Relative efficacy of intracameral moxifloxacin injection methods

Abstract

When injecting prophylactic intracameral moxifloxacin, the method of 0.5 to 0.6 mL × 150 μg/0.1 mL yields closest to the desired 500 μg retained in the AC, when considering mixing during injection.

Reply: Relative efficacy of intracameral moxifloxacin injection methods

“…Our recommended injection method yields a curve that flattens out with increased volumes of injection, making achieving a dangerous concentration unlikely, barring dilution errors in preparation, whereas small volume full-strength injection, especially if placed under the iris in a phakic eye, may achieve a trapped toxic concentration. 1 As commented by Khachikian and Jones, we agree that heightened caution is warranted when injecting undiluted IC moxifloxacin into phakic eyes.…”

“…We would like to thank Khachikian and Jones for their interest in our recent article and for their compliments on our previous publications. 1 They expressed concern primarily on potential intracameral (IC) moxifloxacin toxicity in phakic eyes.…”

“…When diluted moxifloxacin is injected, the AC concentration gradually approaches the concentration of the injected solution, which is the asymptotic limit with increasing injection volume. 1…”

Comment on: Relative efficacy of intracameral moxifloxacin injection methods

“…We read with great interest the article by Arshinoff and Shi evaluating the efficacy of moxifloxacin preparation and injection methods. 1 Dr. Arshinoff has made significant contributions in the use of intracameral antibiotics to reduce the incidence of postoperative endophthalmitis, and the efforts to standardize administration are commendable. Drs.…”