Relaxation effect of narirutin on rat mesenteric arteries via nitric oxide release and activation of voltage-gated potassium channels

Wong, Emily Sze-Wan; Li, Rachel Wai Sum; Li, Jingjing; Li, Renkai; Seto, Sai Wang; Lee, Simon Ming‐Yuen; Leung, George Pak Heng

doi:10.1016/j.ejphar.2021.174190

Cited by 5 publications

(2 citation statements)

References 33 publications

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“…It has potent antioxidant activity and is an antineoplastic and anti-inflammatory agent [ 24 ]. Narirutin is a disaccharide derivative that is ( S )-naringenin substituted by a 6- O -(6-deoxy-alpha- l -mannopyranosyl)-beta- d -glucopyranosyl moiety at position 7 via a glycosidic bond with a vasodilator effect; indeed, it has been shown to induce the release of nitric oxide and the activation of potassium channels in vascular muscle cells in rat mesenteric arteries [ 25 ]. The other extracted components are hesperidin, rutin, and p-cumaric acid; these molecules are still being studied with regard to their effects on human health; for example, their use is being tested as a supplement in people suffering from venous insufficiency [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

Host–Guest Complexes HP-β-CD/Citrus Antioxidants: Exploratory Evaluations of Enhanced Properties in Biodegradable Film Packaging

et al. 2023

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The aim of this work was to exploit the antioxidant potential of molecules recovered during the pectin purification process of citrus lemon waste and to encapsulate them in stable pectin films, with a view to a green and circular economy process. Antioxidant molecules were recovered during the pectin purification process, further recovering matter from the waste. Seven molecules were identified and quantified, and the antioxidant power of the mixture and its stability over time was evaluated. To improve the stability of the bioactive fraction, this was complexed with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD); indeed, this procedure increased their thermal stability from 120 °C up to 250 °C, as verified by thermogravimetry. Furthermore, the most promising complexes were studied under autoclave-like conditions (120 °C, 28 min) to simulate thermal sterilization. The antioxidants and HP-β-CD were combined in a pectin film, showing increased stability over time (up to three times) compared to uncomplexed antioxidants. This process represents a first step towards the development of applicable devices for the delivery of antioxidant molecules.

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Section: Resultsmentioning

confidence: 99%

Host–Guest Complexes HP-β-CD/Citrus Antioxidants: Exploratory Evaluations of Enhanced Properties in Biodegradable Film Packaging

et al. 2023

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“…Existing research has found that hesperidin intervention leads to favorable changes in endothelium-dependent microvascular reactivity by decreasing the concentrations of circulating inflammatory biomarkers (e.g., high-sensitivity C-reactive protein, serum amyloid A protein, and soluble E-selectin) and regulating nitric oxide bioactivity ( 50 , 51 ). Narirutin relaxes the vascular system by stimulating the phosphorylation of endothelial nitric oxide synthase and voltage-dependent potassium current in arterial smooth muscle cells ( 52 ). Accordingly, the effects of PTFC compounds on NAFLD-associated CVD are primarily attributed to the inhibition of systematic inflammation.…”

Section: Extension Of Pure Flavonoids Compounds Exerted From ...mentioning

confidence: 99%

The new exploration of pure total flavonoids extracted from Citrus maxima (Burm.) Merr. as a new therapeutic agent to bring health benefits for people

Ding

Wang²,

Pang³

et al. 2022

Front. Nutr.

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The peel and fruit of Citrus varieties have been a raw material for some traditional Chinese medicine (TCM). Pure total flavonoids from Citrus maxima (Burm.) Merr. (PTFC), including naringin, hesperidin, narirutin, and neohesperidin, have been attracted increasing attention for their multiple clinical efficacies. Based on existing in vitro and in vivo research, this study systematically reviewed the biological functions of PTFC and its components in preventing or treating liver metabolic diseases, cardiovascular diseases, intestinal barrier dysfunction, as well as malignancies. PTFC and its components are capable of regulating glycolipid metabolism, blocking peroxidation and persistent inflammation, inhibiting tumor progression, protecting the integrity of intestinal barrier and positively regulating intestinal microbiota, while the differences in fruit cultivation system, picking standard, manufacturing methods, delivery system and individual intestinal microecology will have impact on the specific therapeutic effect. Thus, PTFC is a promising drug for the treatment of some chronic diseases, as well as continuous elaborate investigations are necessary to improve its effectiveness and bioavailability.

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Narirutin Attenuates Cerebral Ischemia-Reperfusion Injury by Suppressing the TXNIP/NLRP3 Pathway

Luo,

Wang,

Liu

et al. 2023

Neurochem Res

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Relaxation effect of narirutin on rat mesenteric arteries via nitric oxide release and activation of voltage-gated potassium channels

Cited by 5 publications

References 33 publications

Host–Guest Complexes HP-β-CD/Citrus Antioxidants: Exploratory Evaluations of Enhanced Properties in Biodegradable Film Packaging

Host–Guest Complexes HP-β-CD/Citrus Antioxidants: Exploratory Evaluations of Enhanced Properties in Biodegradable Film Packaging

The new exploration of pure total flavonoids extracted from Citrus maxima (Burm.) Merr. as a new therapeutic agent to bring health benefits for people

Narirutin Attenuates Cerebral Ischemia-Reperfusion Injury by Suppressing the TXNIP/NLRP3 Pathway

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