Relative frequencies of symptoms and risk factors among patients with chronic rhinosinusitis with nasal polyps using a case-control study

Bohman, Anton; Oscarsson, Martin; Holmberg, K.; Johansson, Leif; Millqvist, Eva; Nasic, Salmir; Bende, Mats

doi:10.1080/00016489.2017.1366052

Cited by 12 publications

(13 citation statements)

References 16 publications

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“…The incidence (but not the gender proportion) of smokers (32.6%) follows that of the Portuguese population 41 . In a manner similar to our patients, other studies have also reported a higher prevalence of smokers in sinusitis groups 42 , as well as a lower proportion of NP patients who smoke, both in national and international cohorts 40,43,44 . Although Lund-Mackay scores aren't used in clinical decision, they represent the extent of sinus inflammation (even though the score may be different from 0 in any given healthy individual).…”

Section: Discussionsupporting

confidence: 91%

The potential role of peak nasal inspiratory flow to evaluate active sinonasal inflammation and disease severity

Araújo-Martins

Brás-Geraldes

Neuparth

2020

Sci Rep

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Although the pathophysiology of nasal polyposis is incompletely understood, rhinologists have seldom studied it with rhinomanometry or peak nasal inspiratory flow (PNIF) due to technical limitations and the perception that polyp size might impair reproducibility and the usefulness of recordings. The objective of this study is to assess how measures of rhinomanometry and PNIF relate to disease activity. Nineteen patients with polyps, 15 patients with chronic sinusitis without polyps and 11 negative controls were evaluated with active anterior rhinomanometry and PNIF. Sinusitis and polyp patients were re-evaluated after medical treatment. Polyp patients had the highest median Lund-Mackay score (14) and a median Johansen score of 1. PNIF and its variation after treatment were also lowest in this group (median 90 L/min before and after treatment; median variation of 0 L/min). Nasal resistance was similar between groups, and only correlated with Johansen score (Spearman = 0.517, p = 0.048) after treatment. Our study suggests that evaluating polyp patients using rhinomanometry and PNIF may provide useful and reproducible data. Several findings considered together suggest that polyp size is not the main determinant of nasal functional changes in these patients, warranting further studies to verify whether PNIF changes reflect sinus inflammation or merely airway obstruction.

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Section: Discussionsupporting

confidence: 91%

The potential role of peak nasal inspiratory flow to evaluate active sinonasal inflammation and disease severity

Araújo-Martins

Brás-Geraldes

Neuparth

2020

Sci Rep

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“…[16][17][18] Recent studies have also identified the importance of nasal congestion or obstruction, nasal drip, and loss of smell in patients with CRS with nasal polyps. 23,24 Building on the identification of symptoms as relevant to the population with nasal polyps, participants in the current study discussed their symptoms in terms of frequency, duration, and severity, providing an in-depth understanding of the symptomatology, the specific characteristics of which were not detailed within the current published literature. [16][17][18] Relationships identified between different nasal polyps symptoms during the concept elicitation interviews demonstrated the complexity of the patient experience in this condition, with links between the primary symptom of nasal congestion and symptoms occurring as a consequence of the primary symptoms (eg, difficulty breathing through the nose, cough, loss of smell, and loss of taste).…”

Section: Discussionmentioning

confidence: 99%

Understanding the Patient Experience of Severe, Recurrent, Bilateral Nasal Polyps: A Qualitative Interview Study in the United States and Germany

