Regulation of porcine biliary secretion by secretin

Sætre, S. S.; Andersen, Nicholas J.; Houe, T.; Svendsen, P.; Jf, Rehfeld; Olsen, Ole; Muckadell, Ove B Schaffalitzky de

doi:10.1046/j.1365-201x.1998.00349.x

Cited by 4 publications

(4 citation statements)

References 15 publications

(12 reference statements)

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“…Secretin is the principal hormonal stimulant driving bicarbonate and fluid secretion into the small intestine ( 42 , 54 , 55 ) . Secretin acts through attachment to G-protein-coupled receptors that also show affinity for vasoactive intestinal peptide ( 56 ) .…”

Section: Effect Of Ph On Pancreatic Lipase Activitymentioning

confidence: 99%

“…Similar studies on pancreatic juice suggest a stimulated volume output of 200 ml/h (52) with bicarbonate output reaching 90 mmol/l (53) (total stimulated output of , 20 mmol/h). Secretin is the principal hormonal stimulant driving bicarbonate and fluid secretion into the small intestine (42,54,55) . Secretin acts through attachment to G-protein-coupled receptors that also show affinity for vasoactive intestinal peptide (56) .…”

Section: Control Of Small-intestinal Phmentioning

confidence: 99%

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Physiological parameters governing the action of pancreatic lipase

et al. 2010

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The most widely used pharmacological therapies for obesity and weight management are based on inhibition of gastrointestinal lipases, resulting in a reduced energy yield of ingested foods by reducing dietary lipid absorption. Colipase-dependent pancreatic lipase is believed to be the major gastrointestinal enzyme involved in catalysis of lipid ester bonds. There is scant literature on the action of pancreatic lipase under the range of physiological conditions that occur within the human small intestine, and the literature that does exist is often contradictory. Due to the importance of pancreatic lipase activity to nutrition and weight management, the present review aims to assess the current body of knowledge with regards to the physiology behind the action of this unique gastrointestinal enzyme system. Existing data would suggest that pancreatic lipase activity is affected by intestinal pH, the presence of colipase and bile salts, but not by the physiological range of Ca ion concentration (as is commonly assumed). The control of secretion of pancreatic lipase and its associated factors appears to be driven by gastrointestinal luminal content, particularly the presence of acid or digested proteins and fats in the duodenal lumen. Secretion of colipase, bile acids and pancreatic lipase is driven by cholecystokinin and secretin release.

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Section: Effect Of Ph On Pancreatic Lipase Activitymentioning

confidence: 99%

Section: Control Of Small-intestinal Phmentioning

confidence: 99%

Physiological parameters governing the action of pancreatic lipase

et al. 2010

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“…The reason why ID oleate infusion did not increase first 90-minute pancreatic flow volume and bicarbonate output in the TBD dogs remains unclear, however we can speculate on the reason from the point of view of secretin and CCK. Secretin is released by duodenal acidification and bile exclusion diminishes secretin release in conscious pig (Saetre et al 1998). Basal pancreatic bicarbonate secretion was strongly enhanced in the TBD dogs which would suppress duodenal acidification, resulting in inhibition of secretin release.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Bile Diversion Enhances Basal and Duodenal Oleate-Stimulated Pancreatic Exocrine Secretion in Dogs

Takahashi

Naitö

Sasaki

et al. 2004

Tohoku J. Exp. Med.

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There have been no previous reports whether long-term bile diversion enhances pancreatic exocrine secretion. The aim of this study was to elucidate the effect of longterm bile diversion on pancreatic exocrine secretion. Four mongrel dogs were prepared for chronic gastric and pancreatic fistulas and received intraduodenal sodium oleate infusion (controls). These dogs, then underwent diversion of bile from the intestines by ligating the common bile duct and interposing a segment of jejunum between the gallbladder and the urinary bladder (total biliary diversion [TBD]). After three weeks, the dogs received an identical sodium oleate infusion. TBD augmented basal pancreatic exocrine secretion compared with controls (4.4-fold increase in basal flow volume; 9.0-fold increase in bicarbonate output; and 3.3-fold increase in protein output). Likewise, TBD augmented oleate-stimulated exocrine secretion (2.0-fold increase in cumulative flow volume; 2.6-fold increase in bicarbonate output; and 1.4-fold increase in protein output). TBD also augmented basal and oleate-stimulated plasma cholecystokinin levels. Administration of a Cholecystokinin-A receptor antagonist (loxiglumide) after TBD reduced the flow volume and bicarbonate output to the control levels, and the protein output to less than a half of the control level. Long-term bile diversion enhances basal and oleate-stimulated pancreatic exocrine secretion, at least partly via increased cholecystokinin secretion. biliary diversion; chronic pancreatic fistula; pancreatic exocrine secretion; cholecystokinin; loxiglumide

