Relative Distribution of Plutonium and Americium Following Experimental PuO2 Implants

Johnson, L.J.; Watters, Robert L.; Lagerquist, C.R.; Hammond, S.E.

doi:10.1097/00004032-197012000-00004

Cited by 14 publications

(5 citation statements)

References 6 publications

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“…These findings are consistent with the known importance of the superficial cervical lymph nodes in the translocation of plutonium from the front paws of beagles (JOHNSON et al, 1970;BISTLINE et al, 1972;BISTLINE, 1973;GOMEZ et al. 1972;GOMEZ, 1973), and the tracheobronchial lymph nodes in the translocation of plutonium from the lungs of beagles (BAIR, 1970;CLARKE et al, 1964;PARK et al, 1962).…”

Section: Discussionsupporting

confidence: 80%

“…REGIONAL lymph nodes are major repositories for plutonium in beagles after subcutaneous injections simulating contamination of hand wounds (JOHNSON et al, 1970;WATTERS and LEBEL, 1971;LEBEL and WATTERS, 1972;BISTLINE et al, 1972;BISTLINE, 1973). Plutonium continued to accumulate for 2-4 weeks in the left superficial cervical lymph nodes of dogs after implantation of plutonium into the left forepaw.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Translocation Kinetics of Plutonium Oxide from the Popliteal Lymph Nodes of Beagles

Dagle¹,

Lebel²,

Phemister³

et al. 1975

Health Physics

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The translocation kinetics of high-fired plutonium oxide from the popliteal lymph nodes was studied in beagles with 9.2 to 39.445 of plutonium-239 oxide implanted subcutaneously in the left hind paws to simulate accidental contamination of hand wounds. The left hind paw was amputated 4 weeks after implantation to prevent continued deposition of plutonium oxide particles in the left popliteal lymph node. External in situ scintillation data showed slight clearance of plutonium from the popliteal lymph nodes of beagles monitored for 32 weeks. The estimated time for the fraction of plutonium retained at 100 days to be reduced by one-half varied from 290 to 1508 days. Treatment with DTPA did not have a measurable effect on the clearance of high-fired plutonium oxide from popliteal lymph nodes.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Translocation Kinetics of Plutonium Oxide from the Popliteal Lymph Nodes of Beagles

Dagle¹,

Lebel²,

Phemister³

et al. 1975

Health Physics

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show abstract

“…Similarly, different excretion rates following chelation therapy show that Am excretion does not necessarily reflect the removal rate of the Pu. (12) Despite this, it is often necessary to utilize the convenient 241Am X-ray for early evaluation of a suspected Pu exposure especially if the Am/Pu ratio of the material is available.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Removal of Internally Deposited Transuranium Elements

Vh¹

1972

Health Physics

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Treatment for the accidental incorporation of the transuranic elements is mainly dependent on chelation therapy. Most of the therapeutic experience has evolved, justifiably, for the removal of plutonium. The plutonium therapeutic regimens may serve as a rough guide to the treatment of other transuranides, although, quantitatively, dissimilarities based on chemical and incorporated mass differences are to be expected. With the added complication of the biological disposition of the daughter products and the high specific activities of some of the isotopes, any significant incorporation should be treated, and treated promptly.While progress in the treatment of plutonium has been slow, a better understanding of removal from specific tissues, such as liver, bone and lung, for soluble and insoluble plutonium materials, is being achieved. The brightest spot is the ability to remove about half the inhaled particulates, plutonium or other transuranics, from the lung by lung washing. Coupled with the judicious use of chelation therapy this should significantly reduce the hazard from inhaled transuranics.These and other aspects of the treatment for poisoning by the transuranic elements will be discussed.

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“…However, faster in vivo dissolution of U than Th was suggested from inhalation studies with pitchblende (STUART and BEASLEY, 1967) or carnotite (STUART and JONES, 1968). These and other similar data (JOHNSON et al, 1970;THOMAS, 1971;and Moss, 1976) suggest that, when the particle matrix is relatively soluble, the dissolution rates of the individual components could be substantially different from each other. The intrinsic solubility of the major components will be one of the most important factors affecting the dissolution, and, therefore, clearance from the lung and translocation to other tissues or excretion, of mixed matrix aerosols.…”

Section: Treatment Of Components Of Inhaled Mixturesmentioning

confidence: 63%

Implications of the Dosimetric Model for the Respiratory System on Limits for Intakes of Radionuclides by Workers (Icrp Publication 30)

Craig

Brain

Cuddihy

et al. 1982

The Annals of Occupational Hygiene

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Abstract-While evaluating respiratory tract kinetic models, we have encountered a number of problems with the recently published ICRP Dosimetric Model for the Respiratory System. Some of those to be discussed are the following.1. The assumption that the nasopharyngeal (N-P) region can be ignored, despite considerable evidence of significant retention in the N-P region and of pathological effects.2. Treatment of the tracheobronchial tree (T-B), the pulmonary (P) region and the pulmonary lymph nodes (PLN) as one combined organ for calculating dose.3. The lack of deposition estimates for very small particles ( <0.1 /im dia.) and the use of a probit scale for percentage deposition.4. Use of the aerodynamic equivalent diameter of particles beyond the range of applicability of the model and the desirability of defining an appropriate 'equivalent deposition diameter' suitable for the whole range of particle sizes of interest.5. Treatment of components of inhaled mixtures as if they are independent in regard to both deposition and clearance characteristics.6. Limitations of the currently used rigid solubility classifications (D, W or Y) of inorganic compounds in estimating retention and disposition of deposited particles.

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Relative Distribution of Plutonium and Americium Following Experimental PuO2 Implants

Cited by 14 publications

References 6 publications

Translocation Kinetics of Plutonium Oxide from the Popliteal Lymph Nodes of Beagles

Translocation Kinetics of Plutonium Oxide from the Popliteal Lymph Nodes of Beagles

Therapeutic Removal of Internally Deposited Transuranium Elements

Implications of the Dosimetric Model for the Respiratory System on Limits for Intakes of Radionuclides by Workers (Icrp Publication 30)

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