Relationships between Minute Ventilation, Oxygen Uptake, and Time during Incremental Exercise

Abstract

It has recently been reported that blood and muscle lactate increased exponentially during incremental exercise, casting some doubt upon the concept of ‘anaerobic threshold’. To gain further insight into this controversy, we examined the relationships between minute ventilation (V_E), time and oxygen uptake (VO₂) in normal subjects during incremental exercise. During exercise, the relationship of V_E to either time of exercise or to VO₂ appeared curvilinear; V_E was reliably described as an exponential function (y = ax^b + c) of both time of exercise (r² = 0.96) and VO₂ (r² = 0.92). We also compared variables from 30-second incremental tests with variables obtained from quasi-steady-state incremental tests using cycle and treadmill ergometry. With the exception of heart rate, variables measured at maximum exercise were similar during short-duration and quasi-steady-state incremental tests. These data support the ideas that: (1) there is no abrupt change in metabolism and oxygen availability during progressive exercise, and (2) results of rapid incremental and quasi-steady-state exercise tests are generally comparable in normal individuals.

Workplace Breathing Rates: Defining Anticipated Values and Ranges for Respirator Certification Testing

“…Independently, Fairshter et al (39) also found an exponential relationship between VE and P02. However, the data presented by these investigators did not provide an exponential function for their entire test subject population.…”

Determinants of ventilatory inefficiency in transthyretin cardiac amyloidosis: The role of excessive ventilatory drive

“…In our patients, excessive ventilatory response to exercise was supported by increased ventilatory equivalent ratio for O 2 (V E / VO 2 ) and CO 2 (V E /VCO 2 ), low P ET CO 2 levels and excess ventilation at the anaerobic threshold (V E @AT VO2 ). Excess V E @AT VO2 is a reliable marker of elevated ventilatory drive, which is not affected by transient hyperventilation early in exercise and by metabolic acidosis during high levels of exercise (Jones and Campbell, 1982;Fairshter et al, 1987;Péronnet et al, 2007;Péronnet and Aguilaniu, 2014). According to Jones and Campbell equation (Jones and Campbell, 1982), expected ventilation during exercise from baseline to anaerobic threshold may be calculated as a linear function of oxygen uptake (VO 2 ).…”

“…Ventilatory reserve was calculated as ((MVV-peakV E )/MVV*100), where MVV is maximal voluntary ventilation calculated as FEV 1 multiplied by 35. Predicted V E at anaerobic threshold (AT) was calculated as V E @AT = 21.8*VO 2 + 5 (Jones and Campbell, 1982;Fairshter et al, 1987;Péronnet et al, 2007;Péronnet and Aguilaniu, 2014) and excess ventilation at anaerobic threshold (excess V E @AT VO2 ) was expressed as percent increase of predicted V E . Ventilatory efficiency, as indicated by V E relative to VCO 2 (V E -VCO 2 slope) rise was calculated off-line as a linear regression function using 10-s averaged values.…”

Evaluation of a New Treadmill Exercise Protocol

“…Hence, larger workloads and longer exercise durations are tolerated and higher values of peak HR and peak Vo 2 are achieved on the treadmill, 1,20,22,23,[35][36][37][38] apparently forming the basis of an enhanced sensitivity of the treadmill with respect to detection of ischemic heart disease. Hence, larger workloads and longer exercise durations are tolerated and higher values of peak HR and peak Vo 2 are achieved on the treadmill, 1,20,22,23,[35][36][37][38] apparently forming the basis of an enhanced sensitivity of the treadmill with respect to detection of ischemic heart disease.…”