Relationships between lifestyle factors and neutrophil functions in the elderly

Tsukamoto, Kazumasa; Machida, Kazuhiko; Saiki, Chinatsu; Murayama, Rumiko; Sugita, Minoru

doi:10.1002/jcla.10152

Cited by 15 publications

(14 citation statements)

References 22 publications

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“…Since we previously reported that low serum total protein is associated with low neutrophil phagocytic activity in the elderly [14], we measured serum total protein and albumin levels. Obesity and related metabolic disorders affect immune functions.…”

Section: Discussionmentioning

confidence: 99%

Effects of life events and stress on neutrophil functions in elderly men

Tsukamoto

Machida

2012

Immun Ageing

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Background Psychological stress or life events might significantly decrease neutrophil function in elderly individuals and lead to infectious diseases. However, relationships between these factors have not been examined in detail. We investigated the relationships between neutrophil function measured using the nitroblue tetrazolium (NBT) reduction test and measurements of psychological stress and life events among 81 men aged over 60 years. Results The numbers and scores for life events were significantly higher (p < 0.01, respectively) in a group with values reflecting phagocytosis below the median than in a control group. Conclusions Chronic psychological stress due to life events decreases neutrophil functions among elderly men.

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Section: Discussionmentioning

confidence: 99%

Effects of life events and stress on neutrophil functions in elderly men

Tsukamoto

Machida

2012

Immun Ageing

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“…As phagocytic granulocytes, they play an important role in consuming (through phagocytosis) and/or destroying (through granule release) extracellular pathogens. Regarding these two functions, immunosenescence appears to enhance phagocytic capacity (Tsukamoto et al 2002), but its effects on neutrophil cytokine and granule release are less clear, as researchers have reported conflicting findings based on the stimulus employed and lifestyle factors (Miyaji et al 2000; Plackett et al 2004). …”

Section: Immunosenescencementioning

confidence: 99%

Immunological outcomes of exercise in older adults

Senchina¹,

Kohut²

2007

Clinical Interventions in Aging

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Aging is associated with a dysregulation of the immune system known as immunosenescence. Immunosenescence involves cellular and molecular alterations that impact both innate and adaptive immunity, leading to increased incidences of infectious disease morbidity and mortality as well as heightened rates of other immune disorders such as autoimmunity, cancer, and inflammatory conditions. While current data suggests physical activity may be an effective and logistically easy strategy for counteracting immunosenescence, it is currently underutilized in clinical settings. Long-term, moderate physical activity interventions in geriatric populations appear to be associated with several benefits including reduction in infectious disease risk, increased rates of vaccine efficacy, and improvements in both physical and psychosocial aspects of daily living. Exercise may also represent a viable therapy in patients for whom pharmacological treatment is unavailable, ineffective, or inappropriate. The effects of exercise impact multiple aspects of immune response including T cell phenotype and proliferation, antibody response to vaccination, and cytokine production. However, an underlying mechanism by which exercise affects numerous cell types and responses remains to be identified. Given this evidence, an increase in the use of physical activity programs by the healthcare community may result in improved health of geriatric populations.

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“…Secondly, the technique avoids centrifugation, a process known to affect cell reactivity, and also avoids 'plating out' cells on glass slides -as used in the NBT test [26]. The cells are stimulated in vitro with PMA and the superoxide producing capacity of the cells is measured in real time.…”

Section: Introductionmentioning

confidence: 99%

Leukocyte reactivity as an objective means of quantifying mental loading during ergonomic evaluation

Shelton-Rayner

Macdonald

Chandler

et al. 2010

Cellular Immunology

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Psychological stress evokes rapid changes to the cardiovascular and neuroendocrine systems, responses that can become habituated following repeated exposure. This study, comprising of 2 phases, suggests that the immune system follows a similar trend. Phase 1: 15 healthy subjects (aged between 26 and 56 years) provided capillary blood samples before and after completing 3 basic tasks using, in turn, two automotive touch screen interfaces (Interface 1 -antecedent version, Interface 2 -improved version). Using a chemiluminescent technique termed Leukocyte Coping Capacity (LCC), the ability of leukocytes to produce reactive oxygen species in vitro was assessed. Significant differences in leukocyte activity were shown between treatment groups, where the greatest post-test decrease occurred after using Interface 1. Phase 2: a randomly selected sub-group (n=4) underwent weekly repeat testing using both interfaces. Significant differences in post-test leukocyte reactivity were exhibited between test weeks for each interface -the magnitude of response decreasing with successive exposure.

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Relationships between lifestyle factors and neutrophil functions in the elderly

Cited by 15 publications

References 22 publications

Effects of life events and stress on neutrophil functions in elderly men

Effects of life events and stress on neutrophil functions in elderly men

Immunological outcomes of exercise in older adults

Leukocyte reactivity as an objective means of quantifying mental loading during ergonomic evaluation

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