Relative contributions of diet and sunlight to vitamin D state in the elderly.

Lawson, David; Paul, Alison; Black, A.; Cole, TJ; Mandal, Anandadeep; Davie, M. W. J.

doi:10.1136/bmj.2.6185.303

Cited by 159 publications

(56 citation statements)

References 15 publications

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“…The conclusion that vitamin D intakes have a much greater effect on vitamin D status in the winter than the summer was previously documented for older people living in the United Kingdom (Lawson et al, 1979). The present study suggests that this is probably common to all age groups.…”

Section: Discussionsupporting

confidence: 79%

Vitamin D: seasonal and regional differences in preschool children in Great Britain

et al. 1999

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Results: Vitamin D status is highly dependent on season: moreover, the relation between vitamin D intake and status is also seasonally dependent, being strong in the winter and negligible in the summer. During the winter, those children who had relatively low 25OH-D concentrations generally were those not receiving vitamin D supplements. Vitamin D intakes and supplement use were lower in the north than in the south of Britain. Conclusions: For British preschool children, dietary vitamin D is of much greater importance in the winter than in the summer. There is evidence of regional inequality, with lesser use of supplements in the north. Supplements are needed in the winter, to achieve satisfactory vitamin D status and minimise the risk of rickets and of poor bone health, especially in high-risk groups.

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Section: Discussionsupporting

confidence: 79%

Vitamin D: seasonal and regional differences in preschool children in Great Britain

et al. 1999

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“…Furthermore, it is possible that genetic variants may mediate prostate cancer risk via a mechanism involving availability of 1,25(OH) 2 D (e.g., certain variants may only be relevant in men with vitamin D deficiency, a common condition with aging; refs. 34,35). We tested for interaction with intake of vitamin D; however, we only had information on dietary vitamin D and vitamin D from multivitamins and had no information on individual vitamin D supplements and, importantly, sun exposure (UV-B radiation), the major source of (40).…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Association Analysis of the Vitamin D Pathway Genes, VDR, CYP27B1, and CYP24A1, in Prostate Cancer

Holick

Stanford

Kwon

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Genetic variation in vitamin D -related genes has not been investigated comprehensively and findings are equivocal. We studied the association between polymorphisms across the entire vitamin D receptor (VDR) gene and genes encoding for vitamin D activating enzyme 1-A-hydroxylase (CYP27B1) and deactivating enzyme 24-hyroxylase (CYP24A1) and prostate cancer risk among middle-aged men using a population-based case-control study design. DNA samples and survey data were obtained from incident cases (n = 630), 40 to 64 years old, identified through the Seattle-Puget Sound Surveillance, Epidemiology, and End Results cancer registry from 1993 to 1996 and from random controls (n = 565) of similar age without a history of prostate cancer. We selected and genotyped tag single-nucleotide polymorphisms to predict common variants across VDR (n = 22), CYP27B1 (n = 2), and CYP24A1 (n = 14). Haplotypes of VDR and CYP24A1 were not associated with prostate cancer risk. In the genotype analysis, homozygotes at two VDR loci (rs2107301 and rs2238135) were associated with a 2-to 2.5-fold higher risk of prostate cancer compared with the homozygote common allele [odds ratio, 2.47 (95% confidence interval, 1.52-4.00; P = 0.002) and 1.95 (95% confidence interval, 1.17-3.26; P = 0.007), respectively; P value corrected for multiple comparisons for VDR = 0.002]. We found no evidence that the two associated VDR single-nucleotide polymorphisms were modified by age at diagnosis, prostate cancer aggressiveness, first-degree family history of prostate cancer, or vitamin D intake. Genotypes of CYP27B1 and CYP24A1 were not associated with prostate cancer risk. Our findings suggest that polymorphisms in the VDR gene may be associated with prostate cancer risk and, therefore, that the vitamin D pathway might have an etiologic role in the development of prostate cancer. (Cancer Epidemiol Biomarkers Prev 2007;16(10):1990 -9)

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“…The NIH RDA for vitamin D is 200 IUaday, but recent studies suggested that, especially in the elderly, higher amounts ( b 400 ± 500 IUaday) are needed (Dawson-Hughes et al, 1995). In youngsters and adults, skin cell synthesis is considered suf®cient to produce 400 IU of vitamin D every day as long as the exposure to sunlight is adequate (Lawson, 1979). However, skin cell synthesis of vitamin D in the elderly is more likely to be insuf®cient, since they tend to spend less time outdoors and the ability of their skin to synthesize vitamin D 3 is reduced (Holick et al, 1989).…”

Section: Reducing Lipid Level Improves Calcium Intake a Gaddi Et Almentioning

confidence: 99%

The realization of a project aimed at reducing the plasmatic lipid level in a large Italian population improves the mean calcium daily intake: the Brisighella Study

et al. 2001

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Objectives: Evaluation of the impact of a coronary heart disease prevention program on calcium, magnesium, phosphorus and vitamin D dietary intake in respect of recommended daily allowances in a large Italian rural population. Design: Retrospective analysis of the Brisighella Study dietary data. The Brisighella Study started in 1972 as a longitudinal study on atherosclerosis risk factors. Setting: Brisighella, a rural North Italian village. Subjects: The Brisighella population's dietary habits were monitored from 1980 every 4 h through a dietary record sheet. 1350 constantly tested subjects were subdivided according to NHI Consensus Conference on Calcium RDA. Intervention: In 1986, the studied subjects were invited to reduce their consumption of animal fats and cholesterol through a Nutrition Educational Program (NEP). Results: Before NEP, calcium intake was low in each sex and age category: 20 ± 40% of the populatioin had a daily intake`550 mg. In 1988, among the 1350 subjects who constantly completed the questionnaire (M 651, F 699), the mean calcium intake signi®cantly rose in all age categories: M 1003 (25 ± 65 y) and 877 ( b 65) mga24 h (P`0.001 vs 1984); F 923 (25 ± 50), 860 (51 ± 65) and 767 ( b 65) mga24 h (P`0.05). In 1992, 3 y after the NEP conclusion, calcium intake dropped in each sex and age category. The NEP in¯uenced vitamin D, phosphorus and magnesium intakes less. Conclusions: A collective NEP aimed at lowering saturated fats and cholesterol intakes, improves the calcium intake; in order to maintain their ef®cacy on nutritional habit changes, these programs must become an ongoing item.

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Relative contributions of diet and sunlight to vitamin D state in the elderly.

Cited by 159 publications

References 15 publications

Vitamin D: seasonal and regional differences in preschool children in Great Britain

Vitamin D: seasonal and regional differences in preschool children in Great Britain

Comprehensive Association Analysis of the Vitamin D Pathway Genes, VDR, CYP27B1, and CYP24A1, in Prostate Cancer

The realization of a project aimed at reducing the plasmatic lipid level in a large Italian population improves the mean calcium daily intake: the Brisighella Study

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