Relative risk of developing asthma after prenatal antibiotic exposure: Protocol for a systematic review and meta-analysis

Cait, Alissa; Wedel, Alexander; Arntz, Jeanne L.; Duinkerken, Jacyra; Datye, Swarali; Alhasan, Moumen M.; Conrad, Melanie L.

doi:10.17169/refubium-27428

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“…A pre-registered review protocol was deposited in the Freie Universität Berlin institutional repository (refubium) on July 1, 2020. 29 The protocol and this manuscript are both reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The protocol is registered in the International prospective register of systematic reviews (PROSPERO) ID: CRD42020191940.…”

Section: Reporting Protocol and Registrationmentioning

confidence: 99%

“…Detailed inclusion/exclusion criteria can be found in our published protocol. 29 Briefly, studies were included if (i) they were published in English, German, French, Dutch, or Arabic (ii) the intervention was the use of any antibiotic at any time point during pregnancy (iii) the study reported atopic disease incidence in the offspring with a primary outcome of asthma or wheeze. Study assessments of atopic sensitization, dermatitis/eczema, allergic rhinitis, and/or food allergy in association with wheeze or asthma development were also included.…”

Section: Eligibility Criteriamentioning

confidence: 99%

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Prenatal antibiotic exposure, asthma, and the atopic march: A systematic review and meta‐analysis

Cait

Wedel²,

Arntz

et al. 2022

Allergy

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Antibiotic use during pregnancy may increase the risk for asthma in children. We performed a meta-analysis assessing prenatal antibiotic exposure and the risk for childhood wheeze or asthma, as well as for diseases associated with the atopic march.A systematic literature search protocol (PROSPERO-ID: CRD42020191940) was registered and searches were completed using Medline, Proquest, Embase, and the Cochrane central register of controlled trials. Screening for inclusion criteria: published in English, German, French, Dutch, or Arabic, intervention (use of any antibiotic at any time point during pregnancy), and disease (reporting atopic disease incidence in children with a primary outcome of asthma or wheeze), and exclusion criteria: reviews, preclinical data, and descriptive studies, yielded 27 studies. Study quality was assessed using the Newcastle-Ottawa Assessment Scale. Quality of the evidence was assessed using the Grading of Recommendations Assessment, Development, 42

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Section: Reporting Protocol and Registrationmentioning

confidence: 99%

Section: Eligibility Criteriamentioning

confidence: 99%