Are Lipids Possible Markers of Suicide Behaviors?

Kułak-Bejda, Agnieszka; Bejda, Grzegorz; Lech, Magdalena; Waszkiewicz, Napoleon

doi:10.3390/jcm10020333

Cited by 19 publications

(15 citation statements)

References 64 publications

(146 reference statements)

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“…Moreover, a study by Koweszko and colleagues [30] found that there was a positive relationship between the number and intensity of suicide attempts and advanced oxidation protein products (AOPPs), advanced glycation end products (AGE), and a lack of CAT activity in a group of psychiatric inpatients who were hospitalised due to various psychiatric diagnoses. The widely known potential markers of suicide behaviours, such as blood lipids, which may also change due to the oxidative stress reaction, were described by Kułak-Bejda and colleagues [31].…”

Section: Oxidative Stress Markersmentioning

confidence: 99%

Ordering Knowledge in the Markers of Psychiatric/Mental Disorders

Waszkiewicz

2022

JCM

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Section: Oxidative Stress Markersmentioning

confidence: 99%

Ordering Knowledge in the Markers of Psychiatric/Mental Disorders

Waszkiewicz

2022

JCM

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Section: Association Between Cholesterol and Suicidalitymentioning

confidence: 99%

“…In contrast, other studies suggest that the association between serum lipid concentrations and suicide attempt in patients with MDD is controversial and inconsistent [ 28 ]. Bartoli et al (2017) [ 29 ] showed that subjects with a history of suicide attempt (174.0 ± 45.7 mg/dL) and without suicide attempts (193.9 ± 42.6 mg/dL) presented no significant difference in total cholesterol, LDL, or triglyceride levels [ 28 , 30 ]. However, other researchers have suggested that patients who attempted suicide had higher concentrations of CT, LDL-C, and TG than those who did not attempt suicide [ 31 ], besides, MDD subjects who attempted suicide had significantly higher HDL-C levels [ 32 ].…”

Section: Association Between Cholesterol and Suicidalitymentioning

confidence: 99%

Possible Association of Cholesterol as a Biomarker in Suicide Behavior

et al. 2021

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Suicides and suicidal behavior are major causes of mortality and morbidity in public health and are a global problem. Various authors have proposed changes in lipid metabolism (total cholesterol decrease) as a possible biological marker for suicidal behavior. The objective of this study was to review the studies that have demonstrated a relationship between serum cholesterol levels and suicidal behavior and to describe the possible pathophysiological mechanisms that associate changes in cholesterol concentration and suicidal behavior. Relevant literature related to serum cholesterol levels and suicidal behavior was identified through various database searches. The data from the existing literature present the findings that relate low cholesterol levels and possible pathophysiological mechanisms (neuroinflammation, serotonergic neurotransmission), genes related to cholesterol synthesis, pharmacological treatments that alter lipid metabolism and the possible participation in suicidal behavior. Nevertheless, future research is required to describe how serum cholesterol affects cholesterol metabolism in the CNS to establish and understand the role of cholesterol in suicidal behavior.

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“…Many studies have been conducted on the causes of suicide [5][6][7][8][9][10][11]. These studies have typically investigated the psychiatric, sociological, economic, and biological components of suicidal behavior.…”

Section: Introductionmentioning

confidence: 99%

Investigation of polymorphic variants of SLC6A4, TPH-1, and TPH-2 genes in cases of completed suicide

Kilicaslan,

Cumaogullari,

Emiral

et al. 2022

J. Mens. Health

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Background and objective: Serotonin plays an important role in the pathophysiology of aggressive behavior. Low serotonin levels and altered functions of serotonin receptors affect suicidal behavior.TPH-1, TPH-2 and SLC6A4 genes have important roles in serotonin production and degradation pathways. In this study, polymorphic variants of the TPH-1, TPH-2 and SLC6A4 genes, rs1800532, rs7305115, rs6355 and rs1386494, were investigated in 100 completed suicides and 100 healthy individuals. Materials and methods:After DNA isolation, a new polymerase chain reaction technology KASP TM (Competitive allele-specific polymerase chain reaction method), was used in the genotyping of the selected gene variants.Results: No statistically significant difference was found for the genotype and individual allele frequencies of the polymorphic variants between suicide and control groups, as well as between men and women in suicide cases. However, we observed non-significant tendencies of increased minor alleles in suicidal men for all TPH SNPs. Conclusions:More molecular genetic research studies are needed to understand the pathophysiology of suicide and to reveal its relationship with gender.

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Are Lipids Possible Markers of Suicide Behaviors?

Cited by 19 publications

References 64 publications

Ordering Knowledge in the Markers of Psychiatric/Mental Disorders

Ordering Knowledge in the Markers of Psychiatric/Mental Disorders

Possible Association of Cholesterol as a Biomarker in Suicide Behavior

Investigation of polymorphic variants of SLC6A4, TPH-1, and TPH-2 genes in cases of completed suicide

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