Lack of nitrate tolerance in isosorbid dinitrate- and sodium nitroprusside-induced relaxation of rabbit internal anal sphincter

Koyuncu, Ayhan; Bağcıvan, İhsan; Saraç, Bülent; Aydın, Cengiz; Yıldırım, Seda; Sarıoğlu, Yusuf

doi:10.3748/wjg.14.4667

Cited by 1 publication

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References 34 publications

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“…In addition, recombinant hemoglobin 1.1 (rHb1.1) could be caused specific obliteration of NO-induced relaxation of the IAS [ 77 ]. However, nitrate tolerance did not develop in IAS SM in the previous study [ 78 ].…”

Section: Resultsmentioning

confidence: 73%

A systematic review of translation and experimental studies on internal anal sphincter for fecal incontinence

Kim

Lee

et al. 2022

Ann Coloproctol

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The complexity in the molecular mechanism of the internal anal sphincter (IAS) limits preclinical or clinical outcomes of fecal incontinence (FI) treatment. So far, there are no systematic reviews of IAS translation and experimental studies that have been reported. This systematic review aims to provide a comprehensive understanding of IAS critical role in FI. Previous studies revealed the key pathway for basal tone and relaxation of IAS in different properties as follows; calcium, Rho-associated, coiled-coil containing serine/threonine kinase, aging-associated IAS dysfunction, oxidative stress, renin-angiotensin-aldosterone, cyclooxygenase, and inhibitory neurotransmitters. Previous studies have reported improved functional outcomes of cellular treatment for regeneration of dysfunctional IAS, using various stem cells, but did not demonstrate the interrelationship between those results and basal tone or relaxation-related molecular pathway of IAS. Furthermore, these results have lower specificity for IAS-incontinence due to the included external anal sphincter or nerve injury regardless of the cell type. An acellular approach using bioengineered IAS showed a physiologic response of basal tone and relaxation response similar to human IAS. However, in both cellular and acellular approaches, the lack of human IAS data still hampers clinical application. Therefore, the IAS regeneration presents more challenges and warrants more advances.

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Section: Resultsmentioning

confidence: 73%

A systematic review of translation and experimental studies on internal anal sphincter for fecal incontinence

Kim

Lee

et al. 2022

Ann Coloproctol

View full text Add to dashboard Cite

show abstract

Lack of nitrate tolerance in isosorbid dinitrate- and sodium nitroprusside-induced relaxation of rabbit internal anal sphincter

Abstract: Y. Lack of nitrate tolerance in isosorbid dinitrate-and sodium nitroprusside-induced relaxation of rabbit internal anal sphincter.

Cited by 1 publication

References 34 publications

A systematic review of translation and experimental studies on internal anal sphincter for fecal incontinence

A systematic review of translation and experimental studies on internal anal sphincter for fecal incontinence

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