Effects of life events and stress on neutrophil functions in elderly men

Tsukamoto, Kazumasa; Machida, Kazuhiko

doi:10.1186/1742-4933-9-13

Cited by 14 publications

(12 citation statements)

References 22 publications

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“…Stress has been shown to influence not only neutrophil levels but also function [33], [34]. Moringa consumption, in several animal studies, positively influences many neutrophil functions including oxidative burst, chemotaxis, adhesion, and phagocytosis [35][36][37][38].…”

Section: Discussionmentioning

confidence: 99%

Moringa Oleifera Tea Alters Neutrophil but not Lymphocyte Levels in Blood of Acutely Stressed Mice

Drue¹,

Hurley²,

Minor³

2018

Madridge J Immunol

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Stress influences health and wellbeing, altering many physiological systems including the immune system. Herbal concoctions including teas impact immunity and mitigate the negative effects of stress. Moringa oleifera is a tree that is exceptionally rich in medicinally relevant and immune modulating nutrients and phytochemicals. The goal of this experiment was to determine whether tea prepared from dried Moringa oleifera leaves influenced acute stress induced changes to the levels of circulating lymphocyte and neutrophils. Balb/c mice were offered either water or Moringa tea ad libitum for four days and then randomly selected for either restraint for 1h or 12 h to induce stress or left alone (unstressed). Post stress the levels of circulating neutrophils and lymphocytesin the blood were determined by differential cell staining. While, mice that consumed water had significant (p<0.05) increases in circulating blood neutrophils after 1h of restraint, the level of neutrophils in the mice dosed with tea remained unchanged. Post 12h of restraint stress significant (p<0.05) increases in neutrophil levels were observed in mice that consumed tea but not in mice that consumed water. In the case of lymphocytes, consumption of Moringa tea had no effect. Compared to unstressed mice, 1 h or 12 h of restraint stress resulted insignificant (p<0.05) decreases in circulating lymphocytes of similar magnitude in both the water and Moringa tea groups. Flow cytometric analysis showed no significant differences in CD3+ T cells or CD19+ B cells levels. These data suggest that consumption of the Moringa tea can influence stress induced variations to circulating neutrophils but not lymphocytes.

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Section: Discussionmentioning

confidence: 99%

Moringa Oleifera Tea Alters Neutrophil but not Lymphocyte Levels in Blood of Acutely Stressed Mice

Drue¹,

Hurley²,

Minor³

2018

Madridge J Immunol

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“…The outcome of unrelieved psychological stress can be expressed in somatic complaints such as pain, fatigue, and headache and can lower the strength of the immune system, opening the body to infection and viruses (Tsukamoto & Machida, 2012; Westman, 2011). Psychological stress can also cause emotional difficulties such as hopelessness, depression, insomnia, and melancholy (Thoits, 2010).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Reflective Garden Walking on Adults With Increased Levels of Psychological Stress

Liehr

2015

J Holist Nurs

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“…Results from past studies showed cage crowding could result in high plasma IgG [26] and brain dopamine level [27]. The possibility of cage-to-cage migration causing alteration in concentrations of neurotransmitters and inflammatory mediators was then investigated.…”

Section: Resultsmentioning

confidence: 99%

Exposure to varied cage-size habitats alters pain sensitivity and inflammation-related biomarkers

Al¹,

Ko²,

Ks³

et al. 2020

Preprint

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Background Nature and size of rodent cages vary from one laboratory or country to another. Little is however known about the physiological implications of exposure to diverse cage sizes in animalbased experiment. Here, we exposed male Swiss mice to various cage sizes used across laboratories in Nigeria, top-rated paradigms were used to profile changes in physiological behaviours, and this was followed by evaluation of modified biochemical metrics. ResultsThe study showed a better systemic regulation of glucose metabolism in cage migrated mice compared to cage stationed. Strikingly, peripheral oxidative stress and pain sensitivity decreased significantly in cage-to-cage migrated mice despite increased pro-inflammation mediators (IL-6 and NF-κB) which contrast the norm reported in inflammatory conditions. Interestingly, emotion-linked behaviours, neurotransmitters (serotonin, noradrenaline and GABA) and body electrolytes were not altered by cage-to-cage migration.Conclusion Taken together, these results suggest that varied size cage-to-cage migration of experimental mice could affect targeted behavioural and biomolecular parameters of pain and inflammation, thus diminishing research reproducibility, precipitating false negative/positive results and leading to poor translational outcomes.

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Effects of life events and stress on neutrophil functions in elderly men

Cited by 14 publications

References 22 publications

Moringa Oleifera Tea Alters Neutrophil but not Lymphocyte Levels in Blood of Acutely Stressed Mice

Moringa Oleifera Tea Alters Neutrophil but not Lymphocyte Levels in Blood of Acutely Stressed Mice

The Effect of Reflective Garden Walking on Adults With Increased Levels of Psychological Stress

Exposure to varied cage-size habitats alters pain sensitivity and inflammation-related biomarkers

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