Relative molar response of a flame ionization detector to some organic compounds containing sulfur

Filby, W. G.; Guenther, K.G.; Penzhorn, R.-D.

doi:10.1021/ac60363a056

Cited by 3 publications

(1 citation statement)

References 22 publications

(13 reference statements)

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“…Capillary GC/MS (Gas chromatography-mass spectrometry) method 6 for the determination of EMS has been reported within the linear range of 50–200 μg/g. GC-FID (gas chromatography-flame ionization detector) method 7 have been reported for the determination of alkyl methanesulfonates but this method had the drawback of higher limit of detection. Moreover, GC-FID not being a very selective and specific technique.…”

Section: Introductionmentioning

confidence: 99%

Low Level Determinations of Methyl Methanesulfonate and Ethyl Methanesulfonate Impurities in Emtricitabine Active Pharmaceutical Ingredient by LC/MS/MS using Electrospray Ionization

Kakadiya¹,

Chandrashekhar²,

Ganguly³

et al. 2011

Anal Chem�Insights

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Alkyl methanesulfonates have been highlighted as potential genotoxic impurities (PGIs). A sensitive LC/MS/MS method was developed and validated for the determination of Alkyl methanesulfonate impurities in Emtricitabine API (active pharmaceutical ingredient). LC/MS/MS method on Zorbax SB C18 column (150 × 4.6 mm i.d.), 3.5 μm, with electrospray ionization (ESI) in multiple reaction monitoring (MRM) mode was used. The proposed method was specific, linear, accurate, rugged and precise. The calibration curves showed good linearity over the concentration range of 0.0025 μg/ml to 0.3 μg/ml the correlation coefficient was >0.999 in each case. Method had very low limit of detection (LOD) and limit of quantification (LOQ) as 0.3 μg/g and 0.4 μg/g respectively for both the analytes. Accuracy was observed within 80%–120% for both the analytes. This method can be further extended a good quality control tool for low level quantitation of Alkyl methanesulfonate impurities in other API.

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Section: Introductionmentioning

confidence: 99%