The new exploration of pure total flavonoids extracted from Citrus maxima (Burm.) Merr. as a new therapeutic agent to bring health benefits for people

Abstract

The peel and fruit of Citrus varieties have been a raw material for some traditional Chinese medicine (TCM). Pure total flavonoids from Citrus maxima (Burm.) Merr. (PTFC), including naringin, hesperidin, narirutin, and neohesperidin, have been attracted increasing attention for their multiple clinical efficacies. Based on existing in vitro and in vivo research, this study systematically reviewed the biological functions of PTFC and its components in preventing or treating liver metabolic diseases, cardiovascular diseases, intestinal barrier dysfunction, as well as malignancies. PTFC and its components are capable of regulating glycolipid metabolism, blocking peroxidation and persistent inflammation, inhibiting tumor progression, protecting the integrity of intestinal barrier and positively regulating intestinal microbiota, while the differences in fruit cultivation system, picking standard, manufacturing methods, delivery system and individual intestinal microecology will have impact on the specific therapeutic effect. Thus, PTFC is a promising drug for the treatment of some chronic diseases, as well as continuous elaborate investigations are necessary to improve its effectiveness and bioavailability.

Berberine: Potential preventive and therapeutic strategies for human colorectal cancer

“…Irrefutably, herbal medicine and natural products play a vital role in the prevention and treatment of tumors and other systemic diseases 11,12 . Scientists have concluded that herbal medicine treats digestive diseases through inhibiting cell proliferation, inducing apoptosis, anti‐oxidation, and inhibiting inflammatory factors 13 .…”

“…10 Irrefutably, herbal medicine and natural products play a vital role in the prevention and treatment of tumors and other systemic diseases. 11,12 Scientists have concluded that herbal medicine treats digestive diseases through inhibiting cell proliferation, inducing apoptosis, anti-oxidation, and inhibiting inflammatory factors. 13 Further, herbal medicine and natural products reduce the incidences of tumors, limit recurrence and metastasis, increase the efficacy of chemotherapy drugs, and modulate immune.…”

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