Guidelines for mineral fibre analyses in biological samples: report of the ERS Working Group. European Respiratory Society

Vuyst, Paul De; Karjalainen, Antti; Dumortier, Pascal; Pairon, Jean‐Claude; Monsó, Eduard; Brochard, Patrick; Teschler, Helmut; Tossavainen, Antti; Gibbs, A R

doi:10.1183/09031936.98.11061416

Cited by 151 publications

(123 citation statements)

References 45 publications

(60 reference statements)

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“…Counting asbestos bodies (AB)s in bronchoalveolar lavage fluid (BALF) by light microscopy can be used to help evaluate an individual9s past exposure to asbestos [7]. ABs mainly reflect exposure to amphibole asbestos.…”

mentioning

confidence: 99%

Trends in asbestos body counts in bronchoalveolar lavage fluid over two decades

Dumortier¹,

Thimpont²,

Maertelaer³

et al. 2003

Eur Respir J

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Trends in asbestos body counts in bronchoalveolar lavage fluid over two decades. P. Dumortier, J. Thimpont, V. de Maertelaer, P. De Vuyst. #ERS Journals Ltd 2003. ABSTRACT: As in most western countries, the use of asbestos has decreased in Belgium since the mid 19709s. Successive regulations have lowered the permissible levels of exposure and prohibited the use of various asbestos products.In order to assess the impact of these prevention measures on the pulmonary fibre burden of asbestos-exposed patients, the bronchoalveolar lavage fluid (BALF) asbestos body (AB) analysis database of the authors9 laboratory was reviewed for the period 1983-2000.A total of 4,772 cases were considered, of which 95% were males. AB concentration exceeded 1 AB?mL BALF -1 in 36.1%. There was essentially no change in the mean concentration of AB over the period evaluated. However, the concentrations in individuals with very high levels decreased over time. This was associated with a shift in exposure categories from primary asbestos workers to those exposed during handling of asbestos-containing materials or to asbestos in place in buildings or industrial sites. This is consistent with epidemiological data indicating that the number of severe cases of asbestosis caused by very high cumulated doses decreases but that benign pleural diseases and mesothelioma remain the most frequent asbestos-related diseases. Past prevention measures are not expected to have a measurable influence on the incidence of mesothelioma in the near future.

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confidence: 99%

Trends in asbestos body counts in bronchoalveolar lavage fluid over two decades

Dumortier¹,

Thimpont²,

Maertelaer³

et al. 2003

Eur Respir J

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“…It intersects with the concept of mineralogical analyses of which the usefulness has been perfectly illustrated in the case of asbestosis where the assessment of asbestos bodies (AB) in patient lung tissues or in broncho-alveolar lavage (BAL) fluids has allowed defining threshold values specific of pathologies (1000 AB/g in bronchial cancer, 6000 AB/g in mesothelioma and more than 100000 AB/g in asbestos fibrosis against 67 AB/g in healthy control) (De Vuyst et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Metal load assessment in patient pulmonary lavages: towards a comprehensive mineralogical analysis including the nano-sized fraction

et al. 2017

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Mineralogical analyses of clinical samples have been proved useful to identify causal relationship between exposure to airborne particles and pulmonary diseases. The most striking example is asbestosis where the assessment of asbestos bodies in patient lung samples has allowed defining values specific of pathologies. However this type of analyses only considers the micro-sized fraction of the particles, neglecting the specific impact of nano-sized particles which have been otherwise shown to be reactive and able to induce biological effects.Similarly, in nanotoxicology, the mineralogical analysis of pulmonary fluids could be used as an indicator of exposure to inhaled nanoparticles and could help investigations on the relationship between exposure to these nanoparticles and lung diseases. We designed this study first to demonstrate the technical feasibility of this approach, then to get a clear picture of the metals present, and in what form, in patient lungs and finally to determine if indeed it is worth investigating separately the micro, sub-micro and nano fractions. Broncho-alveolar lavages were recovered from 100 patients suffering from interstitial lung diseases. A protocol was specifically developed to isolate 3 fractions containing respectively microparticles, submicroparticles and nanoparticles with ions. The metal content in each fraction was qualitatively and quantitatively characterized. Results showed significant differences between the 3 fractions in terms of metal load confirming that the separate analysis of the fractions is relevant. It also means that the assessment of the micro-sized fraction alone, as commonly done in clinical practice, only gives a partial view of the mineralogical analysis.

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“…It must be noted that the assessment of occupational exposure is based only on the occupation(s) reported by the patient; there was no consideration of duration and intensity of exposure. Moreover, chrysotile fibres were not taken into account in the interpretation of the results of BALF analysis because of the possibility of environmental exposures to chrysotile in some parts of Turkey and the fact that due to a lower biopersistence than that of amphiboles, the chrysotile fibre burden in lung samples is not a reliable marker of exposure [18]. Despite these limitations, an occupational exposure appears very unlikely in a Turkish immigrant when no industrial amphiboles are detected in his BALF (or lung tissue).…”

Section: Discussionmentioning

confidence: 99%

The role of environmental and occupational exposures in Turkish immigrants with fibre-related disease

Dumortier

Göçmen²,

Laurent³

et al. 2001

Eur Respir J

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Environmental exposure to tremolite and erionite causes endemic diseases of the lung and pleura in Turkey. This study aimed to evaluate the impact of these exposures and further occupational exposures on fibre-related diseases in Turkish immigrants living in Belgium.The study included 51 males and 17 females that emigrated <1–38 yrs ago. Most of them (n=46) had nonmalignant pleural lesions, one had asbestosis and one had mesothelioma. Environmental asbestos exposure was likely for the majority of patients (60%), but there were also reports of possible occupational asbestos (n=14) and erionite (n=2) exposure.Tremolite was the main fibre type in bronchoalveolar lavage fluid (BALF). Elevated concentrations of amosite or crocidolite were detected in only two patients. The delay elapsed since the end of the environmental exposure had no influence on the asbestos body or the tremolite fibre concentrations in the BALF of Turkish immigrants.Most fibre-related diseases in Turkish immigrants are probably due to environmental rather than occupational exposure. Precise information about geographical origin and occupation should be obtained when investigating these patients. Mineralogical analysis of bronchoalveolar lavage fluid gives valuable information on the type and intensity of exposure, especially in patients with both environmental and occupational exposure.

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Guidelines for mineral fibre analyses in biological samples: report of the ERS Working Group. European Respiratory Society

Cited by 151 publications

References 45 publications

Trends in asbestos body counts in bronchoalveolar lavage fluid over two decades

Trends in asbestos body counts in bronchoalveolar lavage fluid over two decades

Metal load assessment in patient pulmonary lavages: towards a comprehensive mineralogical analysis including the nano-sized fraction

The role of environmental and occupational exposures in Turkish immigrants with fibre-related disease

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