Relationships of Hyperhomocysteinemia and Hyperuricemia With Metabolic Syndrome and Renal Function in Chinese Centenarians

Abstract

As the first time worldwide, this study aimed to investigate the relationships of hyperhomocysteinemia and hyperuricemia with metabolic syndrome (MetS) and renal function in Chinese centenarians. The China Hainan Centenarian Cohort Study was performed in 18 cities and counties of the Hainan Province. Home interview, physical examination, and blood analysis were performed on 808 centenarians following standard procedures. All centenarians had a median age of 102 (100–115) years. Prevalence of hyperhomocysteinemia and hyperuricemia was 91.6% (740 centenarians) and 28.5% (230 centenarians), respectively. The MetS was present in 117 centenarians (14.5%). In simple correlation analyses, hyperhomocysteinemia and hyperuricemia were significantly correlated with MetS and glomerular filtration rate (GFR) < 60 ml/min/1.73 m2 (P < 0.05 for all). Serum homocysteine levels were significantly correlated with GFR, waist circumference (WC), and triglyceride levels, while serum uric acid levels were significantly correlated with these variables plus high-density lipoprotein cholesterol (HDL-C) levels (P < 0.05 for all). In logistic regression analyses, hyperhomocysteinemia and hyperuricemia were significantly associated with MetS and GFR < 60 ml/min/1.73 m2 (P < 0.05 for all). In linear regression analyses, serum homocysteine levels were significantly associated with GFR, WC, and triglyceride, while serum uric acid levels were significantly associated with these variables plus HDL-C (P < 0.05 for all). Both hyperhomocysteinemia and hyperuricemia had important relationships with MetS and renal function in Chinese centenarians. Hyperuricemia and hyperhomocysteinemia that could help identify, while also affecting, the development of MetS and renal function may unfold complex relationships between MetS, renal function, and cardiovascular risk and provide effective prevention strategies for these conditions.

<p>Risk Factors For Hyperuricemia In Chinese Centenarians And Near-Centenarians</p>

“…3 Though hyperuricemia in the normal population does not cause clinically obvious symptoms, it is generally considered a precursor of gout and a potential pathogenic factor in metabolic syndrome, hypertension, diabetes, cardiovascular diseases and stroke. 4,5 Therefore, it is important to identify patients who are at high risk of hyperuricemia in a timely manner and treat them, preventing subsequent related diseases and the consequential increased financial burden. Further analysis showed that the prevalence of hyperuricemia gradually increased with increasing age.…”

Association between neck circumference and the risk of decreased estimated glomerular filtration rate in the general population of China: a cross-sectional study

“…Similar to the nding of the study performed by Chang-Yun Yoon et al, the association was more prominent among male subjects than among female subjects. Notably, previous studies failed to adjust serum uric acid, a well-established confounding factor between obesity and CKD (9,23,24). Compared with the above studies, the number of participants in our study was much larger, thereby allowing careful control of a wide spectrum of potential confounding factors, including serum uric acid, increasing the validity of our results.…”

Mechanisms Linking Hyperuricemia to Increased Cardiovascular Risk

“…Park et al4 observed a significant correlation of serum homocysteine levels with carotid intima-media thickness or renal impairments among hyperuricemic patients. The finding is not surprising based on the previous report that both metabolic syndrome and renal impairments are associated with homocysteinemia 5. Based on their results, the authors proposed a hypothesis where hyperuricemia induces homocysteinemia through renal impairments, which ultimately leads to atherosclerosis 4.…”