Relaxation effects of adrenomedullin in carbachol-precontracted rabbit internal anal sphincter

Abstract

This relaxant effect of adrenomedullin might lead to novel clinical applications of adrenomedullin for anorectal disorders with increased internal anal sphincter tonus, such as anal fissure.

Lack of nitrate tolerance in isosorbid dinitrate- and sodium nitroprusside-induced relaxation of rabbit internal anal sphincter

“…The IAS pressure has been found to display an overshoot phenomenon in the patients with chronic anal fissure [7,8] . A number of drugs and chemicals were studied to decrease basal and precontracted tonus of IAS in vitro [9][10][11][12][13][14] . It has been showed that some drugs such as glyceryl trinitrate (GTN) and isosorbide dinitrate (ISDN) as nitric oxide (NO) donor might be used in treatment of chronic anal fissure [15,16] .…”