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“…This makes it unlikely that VIP released from VIPergic nerve fibres is involved in the regulation of biliary bicarbonate secretion. Secretin is the regulatory peptide of greatest importance for the humoral control of biliary bicarbonate secretion [36]. As expected, high-affinity specific secretin-binding sites have been identified on rat bile duct epithelium [37].…”

Section: Discussionmentioning

confidence: 99%

Effect of Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide on Pancreatic, Hepatic and Duodenal Mucosal Bicarbonate Secretion in the Pig

Glad

Ainsworth²,

Svendsen³

et al. 2003

Digestion

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Background and Method: The potency of pituitary adenylate cyclase-activating polypeptide (PACAP) and the related vasoactive intestinal peptide (VIP) on pancreaticobiliary and duodenal mucosal bicarbonate secretion (DMBS) was studied in anaesthetized pigs. VIP, PACAP27 and PACAP38 were infused at doses of 250, 500, 1,000, 2,000 and 6,000 pmol/kg·h. Results: Infusion of VIP in these concentrations increased the portal plasma concentrations of VIP from 9 to 102, 220, 600, 850 and 3,795 pM, respectively. At doses of 1,000 and 6,000 pmol/kg·h all three peptides significantly stimulated pancreatic bicarbonate secretion, VIP from 0.0 to 0.3 and 7.6 mmol/h, PACAP27 from 0.0 to 2.3 and 8.2 mmol/h, and PACAP38 from 0.0 to 0.2 and 7.4 mmol/h, respectively. Only during infusion of 6,000 pmol/kg·h did the three peptides elicit a significant increase in hepatic bicarbonate output. At this dose VIP increased hepatic bicarbonate output from 0.4 to 3.8 mmol/h, PACAP27 from 0.3 to 3.6 mmol/h, and PACAP38 from 0.1 to 1.4 mmol/h, respectively. Infusion of VIP (500, 1,000, 2,000 and 6,000 pmol/kg·h) dose-dependently and significantly enlarged DMBS from 0.09 to 0.19, 0.41, 0.54 and 0.53 mmol/h, respectively. A significant effect of PACAP27 and PACAP38 on DMBS was only obtained at a dose of 6,000 pmol/kg·h, and at this dose VIP-induced DMBS was 4- and 8-fold higher than that induced by PACAP27 and PACAP38, respectively. Conclusions: VIP, PACAP27 and PACAP38 all have a pharmacological effect on both DMBS and pancreaticobiliary bicarbonate secretion. When comparing these results with the distribution of VIP/PACAP neurons and relevant receptors, it seems likely that VIP and PACAP have a physiological importance as neurotransmitters in the pancreas and duodenum, but not in the liver. The differences in the effect of VIP and PACAP on DMBS observed in this study indicate that there are variations between pancreatic and duodenal PACAP/VIP receptor subtypes, or that the duodenal inactivation of the peptides is different from the inactivation in the pancreas.

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Regulation of porcine biliary secretion by secretin

Cited by 4 publications

References 15 publications

Physiological parameters governing the action of pancreatic lipase

Physiological parameters governing the action of pancreatic lipase

Long-Term Bile Diversion Enhances Basal and Duodenal Oleate-Stimulated Pancreatic Exocrine Secretion in Dogs

Effect of Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide on Pancreatic, Hepatic and Duodenal Mucosal Bicarbonate Secretion in the Pig

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