Relative frequency of Haemophilus influenzae type b pneumonia in Chinese children as evidenced by serology

Abstract

As in most other series from other countries, the leading agent causing childhood pneumonia was pneumococcus but, in line with our previous experience from Beijing, the second most common agent detected was Hib. This observation suggests great potential for pneumococcal and Hib vaccinations in China. Because no evidence supported the need for routine use of extended spectrum antimicrobials, narrower spectrum agents would be safer for patients, would be cheaper for the community and would offer a way to address increasing resistance problems.

A multiplex PCR‐based reverse line blot hybridization (mPCR/RLB) assay for detection of bacterial respiratory pathogens in children with pneumonia

“…In China, the only previous studies of pneumonia, which included modern serologic tests for both bacterial and viral etiologies, are our series of hospitalized children with acute lower respiratory infections in 1997 and 1998. 6,25 The main bacterial agents identified in that particular series were S. pneumoniae and H. influenzae as in the present study. A more accurate measure of the burden of vaccine-preventable pneumonia could be obtained by a prospective, descriptive study or by a disease burden study, undertaken in conjunction with the introduction of pneumococcal and Hib conjugate vaccines in children.…”

Etiology of Community-acquired Pneumonia in Hospitalized Children in Northern Taiwan

“…3,4,21,22 The observation in this study should not be biased given that a positive test for IgM and seroconversion to IgG is generally considered adequate for the diagnosis of Mycoplasma pneumoniae infection. The incidence of mycoplasmal infection appeared to be lower in other areas of the world and the reported rate was only around 7-14%.…”

Widespread of non‐typeable Haemophilus influenzae with high genetic diversity after two decades use of Hib vaccine in China

“…The β-lactamase-positive rate and the antimicrobial resistance pattern of the 190 isolates tested were similar to our previous report. 3 BLNAR isolates were previously considered rare in China (0%-1.3%). 32,33 However, in the current study, 36 isolates of BLNAR were identified from 190 test isolates (18.9%).…”

“…2 It is also the second most common bacterial pathogen causing pneumonia in Chinese children. 3,4 In the past several decades, its resistance of H influenzae has increased in many countries, but there is a significant difference between geographic sites and monitoring time. 5 A previous study in Beijing showed that the percentage of β-lactamase positive was 4% in 2000, 13% in 2002, 27% in 2010, and 31% in 2012, and few β-lactamase-negative ampicillin-resistant (BLNAR) isolates were detected.…”