Relationships between inflammatory markers and suicide risk status in major depression

Ganança, Licínia; Galfalvy, Hanga; Cisneros-Trujillo, Sebastian; Basseda, Zahra; Cooper, Thomas B.; Ren, Xinguo; Figueira, Maria Luísa; Oquendo, María A.; Mann, J. John; Sublette, M. Elizabeth

doi:10.1016/j.jpsychires.2020.12.029

Cited by 27 publications

(13 citation statements)

References 80 publications

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“…Many researchers [6,18,[42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61] have attempted to identify biological markers that could be linked to suicidal behavior and potentially be used as additional preventive factors. Some of them tried to find the link between cytokines, such as TNF-α, IL-1β, and IL-6 and suicide [59,60]; others measured plasma phospholipid levels of arachidonic acid (AA%), docosahexaenoic acid (DHA%) and eicosapentaenoic acid (EPA%) [61]. Levels of thyroid thyroxine (T4), triiodothyronine (T3), thyroid-stimulating hormone (TSH), prolactin, and cortisol were also measured [51].…”

Section: Discussionmentioning

confidence: 99%

“…We have collected possible variants of changes in the level of lipids (total cholesterol very-low-density lipoprotein, low-density lipoprotein, high-density lipoprotein, and triglycerides) depending on the mental disorder in Table 1. There are other studies focused on the relationship between psychiatric disorders and serum lipid levels, like attention-deficit/hyperactivity disorder, obsessive-compulsive disorder, anxiety, or personality disorders [39,[60][61][62][63][64]. However, in our article we have limited our research to a specific timeframe, adult patients only, and mental illnesses such as depression, bipolar disorder, and schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

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Are Lipids Possible Markers of Suicide Behaviors?

Kułak-Bejda

Bejda

Lech

et al. 2021

JCM

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Suicides and suicidal behaviors are very important causes of mortality and morbidity and have become a serious global problem. More than 800,000 people die from suicide every year. Previous researches have established that lipids play an important role in the pathogenesis of suicide. Moreover, lipid levels might be a biological marker of suicide. A lot of researchers have tried to identify biological markers that might be related to depressive disorder, bipolar disorder or schizophrenia and suicidal behavior. It was also important to consider the usefulness of an additional tool for prevention actions. Metabolic deregulation, particularly low total cholesterol and low-density lipoproteins-cholesterol levels may cause higher suicide risk in patients with these psychiatric disorders.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Are Lipids Possible Markers of Suicide Behaviors?

Kułak-Bejda

Bejda

Lech

et al. 2021

JCM

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“…We found some preliminary evidence of elevated IL-1β among pregnant women with thoughts of suicide compared to those without suicidal thoughts. Previous research regarding the relationship between IL-1β and suicide has been inconclusive, with elevated IL-1β levels being associated with increased risk of suicide in some studies ( Bastos et al., 2017 ; Monfrim et al., 2014 ) but not others ( Achtyes et al., 2020 ; Ganança et al., 2020 ). Cassidy-Bushrow et al.…”

Section: Discussionmentioning

confidence: 96%

Are alterations in estradiol, cortisol, and inflammatory cytokines associated with depression during pregnancy and postpartum? An exploratory study

