Translocation Kinetics of Plutonium Oxide from the Popliteal Lymph Nodes of Beagles

Dagle, G.E.; Lebel, J.L.; Phemister, Robert D.; Watters, Robert L.; Gomez, Leo S.

doi:10.1097/00004032-197504000-00010

Cited by 4 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the metal appears to concentrate there and is only very slowly released. Similar results have been reported for plutonium and americium using a dog model (Bistline et al 1972;Dagle et al 1985). One could hypothesize that macrophages at the implantation site ingest and concentrate the strontium in the phagolysosomal vesicles, travel to the lymph nodes, and either remain there or die leaving the strontium in the tissue.…”

Section: Discussionsupporting

confidence: 82%

See 1 more Smart Citation

Biokinetics of Embedded Surrogate Radiological Dispersal Device Material

Emond

Kalinich

2012

Health Physics

View full text Add to dashboard Cite

The terrorist use of a radiological dispersal device (RDD) has been described as "not if, but when" (). Exposures from such an event could occur by a number of routes including inhalation, wound contamination, or embedded fragments. Several of the radionuclides thought to be potential RDD components are metals or ceramic material. The use of such material would increase the potential for wounds from embedded fragments of radioactive material. To date, most research in this area has focused on inhalation exposures, while the consequence of embedded fragment exposure has not been investigated. This study modified a previously used rodent model in order to determine the biokinetics of intramuscularly implanted nonradioactive surrogate RDD material. Cobalt, iridium, or strontium titanate was embedded into the gastrocnemius muscle of Sprague Dawley rats. The rats were euthanized at 1, 3, or 6 mo post-implantation. Tissue metal analysis showed that iridium did not solubilize from the implanted pellet, while cobalt and strontium did so rapidly. Cobalt was found in all tissues analyzed, but it was localized mainly to kidney and liver as well as being excreted in the urine. Strontium was found in lung, liver, and spleen, as well as being deposited in bone. However, the greatest strontium concentrations were found in the popliteal lymph nodes, the lymph nodes responsible for draining the area of the gastrocnemius. These results indicate that, depending upon the material, a variety of treatment strategies will be needed when dealing with embedded fragment wounds from a radiological dispersal device event.

show abstract

Section: Discussionsupporting

confidence: 82%

“…Mixtures categorized as insoluble are often found to have both soluble and insoluble characteristics when assessed in an in vivo model system (Bistline et al 1972;Dagle et al 1985). This also appears to be the case in this study.…”

Section: Discussionsupporting

confidence: 72%

Biokinetics of Embedded Surrogate Radiological Dispersal Device Material

Emond

Kalinich

2012

Health Physics

View full text Add to dashboard Cite

show abstract

Heavy Metal-Induced Carcinogenicity: Depleted Uranium and Heavy-Metal Tungsten Alloy

Kalinich¹

2011

Cellular Effects of Heavy Metals

View full text Add to dashboard Cite

Experimental Studies of the Translocation of Plutonium from Simulated Wound Sites in the Rat

Harrison¹,

David²,

Stather³

1978

International Journal of Radiation Biology and Related Studies

View full text Add to dashboard Cite

Wound contamination with plutonium was simulated in rats by injection into either muscle or subcutaneous tissue. The distribution after the injection of plutonium nitrate indicated that: (i) clearance from the contaminated tissue was due mainly to the movement of soluble complexes of plutonium, principally to the skeleton and liver, but also involved slower movement of polymerized, particulate plutonium to lymph nodes; (ii) clearance of soluble plutonium, and hence the overall state of clearance, was dependent on the tissue fluid flow through the contiminated tissue and the mass of plutonium deposited; (iii) lymphatic clearance of particulate plutonium resulted in the release of some particles into the circulation and subsequent uptake by the liver. Intramuscular deposition of small plutonium dioxide particles (approximately 1 nm in diameter) resulted in a greater rate of clearance of plutonium than deposition of the nitrate. Although the solubility of these particles was evident from the level of skeletal uptake of plutonium, a high level of excretion indicated that some plutonium was filtered into the urine in an undissolved form.

show abstract

Translocation Kinetics of Plutonium Oxide from the Popliteal Lymph Nodes of Beagles

Cited by 4 publications

References 7 publications

Biokinetics of Embedded Surrogate Radiological Dispersal Device Material

Biokinetics of Embedded Surrogate Radiological Dispersal Device Material

Heavy Metal-Induced Carcinogenicity: Depleted Uranium and Heavy-Metal Tungsten Alloy

Experimental Studies of the Translocation of Plutonium from Simulated Wound Sites in the Rat

Contact Info

Product

Resources

About