe, Anastasia; Facciolli, Arianna; Gianesello, Lisa; Foresta, Carlo

doi:10.1016/j.bone.2009.10.007

Cited by 59 publications

(65 citation statements)

References 31 publications

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“…Ferlin i wsp. przedstawili wyniki potwierdzające stymulujący wpływ relaksyny 2 na różnicowanie, przeżywalność i aktywację osteoklastów [40]. Najprawdopodobniej dochodzi do dodatniego sprzężenia zwrotnego między komórkami nowotworowymi a osteoklastami, komórki nowotworowe poprzez np.…”

Section: Wpływ Relaksyny 2 Na Inwazyjność Komórekunclassified

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Relaxin 2 – a pregnancy hormone involved in the process of carcinogenesis

Domińska¹

2013

Ginekol Pol

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Streszczenie Relaksyna 2 jest polipeptydem o budowie podobnej do insuliny i insulino-podobnych czynników wzrostu (IGFs). Hormon ten nie wchodzi jednak w interakcje z receptorami insulinowymi Słowa kluczowe: relaksyna 2 / nowotworzenie / LGR7 / LGR8 / Abstract Relaxin 2 is a polypeptide hormone structurally related to insulin and insulin-like growth factors (IGFs). However, it does not interact with insulin receptors and has a decidedly different biological properties. Relaxin 2 activates LGR 7 and LGR 8 relaxin receptors, that belong to the leucine-rich repeat-containing (LRR),

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Section: Wpływ Relaksyny 2 Na Inwazyjność Komórekunclassified

“…Najprawdopodobniej dochodzi do dodatniego sprzężenia zwrotnego między komórkami nowotworowymi a osteoklastami, komórki nowotworowe poprzez np. relaksynę 2 stymulują działanie komórek kościogubnych, które z kolei wytwarzają czynniki wzrostu stymulujące rozrost guza [39][40][41].…”

Section: Wpływ Relaksyny 2 Na Inwazyjność Komórekunclassified

Relaxin 2 – a pregnancy hormone involved in the process of carcinogenesis

Domińska¹

2013

Ginekol Pol

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“…Other studies investigated the relationship between microRNA (miRNA) and osteogenesis, particularly the modulation by peptide-15, an analog of the cell-binding domain of collagen (5). The research on osteoclasts investigated their role in the immune system (6), or the molecules involved in osteoclast differentiation (7). Some studies focused on the osteoclast behaviour on artificial substrates (8).…”

Section: Bone Structure and Bone Cell Biologymentioning

confidence: 99%

Orthopaedic Research in Italy: State of the Art

Cenni

Scioscia²,

Baldini

2011

Int J Immunopathol Pharmacol

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The most significant results in experimental and clinical orthopaedic research in Italy within the last three years have been primarily in major congenital diseases, bone tumors, regenerative medicine, joint replacements, spine, tendons and ligaments, The data presented in the following discussion is comparable with leading international results, highlighting Italian orthopaedic research excellemce as well as its shortcomings.There has been continued innovation in orthopaedic research over the past years. The advances in basic science, particularly in molecular and cell biology, in material science and in nanotechnology, has provided the tools for bone engineering, bone imaging and innovative methods for diagnosis and treatment of primitive and metastatic bone tumours. At this point, it seems necessary to examine to what extent are the limitations of these new orthopaedic techniques as well as the prevalent topics that should be explored and the position of the Italian orthopedic research on a global stage.

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“…Relaxin (Rln), a member of the insulin/Rln family of structurally related hormones, is related to collagen turnover, angiogenesis, and antifibrosis [3]. Additionally, Rln has been implicated in the differentiation, activation, and survival of osteoclasts [4]. Receptors for the Rln family peptides (Rxfps) include leucine-rich repeat containing G protein coupled receptor (LGR) 7, LGR 8, G-protein-coupled receptor (GPCR) 135, and GPCR 142; these have been renamed as Rxfp 1, 2, 3, and 4, respectively.…”

Section: Introductionmentioning

confidence: 99%