Relative risk factors associated with the development of fundic gland polyps

Abstract

Age and the long-term use of PPIs were risk factors for the presence of FGPs; the long-term use of PPIs was a particularly strong risk factor.

A Clinico-Pathological Study of Gastric Polyps and Their Relationship with Helicobacter Pylori Infection atthe Pathology Departments of Hospitals in Yazd from 2011 To 2016

“…In the present study, hyperplastic polyps made up 69.3% of all the reported gastric polyps, which agrees with the results obtained by Markowski AR et al, who reported that, although most gastric polyps in the US are of the fundus type, 25% to 71% of the polyps found in their study were hyperplastic [9]. The incidence of hyperplastic polyps increases with age and they are mostly observed in people over 65 [1,4]. These findings are consistent with the present findings regarding the higher prevalence of polyps in the age group over 60 and the highest frequency of polyp type pertaining to hyperplastic polyps.…”

“…H. pylori infection was three times more prevalent in women than in men, although no significant relationships were observed between gender and the type of polyp. A review of literature shows that, hyperplastic polyps were the most common type of polyp concomitant with H. pylori infection [3,4,6] In line with other studies, most polyps had no concomitant pathologies in the present study. In a study conducted by Markowski AR et al on the clinical symptoms of polyps, most polyps were found to be asymptomatic and were detected incidentally, also in the present study, the most frequent clinical symptom reported was abdominal pain [9].…”

“…Helicobacter pylori (H. pylori) is the most common cause of bacterial infection in the world. Its prevalence is associated significantly with age and varies from 10% in people below age 30 to 60% in those over age 60 [4,5]. This infection is more prevalent in developing countries and affects more than 80% of the population by age 20.…”

“…The most common gastric polyp is hyperplastic polyp (75%), which is often benign and in multiple form and mainly develops under chronic inflammatory conditions and is less likely to become malignant [2,3]. Polyps may regress, remain constant or enlarge over time; however, these polyps often regress after the eradication of the H. pylori infection [2,4]. Men and women are equally affected and mainly in mid to late adulthood.…”

Presence of Fundic Gland Polyps in Patients Undergoing Upper Gastrointestinal Endoscopy: Incidence and the Relation with the Use of Proton Pump Inhibitors

“…Recently, it was noticed that Fundic Gland Polyps (FGP's) are more frequently seen. There are reports in the literature stating that this condition is associated with the long-term use of Proton Pump Inhibition (PPI) [2].…”