Presence of Fundic Gland Polyps in Patients Undergoing Upper Gastrointestinal Endoscopy: Incidence and the Relation with the Use of Proton Pump Inhibitors

Abstract

Introduction: It was noticed that Fundic Gland Polyps (FGP) are more frequently seen. There are reports suggesting that this condition is associated with the use of Proton Pump Inhibition (PPI).

Proton pump inhibitors are not associated with fundic gland polyps – a systematic review that takes into consideration all known confounders

“…Twenty-two studies [14][15][16][17][18][19][20][21][22][23][24][25]28,[30][31][32][33]35,36,50,90,91] reported FGPs in PPI-users (n = 5534) and PPI-nonusers (n = 41 115). They satisfied the inclusion criteria.…”

“…[ 20 ], Zelter et al . [ 21 ], Loffeld [ 23 ], Shinozaki et al . [ 94 ]; duration 20–40 months: Ally et al .…”

“…In the 22 studies searched (Table 1), the association of PPI with FGP remains controversial with 14 studies (total subjects, n = 11 661) for [14–25,91,96] and 8 (total subjects, n = 29 454) against [28,30–33,35,36,50,94].…”

“…The association between PPIs and fundic gland polyps (FGPs) has been controversial since it was first proposed in 1992 [14]; and there have been reports for [15][16][17][18][19][20][21][22][23][24][25] and against [26][27][28][29][30][31][32][33][34][35][36]. Two meta-analyses [37,38] in 2016 supported the association.…”