Relative Importance of Pancreatic, Hepatic, and Mucosal Bicarbonate in Duodenal Neutralization of Acid in Anaesthetized Pigs

Ainsworth, Mark; Svendsen, P.; Ladegaard, Lars; Cantor, Per; Olsen, Ole; Muckadell, Ove B. Schaffalitzky de

doi:10.3109/00365529209000085

Cited by 10 publications

(2 citation statements)

References 29 publications

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“…It is, however, difficult from the present study to assess the importance of biliary bicarbonate secretion when compared to pancreatic and mucosal bicarbonate output in conscious pigs. When hepatic, pancreatic and duodenal mucosal bicarbonate secretions were investigated simultanously in the anaesthetized pigs (Ainsworth et al . 1992) hepatic bicarbonate production was the most important contribution to neutralization.…”

Section: Discussionmentioning

confidence: 99%

Regulation of porcine biliary secretion by secretin

Sætre

Andersen

Houe

et al. 1998

Acta Physiologica Scandinavica

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The importance of physiological plasma levels of secretin in biliary bicarbonate secretion is not known. However, in anaesthetized pigs the substantial hepatic output of bicarbonate into the duodenum in response to low doses of secretin exceeds pancreatic bicarbonate output. The aim was therefore to study the relationship between duodenal acidification, secretin and hepatic biliary bicarbonate output in the conscious pig. Göttingen minipigs (n = 22) were cholecystectomized and the common bile duct catheterized. The biliary bicarbonate secretion in response to intraduodenal HCl, secretin or pentagastrin given intravenously, and to meal was studied. Intraduodenal HCl infusion, secretin and pentagastrin given intravenously augmented hepatic bicarbonate output and plasma secretin concentrations significantly. The secretin response to acidification was sufficient to explain the subsequent increase in biliary bicarbonate secretion. Hepatic bicarbonate secretion and concentrations of CCK and secretin in plasma increased postprandially. Exclusion of bile salts from the duodenum abolished postprandial increase in bile volume and increased release of CCK in fasting and fed pigs whereas secretin release was diminished. The results demonstrate that hepatic bicarbonate secretion is stimulated by endogenous secretin and therefore may have a physiological role in duodenal neutralization.

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Section: Discussionmentioning

confidence: 99%

Regulation of porcine biliary secretion by secretin

Sætre

Andersen

Houe

et al. 1998

Acta Physiologica Scandinavica

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“…Bile, and to minor extent pancreatic secretion, contains additional bicarbonate, needed to neutralize the acidic chime to a value between 5 and 6 in the duodenum. 66 Pancreatic secretion contains the proteases trypsin and chymotrypsin together with a cocktail of enzymes such as esterase, lipase, phospholipase and amylase. Most of these enzymes, including trypsin itself, are secreted as inactive proenzymes, which are activated by tryptic hydrolysis.…”

Section: Stomach Emptyingmentioning

confidence: 99%

Relating Food Emulsion Structure and Composition to the Way It Is Processed in the Gastrointestinal Tract and Physiological Responses: What Are the Opportunities?

Aken

2010

Food Biophysics

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The gastrointestinal tract is a complex and intricate machinery to process and absorb nutrients from food in a highly controlled and efficient way. One of the main purposes is to provide essential nutrients (proteins, fats, and carbohydrates) to the blood in a soluble form that can be further processed by the body. For this reason, the food is digested by various enzymes and brought into a state in which it can be absorbed by the small intestines. The proliferation of obesity in the Western world has motivated several research groups to study the digestion process, ultimately to control food intake by food design. This paper reviews the literature related to the digestion of food emulsions, describing in detail the organization and function of the various organs of the gastrointestinal tract, the way these organs cooperate and how this cooperation is regulated by physiological signals. The insight may help to cross the bridge toward designed food structuring from a food-engineering and physical-chemical perspective. Based on the physiological understanding of fat digestion, opportunities to affect the digestion of triglycerides by food structure and composition, stability under stomach conditions, and delayed digestion and absorption in the small intestine are identified.

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Fundamentals of Bicarbonate Secretion in Epithelia

Novak

Prætorius

2015

Ion Channels and Transporters of Epithelia in Health and Disease

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Relative Importance of Pancreatic, Hepatic, and Mucosal Bicarbonate in Duodenal Neutralization of Acid in Anaesthetized Pigs

Cited by 10 publications

References 29 publications

Regulation of porcine biliary secretion by secretin

Regulation of porcine biliary secretion by secretin

Relating Food Emulsion Structure and Composition to the Way It Is Processed in the Gastrointestinal Tract and Physiological Responses: What Are the Opportunities?

Fundamentals of Bicarbonate Secretion in Epithelia

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