et al. 2020

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Objectives: To qualitatively explore patient experiences of severe, recurrent, bilateral nasal polyps (NP). Methods: A targeted literature review of published qualitative studies and online blogs describing patient experiences of NP was conducted. Semistructured concept elicitation interviews were conducted in the United States and Germany with participants $18 years with severe, recurrent, bilateral NP to explore their symptom experience and impacts on health-related quality of life (HRQoL; NCT03221192). A subset of 10 participants reported symptoms and impacts using a smartphone or tablet application (app) over a 10-day period. Results: A paucity of qualitative evidence regarding patient experience of NP was identified from the literature or blog review. Twenty-seven participant interviews were conducted. Thirty-six symptoms were identified, including 7 primary symptoms (nasal congestion [n = 27 of 27], breathing difficulties [n = 27 of 27], postnasal drip [n = 25 of 27], runny nose [n = 24 of 27], head/facial pressure [n = 23 of 27], loss of smell [n = 23 of 27], loss of taste [n = 22 of 27]) and 29 secondary symptoms (the most common were mucus/catarrh and nose bleeds [both n = 20 of 27]). Most symptoms were reported to vary both within and between days. Sixty impacts of severe NP were reported, including impacts on sleep (n = 22 of 27), physical functioning (n = 21 of 27), activities of daily living (n = 21 of 27), emotional well-being (n = 27 of 27), treatment (n = 23 of 27), social life (n = 26 of 27), and work (n = 19 of 27). Symptoms/impacts reported using the app were consistent with interview findings, although new symptoms were identified (ear pain, throat pain, nasal scabs, and nasal burning). These results supported the development of a conceptual model outlining concepts related to symptoms, impacts, and treatment of NP. Conclusions: Severe, recurrent, bilateral NP are associated with a range of symptoms that have significant detrimental impact on HRQoL.

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“…Nasal congestion was reported in 95-100% of patients with CRSwNP in North America 17,27 , 73-88% of patients in Europe 34,35 , and 76-81% of patients in Asia 31,36 . Loss of smell was reported for 56-84% of patients with CRSwNP in North America 16,27 , 35-90% of patients in Europe 28,34,35,37,38 , and 30-100% of patients in Asia [30][31][32]36,39 . Sneezing was reported for 88% of patients in North America 26 , 12-73% of patients in Europe 28,34,35,38 , and 27-51% of patients in Asia 31,33 .…”

Section: Symptomsmentioning

confidence: 99%

“…Loss of smell was reported for 56-84% of patients with CRSwNP in North America 16,27 , 35-90% of patients in Europe 28,34,35,37,38 , and 30-100% of patients in Asia [30][31][32]36,39 . Sneezing was reported for 88% of patients in North America 26 , 12-73% of patients in Europe 28,34,35,38 , and 27-51% of patients in Asia 31,33 . Headache was reported for 33-95.8% of patients in North America 27,40 , 20-41% of patients in Europe 33,34 , and 2-76% of patients in Asia 33,36 .…”

Section: Symptomsmentioning

confidence: 99%

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Systematic literature review of the epidemiology and clinical burden of chronic rhinosinusitis with nasal polyposis

Chen

Zhou

Emmanuel

et al. 2020

Current Medical Research and Opinion

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Objectives: We conducted a systematic literature review (SLR) to determine the epidemiology and clinical burden of chronic rhinosinusitis with nasal polyps (CRSwNP) and to describe how the addition of biologics has affected outcomes for patients with CRSwNP. Methods: The SLR adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Embase, MEDLINE, and Evidence-Based Medicine Reviews databases were searched using OVID. Relevant studies published between 1

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Relative frequencies of symptoms and risk factors among patients with chronic rhinosinusitis with nasal polyps using a case-control study

Abstract: By comparing symptoms and risk factors of patients with CRSwNP with those of a large population-based control group and testing them in a multiple logistic regression model, we have been able to generate data that address key research interests in CRSwNP.

Cited by 12 publications

References 16 publications

The potential role of peak nasal inspiratory flow to evaluate active sinonasal inflammation and disease severity

The potential role of peak nasal inspiratory flow to evaluate active sinonasal inflammation and disease severity

Understanding the Patient Experience of Severe, Recurrent, Bilateral Nasal Polyps: A Qualitative Interview Study in the United States and Germany

Systematic literature review of the epidemiology and clinical burden of chronic rhinosinusitis with nasal polyposis

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