Relative importance of summer sun exposure, vitamin D intake, and genes to vitamin D status in Dutch older adults: The B-PROOF study

Brouwer‐Brolsma, Elske M.; Vaes, Anouk M.M.; Zwaluw, Nikita L. van der; Wijngaarden, J.P. van; Swart, Karin M. A.; Ham, Annelies C.; Dijk, Suzanne C. van; Enneman, Anke W.; Sohl, E.; Schoor, Natasja M. van; Velde, Nathalie van der; Uitterlinden, André G.; Lips, Paul; Feskens, Edith J. M.; Dhonukshe-Rutten, R.A.M.; Groot, Lisette C. P. G. M. de

doi:10.1016/j.jsbmb.2015.08.008

Cited by 93 publications

(75 citation statements)

References 46 publications

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“…Vitamin D 3 öncelikle deride sentezlenir ve karaciğerde hidroksillenerek 25 (OH) vitamin D'yi oluşturur (7)(8)(9)(10). 1,25 (OH) vitamin D, böbreklerde bir hidroksilasyon işlemi daha geçirerek aktif metabolik formuna dönüşür (7,8,11).…”

Section: Introductionunclassified

“…1,25 (OH) vitamin D, böbreklerde bir hidroksilasyon işlemi daha geçirerek aktif metabolik formuna dönüşür (7,8,11). Kalsitriol, steroit yapıda bir hormon olup D vitaminin aktif şekli olarak kalsiyum iyonunu destekler (7,8,11). Son yıllarda DVE; metabolik sendrom, kardiyovasküler hastalıklar, enfeksiyöz ve otoimmün hastalıklar hatta kanserlerin içinde bulunduğu birçok kronik hastalıklarla ilişkili bulunmuştur (2,3,(6)(7)(8)(11)(12)(13)(14)(15).…”

Section: Introductionunclassified

“…DVE, yaşamın tüm safhalarında karşılaşılabilen ve metabolizma üzerinde farklı etkileri olabilen klinik bir durumdur. En sık nedeni güneş ışığından yeterli yararlanamamaktır (3,4,6,7,11,14,15). D vitamini kalsiyum homeostazisini düzenleyerek sağlıklı kemik döngüsünü idame ettirmenin dışında; beyin, kas, pankreas, meme, prostat, gonadlar, kolon gibi dokularda yer alan reseptörleri sayesinde tüm metabolizmayı etkileyebilir.…”

Section: Introductionunclassified

“…D vitamini kalsiyum homeostazisini düzenleyerek sağlıklı kemik döngüsünü idame ettirmenin dışında; beyin, kas, pankreas, meme, prostat, gonadlar, kolon gibi dokularda yer alan reseptörleri sayesinde tüm metabolizmayı etkileyebilir. T lenfositler üzerindeki reseptörleri aracılığı ile anti-enflamatuvar, proapopitotik immün-modülatuvar özellikler gösterir (2,3,(6)(7)(8)(11)(12)(13)(14)(15). Erişkin popülasyonda DVE prevalansının yüksek olduğu bilinmektedir.…”

Section: Introductionunclassified

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ssessment of the Relationship Between Vitamin D Level and Non-specific Musculoskeletal System Pain: A Multicenter Retrospective Study (Stroke Study Group)

Karahan¹,

Hüner²,

Kuran³

et al. 2017

Tod

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Section: Introductionunclassified

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ssessment of the Relationship Between Vitamin D Level and Non-specific Musculoskeletal System Pain: A Multicenter Retrospective Study (Stroke Study Group)

Karahan¹,

Hüner²,

Kuran³

et al. 2017

Tod

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“…Studies found variation in circulating 25(OH)D levels by sex with women often demonstrating lower concentrations, though trends varied [27,56–58]. A recent study by Wanner et al observed a statistically significant interaction on the association between self-reported moderate-vigorous physical activity and circulating 25(OH)D levels in men versus women (p-interaction=0.003) [59].…”

Section: Discussionmentioning

confidence: 99%

Physical activity, sedentary behavior, and vitamin D metabolites

Hibler

Molmenti

Dai

et al. 2016

Bone

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Physical activity is associated with circulating 25-hydroxyvitamin D (25(OH)D). However, the influence of activity and/or sedentary behavior on the biologically active, seco-steroid hormone 1α,25-dihydroxyvitamin D (1,25(OH)2D) is unknown. We conducted a cross-sectional analysis among ursodeoxycholic acid (UDCA) randomized trial participants (n=876) to evaluate associations between physical activity, sedentary behavior, and circulating vitamin D metabolite concentrations. Continuous vitamin D metabolite measurements and clinical thresholds were evaluated using multiple linear and logistic regression models, mutually adjusted for either 1,25(OH)2D or 25(OH)D and additional confounding factors. A statistically significant linear association between 1,25(OH)2D and moderate-vigorous physical activity per week was strongest among women (β (95% CI): 3.10 (1.51–6.35)) versus men (β (95% CI): 1.35 (0.79–2.29)) in the highest tertile of activity compared to the lowest (p-interaction=0.003). Furthermore, 25(OH)D was 1.54 ng/ml (95% CI 1.09–1.98) higher per hour increase in moderate-vigorous activity (p=0.001) and odds of sufficient 25(OH)D status was higher among physically active participants (p=0.001). Sedentary behavior was not significantly associated with either metabolite in linear regression models, nor was a statistically significant interaction by sex identified. The current study identified novel associations between physical activity and serum 1,25(OH)2D levels, adjusted for 25(OH)D concentrations. These results identify the biologically active form of vitamin D as a potential physiologic mechanism related to observed population-level associations between moderate-vigorous physical activity with bone health and chronic disease risk. However, future longitudinal studies are needed to further evaluate the role of physical activity and vitamin D metabolites in chronic disease prevention.

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“Light” as an Environmental Factor for the Well‐Being of the “Plant, Animal, and Human Triad”

2023

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Relative importance of summer sun exposure, vitamin D intake, and genes to vitamin D status in Dutch older adults: The B-PROOF study

Cited by 93 publications

References 46 publications

ssessment of the Relationship Between Vitamin D Level and Non-specific Musculoskeletal System Pain: A Multicenter Retrospective Study (Stroke Study Group)

ssessment of the Relationship Between Vitamin D Level and Non-specific Musculoskeletal System Pain: A Multicenter Retrospective Study (Stroke Study Group)

Physical activity, sedentary behavior, and vitamin D metabolites

“Light” as an Environmental Factor for the Well‐Being of the “Plant, Animal, and Human Triad”

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