Relationships of 25-hydroxyvitamin D levels and non-alcoholic fatty liver disease in obese children: A possible strategy to promote early screening of NAFLD

Manoppo, Jeanette Irene Christiene; Pateda, Vivekenanda; Prayogo, Cindy; Langi, Fima L. F. G.; Mayulu, Nelly; Tsopmo, Apollinaire

doi:10.3389/fnut.2022.1025396

Cited by 2 publications

(6 citation statements)

References 46 publications

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“…There are large differences in the prevalence of NAFLD in children, as reported by recent studies compared to those of 5-10 years ago [7,9], and this primarily indicates a permanent increase over the years. These discrepancies may be due to the heterogeneity of the criteria used, as well as the mixed groups of children and adolescents [14].…”

Section: Discussionmentioning

confidence: 84%

“…On the contrary, other studies have not identified relationships between vitamin D insufficiency/deficiency and the histopathological aspects of NAFLD, nor with most components of MS, obesity or BMI [21]. Some authors consider that vitamin D has an anti-inflammatory rather than an anti-obesity effect [62], and others consider that the deficit is an independent factor for NAFLD [9]. In addition, in the first meta-analysis that investigated the link between vitamin D deficiency and NAFLD in children, the authors found an association that was not preserved when analyzing subgroups based on age, region and BMI [61], while other authors failed to demonstrate a direct relation of vitamin D with NAFLD [9].…”

Section: Discussionmentioning

confidence: 99%

“…Some authors consider that vitamin D has an anti-inflammatory rather than an anti-obesity effect [62], and others consider that the deficit is an independent factor for NAFLD [9]. In addition, in the first meta-analysis that investigated the link between vitamin D deficiency and NAFLD in children, the authors found an association that was not preserved when analyzing subgroups based on age, region and BMI [61], while other authors failed to demonstrate a direct relation of vitamin D with NAFLD [9]. These features once again underline the heterogeneity of the results.…”

Section: Discussionmentioning

confidence: 99%

“…In the same context, there are studies that tested the effects of vitamin D supplementation in adults or children, the results being controversial, in the context of the heterogeneity of the groups and the treatment [13,23]. While some authors recorded beneficial effects with a decrease in BP, weight and BMI; an increase in glucose tolerance; a decrease in insulin resistance; and an improvement in LDL, HDL and TG [28,63] and recommended additional vitamin D administration [8,49] even with a preventive purpose [9], others found no improvements in BMI [63], liver markers [64] or liver histology [60].…”

Section: Discussionmentioning

confidence: 99%

“…Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in pediatric pathology, in the absence of infections, medication or autoimmune processes [1][2][3]. The incidence of the disease is 3-17% in the pediatric population but can increase up to 80% in obese children [3][4][5][6][7][8][9], depending on the diagnostic methods [10,11] and the homogeneity of the studied groups [2,3].…”

Section: Introductionmentioning

confidence: 99%

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The Role of Vitamin D in Obese Children with Non-Alcoholic Fatty Liver Disease and Associated Metabolic Syndrome

et al. 2023

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Non-alcoholic fatty liver disease (NAFLD) represents a complex chronic condition, which in the absence of screening–monitoring markers and effective standardized treatment is one of the most important issues in pediatric pathology. In this study, we analyzed the role of vitamin D supplementation in obese children with/without NAFLD and the impact on the components of the associated metabolic syndrome (MS). The study included 22 children with simple obesity (SO) and 50 with NAFLD, aged between 6 and 14 years, who received regimen-based therapy or vitamin D supplementation in case of deficiency. Anthropometric and paraclinical data associated with MS were statistically compared before and after treatment. It was observed that there was a statistical association of NAFLD with MS components, which were present both in SO and in the 6–9 years group. Vitamin D deficiency was associated with the presence of obesity, NAFLD and MS components, and correction of the deficiency induced a tendency to normalize the associated parameters. In the case of a treatment strictly based on the regimen, we found decreases in vitamin D values and additional alteration of some parameters. Supplementation with vitamin D potentiates the effects of the specific regimen, and the effects seem to be dependent on the MS components.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Role of Vitamin D in Obese Children with Non-Alcoholic Fatty Liver Disease and Associated Metabolic Syndrome

et al. 2023

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Coagulation Dysfunctions in Non-Alcoholic Fatty Liver Disease—Oxidative Stress and Inflammation Relevance

Robea,

Balmus,

Girleanu

et al. 2023

Medicina

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Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases. Its incidence is progressively rising and it is possibly becoming a worldwide epidemic. NAFLD encompasses a spectrum of diseases accounting for the chronic accumulation of fat within the hepatocytes due to various causes, excluding excessive alcohol consumption. In this study, we aimed to focus on finding evidence regarding the implications of oxidative stress and inflammatory processes that form the multifaceted pathophysiological tableau in relation to thrombotic events that co-occur in NAFLD and associated chronic liver diseases. Recent evidence on the pathophysiology of NAFLD suggests that a complex pattern of multidirectional components, such as prooxidative, proinflammatory, and prothrombotic components, better explains the multiple factors that promote the mechanisms underlying the fatty acid excess and subsequent processes. As there is extensive evidence on the multi-component nature of NAFLD pathophysiology, further studies could address the complex interactions that underlie the development and progression of the disease. Therefore, this study aimed to describe possible pathophysiological mechanisms connecting the molecular impairments with the various clinical manifestations, focusing especially on the interactions among oxidative stress, inflammation, and coagulation dysfunctions. Thus, we described the possible bidirectional modulation among coagulation homeostasis, oxidative stress, and inflammation that occurs in the various stages of NAFLD.

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Relationships of 25-hydroxyvitamin D levels and non-alcoholic fatty liver disease in obese children: A possible strategy to promote early screening of NAFLD

Abstract: F and Tsopmo A ( ) Relationships of -hydroxyvitamin D levels and non-alcoholic fatty liver disease in obese children: A possible strategy to promote early screening of NAFLD.

Cited by 2 publications

References 46 publications

The Role of Vitamin D in Obese Children with Non-Alcoholic Fatty Liver Disease and Associated Metabolic Syndrome

The Role of Vitamin D in Obese Children with Non-Alcoholic Fatty Liver Disease and Associated Metabolic Syndrome

Coagulation Dysfunctions in Non-Alcoholic Fatty Liver Disease—Oxidative Stress and Inflammation Relevance

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