Relative Frequencies of Alzheimer Disease, Lewy Body, Vascular and Frontotemporal Dementia, and Hippocampal Sclerosis in the State of Florida Brain Bank

Barker, Warren W.; Luis, Cheryl A.; Kashuba, Alice; Luis, Mercy; Harwood, Dylan G.; Loewenstein, David; Waters, Carol; Jimison, Pat; Shepherd, Eugene; Sevush, Steven; Graff-Radford, Neil; Newland, Douglas; Todd, Mark E.; Miller, B. Lynn; Gold, Michael; Heilman, Kenneth M.; Doty, Leilani; Goodman, Ira; Robinson, Bruce; Pearl, Gary S.; Dickson, Dennis W.; Duara, Ranjan

doi:10.1097/00002093-200210000-00001

Cited by 591 publications

(428 citation statements)

References 59 publications

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“…How well our results may generalize to the aged population at large is unknown, but in this context the heterogeneity of this sample is strength. Community-based studies using autopsy confirmation of diagnosis have generally shown a substantial frequency of cases with "mixed dementia," with reported rates ranging from 40% to 77% (Barker et al, 2002;White et al, 2005). Some degree of caution about the generalizability of the results does seem warranted given differences between the study and parent samples.…”

Section: Discussionmentioning

confidence: 95%

Cognitive and neuroimaging predictors of instrumental activities of daily living

Cahn-Weiner

Farias

Julián

et al. 2007

J. Inter. Neuropsych. Soc.

184

167

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Impaired ability to conduct daily activities is a diagnostic criterion for dementia and a determinant of healthcare services utilization and caregiver burden. What predicts decline in instrumental activities of daily living (IADLs) is not well understood. This study examined measures of episodic memory, executive function, and MRI brain volumes in relation to baseline IADLs and as predictors of rate of IADL change. Participants were 124 elderly persons with cognitive function between normal and moderate dementia both with and without significant small vessel cerebrovascular disease. Random effects modeling showed that baseline memory and executive function (EXEC) were associated with baseline IADL scores, but only EXEC was independently associated with rate of change in IADLs. Whereas hippocampal and cortical gray matter volumes were significantly associated with baseline IADL scores, only hippocampal volume was associated with IADL change. In a model including cognitive and neuroimaging predictors, only EXEC independently predicted rate of decline in IADL scores. These findings indicate that greater executive dysfunction at initial assessment is associated with more rapid decline in IADLs. Perhaps executive function is particularly important with respect to maintaining IADLs. Alternatively, executive dysfunction may be a sentinel event indicating widespread cortical involvement and poor prognosis.

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Section: Discussionmentioning

confidence: 95%

Cognitive and neuroimaging predictors of instrumental activities of daily living

Cahn-Weiner

Farias

Julián

et al. 2007

J. Inter. Neuropsych. Soc.

184

167

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“…In a pathological study of 382 brains of individuals with dementia who were referred to the State of Florida Brain Bank, the vast majority (77%) had a pathological diagnosis of AD (Barker et al 2002). Of these, 54% had "pure" AD pathology, whereas concomitant pathologies (e.g., Lewy body or vascular disease) were detected in the remainder.…”

Section: Differential Diagnosismentioning

confidence: 99%

“…Of these, 54% had "pure" AD pathology, whereas concomitant pathologies (e.g., Lewy body or vascular disease) were detected in the remainder. Additionally, AD pathology was present in most cases of dementia with Lewy bodies (DLB) (66%) and vascular dementia (77%) (Barker et al 2002).…”

Section: Differential Diagnosismentioning

confidence: 99%

“…It is estimated that less than 5% of dementia cases in the United States are caused by stroke alone (Barker et al 2002). It is important, however, to recognize contributions of vascular pathology to dementia in AD; cerebrovascular lesions can precipitate the appearance of dementia in AD, or contribute to the cognitive impairment in the early stages.…”

Section: Vascular Dementiamentioning

confidence: 99%

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The Clinical Problem of Symptomatic Alzheimer Disease and Mild Cognitive Impairment

Tarawneh

Holtzman

2012

Cold Spring Harbor Perspectives in Medicine

325

218

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Alzheimer disease (AD) is the most common cause of dementia in the elderly. Clinicopathological studies support the presence of a long preclinical phase of the disease, with the initial deposition of AD pathology estimated to begin approximately 10-15 years prior to the onset of clinical symptoms. The hallmark clinical phenotype of AD is a gradual and progressive decline in two or more cognitive domains, most commonly involving episodic memory and executive functions, that is sufficient to cause social or occupational impairment. Current diagnostic criteria can accurately identify AD in the majority of cases. As disease-modifying therapies are being developed, there is growing interest in the identification of individuals in the earliest symptomatic, as well as presymptomatic, stages of disease, because it is in this population that such therapies may have the greatest chance of success. The use of informant-based methods to establish cognitive and functional decline of an individual from previously attained levels of performance best allows for the identification of individuals in the very mildest stages of cognitive impairment.

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“…Many diseases can cause dementia, but Alzheimer's disease (AD) is the most common [2,3]. Vascular dementia and dementia with Lewy bodies (DLB) are the next most common [2,3] whilst frontotemporal lobar degeneration (FTLD) is the third most common dementing disease under 65 years [4].…”

Section: Introductionmentioning

confidence: 99%

Does registration of serial MRI improve diagnosis of dementia?

et al. 2010

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Introduction We aimed to assess the value of a second MR scan in the radiological diagnosis of dementia. Methods One hundred twenty subjects with clinical followup of at least 1 year with two scans were selected from a cognitive disorders clinic. Scans were reviewed as a single first scan (method A), two unregistered scans presented sideby-side (method B) and a registered pair (method C). Scans were presented to two neuroradiologists and a clinician together with approximate scan interval (if applicable) and age. Raters decided on a main and subtype diagnosis. Results There was no evidence that differences between methods (expressed as relative odds of a correct response) differed between reviewers (p = 0.17 for degenerative condition or not, p=0.5 for main diagnosis, p=0.16 for subtype). Accordingly, results were pooled over reviewers.For distinguishing normal/non-progressors from degenerative conditions, the proportions correctly diagnosed were higher with methods B and C than with A (p=0.001, both tests). The difference between method B and C was not statistically significant (p=0.18). For main diagnosis, the proportion of correct diagnoses were highest with method C for all three reviewers; however, this was not statistically significant comparing with method A (p=0.23) or with method B (p=0.16). For subtype diagnosis, there was some evidence that method C was better than method A (p=0.01) and B (p=0.048).Conclusions Serial MRI and registration may improve visual diagnosis in dementia.

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Relative Frequencies of Alzheimer Disease, Lewy Body, Vascular and Frontotemporal Dementia, and Hippocampal Sclerosis in the State of Florida Brain Bank

Cited by 591 publications

References 59 publications

Cognitive and neuroimaging predictors of instrumental activities of daily living

Cognitive and neuroimaging predictors of instrumental activities of daily living

The Clinical Problem of Symptomatic Alzheimer Disease and Mild Cognitive Impairment

Does registration of serial MRI improve diagnosis of dementia?

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