Relationships between Vitamin B6-vitamer Content and the Activities of Two Transaminase Enzymes in Rat Tissues at Varying Intake Levels of Vitamin B6

Studies on Certain Hepatic Enzymes and Protein Biosynthesis in Pyridoxine Deficient Rats

“…The reduced activity of this enzyme as well as the observed decrease in activity of that succinate dehydrogenase might have been due to the observed derangement in protein biosynthesis caused by pyridoxine deficiency (18). The decrease in AlT activity in pyrido xine deficiency is in accordance with some of the earlier findings (8)(9)(10)(11)(12)(13)(14)(15).…”

“…A number of investigators (8)(9)(10)(11)(12)(13)(14)(15) have reported that the pyridoxine deficiency depresses transaminase activity in various species, since pyridoxal phos phate acts as a coenzyme in the transaminase system. Role of pyridoxine in protein biosyn thesis has been already reported by Orekhovich (16) and Trakatellis et al (17).…”

Effect of feeding various dietary vitamin B6concentrations during gestation and lactation on vitamin B6level in liver and carcass of rat dams

“…This might be due to the fact that in a deficiency of vitamin B 6 the vitamin was first released from other tissues like muscle before liver (Kirksey et al, 1975;Brin and Thiele, 1967). This means that feeding a vitamin B 6 -deficient diet during gestation did not cause a total exhaustion of hepatic vitamin B 6 storage if rats were fed 3 or 6 mg/kg dietary vitamin B 6 during lactation.…”

“…In a study of Benedikt et al (1996b) it has been shown that only a vitamin B 6 supply of 3600 mg/kg during lactation changes the proportion of vitamin B 6 vitamers in maternal rat tissues. On the other hand increasing amounts of dietary pyridoxal immediately led to an alteration in the pyridoxol/pyridoxal-ratio (Brin and Thiele, 1967).…”

Effect of Pyridoxine on the Growth of Morris Hepatoma No. 7288Ctc and Enzyme Activity

“…It is also accepted that pyridoxal phosphate is the coenzyme of many classes of enzymes f 1 ]. Recent studies in this laboratory have shown that absence of pyridoxine from the diet inhibits significantly the growth of Morris hepatomas and alters the specific activity level of certain enzymes [2][3][4][5][6], Further, hormonal enzyme induction in animals with or without tumors is adversely affected by cofactor depletion [7][8][9], Other in vestigators have also reported alterations of enzyme activity levels in the absence of dietary pyridoxine [10][11][12], The ef fects of dietary pyridoxine on the growth of the poorly dif ferentiated Morris hepatoma no. 7288Ctc and the activity of tyrosine aminotransferase (TAT), a pyridoxal phosphaterequiring enzyme, were examined in this study.…”