Szpunar

Malaktaris

Baca

et al. 2021

Brain, Behavior, & Immunity - Health

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Background Pregnant veterans are a subpopulation known to be at elevated risk of developing mental health symptoms, such as depression and suicidal ideation. Inflammation has been associated with depression, specifically during the perinatal period. Critical changes in estradiol, cortisol, and inflammatory cytokines are necessary for the progression of a healthy pregnancy, which are then rapidly altered in the postpartum period. We explored changes in estradiol, cortisol, and pro-inflammatory cytokines relative to depressive symptoms and suicidal thoughts across pregnancy and postpartum in this pilot and feasibility study. Methods We measured estradiol, cortisol, and the inflammatory cytokines IL-1β, IL-6, IL-8, IFN-γ, and TNF-α in 18 pregnant veterans and analyzed the data using descriptive statistics, dependent t-tests, and correlation analyses. We assessed depression severity with the Edinburgh Postnatal Depression Scale and suicidality with the Columbia-Suicide Severity Rating Scale. Thirteen of the women repeated assessments in the early postpartum period at an average of 6.7 weeks after birth. Results As anticipated, estradiol ( t (12) = 12.47, p < .001) and cortisol ( t (12) = 9.43, p < .001) significantly decreased from pregnancy to postpartum. There were no differences in the means of gestational and postpartum IL-1β, IL-6, TNF-α, or IFN-γ, but IL-8 was significantly increased from pregnancy to postpartum ( t (12) = −4.60, p = .001). Estradiol during pregnancy was positively correlated with IL-6 levels both during pregnancy ( r p = .656, p = .008) and postpartum ( r = 0.648, p = .023). Elevated IL-1β was associated with suicidal thoughts during pregnancy ( r = 0.529, p = .029). Although not statistically significant, depressive symptom severity trended towards a positive association with larger increases in IL-1β ( r = 0.535, p = .09) and TNF-α ( r = 0.501, p = .08) from pregnancy to postpartum. Conclusion This preliminary study suggests the feasibility of our approach for exploring a complex interplay between hormonal and pro-inflammatory changes from pregnancy to postpartum, and their relationship with depressive symptoms. Given our small sample and the relatively exploratory nature of our analyses, additional investigation focusing on hormonal and inflammatory changes and their potential associations with perinatal mental health is necessary to confirm and extend our preliminary findings and examine additional potential cova...

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“…In parallel is the negative affect associated with the self-perception of this condition [ 57 , 58 ]. These pathophysiological changes are also associated with increased suicidal thoughts [ 58 , 59 , 60 ]; conversely, dietary intervention appears to be a promising therapy to treat these disorders [ 61 , 62 ].…”

Section: Discussionmentioning

confidence: 99%

Usefulness of a Mobile Application (Mentali) for Anxiety and Depression Screening in Medical Students and Description of the Associated Triggering Factors

et al. 2022

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The impact of the COVID-19 health crisis on the mental health of the population requires the implementation of new primary screening strategies of mental health disorders to intervene in a timelier manner, and technology may provide solutions. We aimed to evaluate the usefulness of the mobile app Mentali (version 1.1.2; creators: Jorge Alfonso Solís Galván Sodel Vázquez Reyes, Margarita de la Luz Martínez Fierro, Perla Velasco Elizondo, Idalia Garza Veloz, Alejandro Mauricio González and Claudia Caldera Villalobos, Zacatecas, México) as a primary screening tool for anxiety and depression disorders in medical students and to assess the triggering risk factors. This was a descriptive and longitudinal study and included 155 Mexican medical students. Participants interacted with Mentali for 6 months. The mobile app integrated the Beck anxiety and depression inventories together with a mood module. At the end of the interaction, the students received psychological and psychiatric interventions to confirm their primary diagnoses. Symptoms of moderate/severe anxiety and depression were present in 62.6% and 54.6% of the studied population. When corroborating the diagnoses, Mentali obtained a sensitivity of 100%, 95%, and 43% to classify a mental health disorder, anxiety, and depression, respectively. The most important triggers found were as follows: belonging to a dysfunctional family, being introverted, and having suffered from bullying. The proportion of users with excellent/good mood decreased from 78.7% to 34.4% at the end of the semester, and the proportion of users who claimed to have bad/very bad mood increased from 7.4% to 34.4% at the end of the semester (p < 0.05). Mentali was useful for identifying users with anxiety and/or depression, and as an auxiliary tool to coordinate the provision of specialized interventions, allowing us to increase the proportion of patients who needed psychological care and received it by 30%. The efficacy of Mentali in identifying activities through time with an impact on the mood and mental health of the users was confirmed. Our results support the use of Mentali for the primary screening of mental health disorders in young adults, including medical students.

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Relationships between inflammatory markers and suicide risk status in major depression

Cited by 27 publications

References 80 publications

Are Lipids Possible Markers of Suicide Behaviors?

Are Lipids Possible Markers of Suicide Behaviors?

Are alterations in estradiol, cortisol, and inflammatory cytokines associated with depression during pregnancy and postpartum? An exploratory study

Usefulness of a Mobile Application (Mentali) for Anxiety and Depression Screening in Medical Students and Description of the Associated Triggering Factors

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