Relative risk of mesothelioma associated with different levels of exposure to asbestos.

Tuomi, Timo; Huuskonen, Matti S.; Virtamo, Matti; Tossavainen, Antti; Tammilehto, L.; Mattson, K.; Lahdensuo, A; Mattila, Jouni; Karhunen, Pekka J.; Liippo, K.; Tala, E

doi:10.5271/sjweh.1686

Cited by 69 publications

(17 citation statements)

References 16 publications

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“…Thus, although a wide variety of analytic results have been reported from different laboratories (10,(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25), it is impossible to determine, without a properly selected reference group analyzed in the same laboratory, whether true elevations of fiber and body counts exist in a population of subjects with mesothelioma.…”

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confidence: 96%

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Mineral fiber content of lungs in patients with mesothelioma seeking compensation in Québec.

Dufresne¹,

Bégin²,

Churg³

et al. 1996

Am J Respir Crit Care Med

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Asbestos fibers (AF) and ferruginous bodies (FB) in lung parenchyma from 50 workers seeking compensation from the Workers' Compensation Board of Québec for pleural or peritoneal mesothelioma were analyzed using transmission electron microscopy (TEM) equipped with energy-dispersive spectrometer (EDS) and phase-contrast microscopy (PCM). These workers had been occupationally exposed in mining and milling activities (12 were from Asbestos Township and 11 from Thetford Mines) and 27 were from other types of industry (asbestos factory, shipyard, etc.). For comparison, analyses of lung tissue at autopsy were done in a group of 49 subjects from a reference population. A 95% confidence interval upper limit of 540 AF < 5 microns/mg and a 95% confidence interval upper limit of 161 AF > or = 5 microns/mg dried lung tissue were found for the reference population. Similarly, a concentration of FB of 142 FB/g constituted the upper limit of detectable FB in the lungs of the reference population. Forty-eight of the 50 workers with mesothelioma had either a ferruginous body or total asbestos fiber count greater than the 95% confidence interval for the reference population; the remaining two had amosite and/or crocidolite concentrations greater than the 95% confidence interval for the reference population. The fiber types were different in the three groups, with the lungs of workers from Thetford Mines containing only chrysotile and tremolite, those from Asbestos Township containing chrysotile, tremolite, amosite, and crocidolite, and those in other industries containing largely amosite and crocidolite. We conclude that in this population of workers seeking compensation for mesothelioma, fiber analysis confirmed occupational asbestos exposure in every case. The fiber types responsible for the tumors are probably different in the three different groups.

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confidence: 96%

“…The relative risk of mesothelioma in relation to lung content of asbestos fibers has been estimated in several studies (7)(8)(9)(10)(11)(12)(13).…”

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confidence: 99%

Mineral fiber content of lungs in patients with mesothelioma seeking compensation in Québec.

Dufresne¹,

Bégin²,

Churg³

et al. 1996

Am J Respir Crit Care Med

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“…In case-control studies, statistically increased risks of mesothelioma have been associated with amphibole fibre levels exceeding 1.0×10 6 fibres (>1 µm)·g -1 dry lung, 0.1-0.2×10 6 fibres (>5 µm)·g -1 dry lung or 0.3-1.0×10 6 fibres (>10 µm)·g -1 dry lung [18][19][20].…”

Section: Malignant Mesotheliomamentioning

confidence: 99%

Guidelines for mineral fibre analyses in biological samples: report of the ERS Working Group. European Respiratory Society

Vuyst¹,

Karjalainen²,

Dumortier³

et al. 1998

Eur Respir J

151

107

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aaAsbestos comprises a group of six hydrated silicate minerals capable of forming very thin fibres: chrysotile, crocidolite, amosite, anthophyllite, tremolite and actinolite [1]. Chrysotile belongs to the serpentine group and the other five to the amphibole group of minerals. Chrysotile fibre bundles split easily and magnesium can be leached under weak acid conditions. These factors may contribute to the lower biopersistence of chrysotile in the lungs.

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“…Accurate exposure assessment is crucial in these cases. Risk estimates of lung cancer and mesothelioma associated with increased pulmonary concentrations of asbestos fibers, as well as reference fiber concentrations observed in the general population, based on results obtained with electron microscopy, have recently been published in Finland (2,3,4).…”

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confidence: 99%

Pulmonary asbestos bodies and asbestos fibers as indicators of exposure

Karjalainen¹,

Nurminen²,

Vanhala³

et al. 1996

Scand J Work Environ Health

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Objectives The aim of the study was to analyze the correlation between pulmonary conceutrations of asbestos bodies and asbestos fibers and to characterize asbestos body counts from lung tissue of Fiunish patients occupationally exposed and unexposed to asbestos.Methods Ninty-nine surgically treated lung cancer patients were investigated. The number of asbestos bodies in iron-stained 5-pm histological lung tissue sections was determined by optical microscopy, and the pulmonary concentration of asbestos fibers was assessed by scanning electron microscopy. The correlatioll between asbestos body and asbestos fiber counts was calculated with linear regression. The asbestos body and asbestos fiber concentrations were also compared with exposure history according to a personal interview of the patients. ResultsThe average number of asbestos bodies ranged from < 0.1 to 750 asbestos bodies per tissue section.All the cases with definite exposure showed an average of at least one asbestos body per tissue section. An average of at least one asbestos body per section was, however, detected in 34% of the patients with unlikely exposure. The regression equation log (AF) = -0.429 + 0.600 . log (AB) was found to predict the concentration of asbestos fibers (AF, 1O6fibers . g-') corresponding to a given number of asbestos bodies (AB) in a section of lung tissue. C O~~C~U S~O~SThe background level of asbestos bodies in the lungs of patients with no specific asbestos exposure seeins to be higher in Finland than in other countries. In medicolegal cases, the methodological variation involved in asbestos fiber and asbestos body counting must be recognized and all available exposure data should be used to produce the best possible estimate of the exposure.

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Relative risk of mesothelioma associated with different levels of exposure to asbestos.

Cited by 69 publications

References 16 publications

Mineral fiber content of lungs in patients with mesothelioma seeking compensation in Québec.

Mineral fiber content of lungs in patients with mesothelioma seeking compensation in Québec.

Guidelines for mineral fibre analyses in biological samples: report of the ERS Working Group. European Respiratory Society

Pulmonary asbestos bodies and asbestos fibers as indicators of exposure

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