Relationships between folate and inflammatory features of asthma

Lin, Jenny H.; Matsui, William; Aloe, Charles; Peng, Roger D.; Diette, Gregory B.; Breysse, Patrick N.; Matsui, Elizabeth C.

doi:10.1016/j.jaci.2012.10.046

Cited by 16 publications

(29 citation statements)

References 13 publications

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“…There was no significant association between serum folate and asthma or wheezing at age 6 years. Another study by the same group examined serum folate and disease severity or control in 144 inner-city children (aged 5-17 yr) with persistent asthma over 1 year of follow-up (27). In this study, children with a folate level in the second quartile had a total IgE that was higher than those with a folate level in the lowest quartile but not significantly different from those in the third or fourth quartile.…”

Section: Epidemiologic Studies Of Folate Status and Asthma Or Atopymentioning

confidence: 96%

“…Small sample size, potential selection bias due to substantial loss of follow-up of original study participants, nonassessment of dietary intake, and limited adjustment for potential confounders Lin et al (27) Prospective study of 144 inner-city U.S. children with persistent asthma (aged 5-17 yr) followed for 1 yr An association between MTHFR C677T genotype and atopy or atopic asthma was reported in studies in Denmark (41) and China (42) but not replicated in subsequent studies in Denmark (15) and the United Kingdom (34). Among 1,482 Danish adults, subjects who were homozygous for the T allele of the C677T mutation in MTHFR had increased odds of atopy (aOR ¼ 1.8, 95% CI ¼ 1.2-2.6, P , 0.01) (41).…”

Section: Gene-by-folate Interactions On Asthma or Atopymentioning

confidence: 99%

See 1 more Smart Citation

Folate and Asthma

Blatter

Han

Forno

et al. 2013

Am J Respir Crit Care Med

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Section: Epidemiologic Studies Of Folate Status and Asthma Or Atopymentioning

confidence: 96%

Section: Gene-by-folate Interactions On Asthma or Atopymentioning

confidence: 99%

Folate and Asthma

Blatter

Han

Forno

et al. 2013

Am J Respir Crit Care Med

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“…However, few studies have examined whether folate status is associated with disease morbidity or disease severity in subjects with established asthma; whether folate status affects asthma control in individuals who already have asthma is also unclear 10,12 . Low folate levels have been shown to be associated with increased risks of wheeze, atopy, severe asthma exacerbations, or an elevated total IgE in cross-sectional studies of children and adults 13,14,15 .…”

Section: Introductionmentioning

confidence: 99%

Serum folate concentrations, asthma, atopy, and asthma control in Peruvian children

Nicholson

Pollard

Lima

et al. 2017

Respiratory Medicine

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Background The relationship between folate status and asthma-related outcomes has not been carefully examined in low- and middle-income countries where folate deficiency is common. Methods Ancillary analysis of an unmatched case-control study in which we analyzed serum folate concentrations in 412 children with asthma and 342 controls living in peri-urban communities in Lima, Peru. We examined baseline associations between folate and asthma, atopy, total serum IgE, pulmonary function, and fractional exhaled nitric oxide. We then followed children with asthma longitudinally for 6–9 months and assessed associations between folate and odds of uncontrolled asthma (defined as Asthma Control Test score ≤ 19) and of ≥1 emergency visits during follow-up. Results A 10 ng/mL decrease in serum folate was associated with 45% higher adjusted odds of asthma (OR=1.45, 95% CI 1.05–2.02). The folate-asthma relationship differed by atopic status: a 10 ng/mL decrease in serum folate was associated with a 2.4-fold higher odds of asthma among children without atopy (2.38, 1.20–4.72) and 23% higher odds of asthma in children with atopy (1.23, 0.85–1.80). Among children with asthma, a 10 ng/mL decrease in serum folate was associated with 62% higher odds of uncontrolled asthma (1.62, 1.02–2.56) and 73% higher odds of ≥1 emergency visits during follow-up (1.73, 1.05–2.85). Conclusions Serum folate concentrations were inversely associated with asthma, but this effect was stronger in children without atopy. Among children with asthma, lower serum folate concentrations were associated with higher risk of uncontrolled asthma.

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“…While some studies found that prenatal folic acid supplementation was associated with more asthma, wheeze, and other respiratory problems in early childhood [90,91], others did not find an association [92][93][94]. Whether folate status affects disease severity or control in people who already suffer from asthma is also unclear [95]. Given its protective effects against neural tube and cardiac defects, there is no reason to alter current recommendations for folic acid supplementation during conception and pregnancy based on the findings on folate in asthma [96].…”

Section: Effects Of Diet On Epigenetic Regulation In Bronchial Asthmamentioning

confidence: 99%

Dietary or Supplementary Intake Modulates Inflammatory Response in Asthma Response in Asthma

Matsumura¹

2015

Glob J Allergy

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SummaryThe importance of diet and supplement intake in the onset and development of asthma has been advocated recently, and it may be important in the prevention and management of bronchial asthma. Long-chain n-3 polyunsaturated fatty acids (LCn3PUFAs), vitamins (Vit), choline, and probiotics may be candidates to reduce medication use and provide some protection from risk. Experimental studies of diet in bronchial asthma have demonstrated modification of pulmonary function and the immune system through mechanisms involving antioxidant effect, T-helper (Th) 2 and Th17 inhibition, tolerogenic regulatory T cell (Treg) function promotion, nuclear transcription factors and epigenetic regulation. Although studies in animal models have provided evidence of supportive effects of diet in asthma, there have been few longitudinal studies of dietary or supplement intake and asthma, and the available epidemiological data remain controversial and inconclusive.prevalence of asthma and allergy in their offspring [20]. Cord serum 25-Hydroxyvitamin D level was inversely associated with the risk of transient early wheezing by the age of 5 years, but no association was found with asthma [21]. Recent published data demonstrated that Vit D3 did not reduce the rate of first treatment failure or exacerbation in adults with persistent asthma and Vit D insufficiency, suggesting that therapeutic Vit D3 supplementation in patients with symptomatic asthma was not useful [22].

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Relationships between folate and inflammatory features of asthma

Cited by 16 publications

References 13 publications

Folate and Asthma

Folate and Asthma

Serum folate concentrations, asthma, atopy, and asthma control in Peruvian children

Dietary or Supplementary Intake Modulates Inflammatory Response in Asthma Response in Asthma

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