Folate and Asthma

Blatter, Joshua; Han, Y.-Y.; Forno, Erick; Brehm, John M.; Bodnar, Lisa M.; Celedón, Juan C.

doi:10.1164/rccm.201302-0317pp

Cited by 37 publications

(43 citation statements)

References 44 publications

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“…Studies on folic acid intake during pregnancy and asthma in children have also generally found no association between the two [82][83][84][85]. According to several large birth cohort studies, vitamin D intake or plasma levels during pregnancy are generally not associated with childhood asthma or lung function [86][87][88][89], and an RCT examining the effects of vitamin D supplementation during pregnancy (n5180) found no significant difference in children's wheezing at 3 years of age [90].…”

Section: Early-life Origins Of Chronic Respiratory Diseases | S Carrmentioning

confidence: 99%

Early-life origins of chronic respiratory diseases: understanding and promoting healthy ageing

et al. 2014

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Chronic obstructive respiratory disorders such as asthma and chronic obstructive pulmonary disease often originate early in life. In addition to a genetic predisposition, prenatal and early-life environmental exposures have a persistent impact on respiratory health. Acting during a critical phase of lung development, these factors may change lung structure and metabolism, and may induce maladaptive responses to harmful agents, which will affect the whole lifespan.Some environmental factors, such as exposure to cigarette smoke, type of childbirth and diet, may be modifiable, but it is more difficult to influence other factors, such as preterm birth and early exposure to viruses or allergens.Here, we bring together recent literature to analyse the critical aspects involved in the early stages of lung development, going back to prenatal and perinatal events, and we discuss the mechanisms by which noxious factors encountered early on may have a lifelong impact on respiratory health.We briefly comment on the need for early disease biomarkers and on the possible role of ''-omic'' technologies in identifying risk profiles predictive of chronic respiratory conditions. Such profiles could guide the ideation of effective preventive strategies and/or targeted early lifestyle or therapeutic interventions. @ERSpublications Early-life factors have a role in onset of asthma and COPD; early postnatal interventions may promote lung health http://ow.ly/BvUrx

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Section: Early-life Origins Of Chronic Respiratory Diseases | S Carrmentioning

confidence: 99%

Early-life origins of chronic respiratory diseases: understanding and promoting healthy ageing

et al. 2014

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“…This literature has been summarized, in several reviews, as conflicting, with limitations caused by heterogeneity in classification of folate intake, the time periods considered for exposure and disease development, and outcome definitions (5)(6)(7)(8). Two more recent studies reported associations between asthma in children older than 4 years of age and the use of folic acid supplements containing 1,000 mg or more during pregnancy (9,10).…”

mentioning

confidence: 99%

Maternal Folate Intake during Pregnancy and Childhood Asthma in a Population-based Cohort

Parr

Magnus

Karlstad³

et al. 2017

Am J Respir Crit Care Med

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Rationale: A potential adverse effect of high folate intake during pregnancy on children's asthma development remains controversial.Objectives: To prospectively investigate folate intake from both food and supplements during pregnancy and asthma at age 7 years when the diagnosis is more reliable than at preschool age.Methods: This study included eligible children born [2002][2003][2004][2005][2006] from the Norwegian Mother and Child Cohort Study, a populationbased pregnancy cohort, linked to the Norwegian Prescription Database. Current asthma at age 7 was defined by asthma medications dispensed at least twice in the year (1,901 cases; n = 39,846) or by maternal questionnaire report (1,624 cases; n = 28,872). Maternal folate intake was assessed with a food frequency questionnaire validated against plasma folate. We used log-binomial and multinomial regression to calculate adjusted relative risks with 95% confidence intervals.Measurements and Main Results: Risk of asthma was increased in the highest versus lowest quintile of total folate intake with an adjusted relative risk of 1.23 (95% confidence interval, 1.06-1.44) that was similar for maternally reported asthma. Mothers in the highest quintile had a relatively high intake of food folate (median, 308; interquartile range, 241-366 mg/d) and nearly all took at least 400 mg/d of supplemental folic acid (median, 500; interquartile range, 400-600 mg/d). Conclusions:In this large prospective population-based cohort with essentially complete follow-up, pregnant women taking supplemental folic acid at or above the recommended dose, combined with a diet rich in folate, reach a total folate intake level associated with a slightly increased risk of asthma in children.

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“…The evidence collated in several recent systematic reviews is that maternal folic acid supplementation at the usual doses of 0.4-0.5 mg/d during the periconceptional period before conception and during the first trimester of pregnancy is not associated with increased rates of childhood asthma (Blatter et al 2013, Crider et al 2013, Brown et al 2014. There is some evidence that higher doses of folic acid during pregnancy are associated with asthma, based on linkage of maternal and children pharmacy dispensing data for >39 000 pregnancies in the Netherlands (Zetstra-van der Woude et al 2014).…”

Section: Evidence For Methyl Donor Abundance As An Asthma and Allergymentioning

confidence: 99%

Pre-birth origins of allergy and asthma

Gatford¹,

Wooldridge

Kind

et al. 2017

Journal of Reproductive Immunology

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Highlights Key points (3-5 dot points, max 85 characters including spaces)  Prenatal exposures alter later disease risk, including for allergy  Epidemiological and experimental evidence suggests IUGR protects against allergy  Elevated methyl donor abundance in late pregnancy may predispose progeny to allergy  Maternal asthma and allergy during pregnancy predispose progeny to allergy Abstract: Allergy is a chronic disease that can develop as early as infancy, suggesting that early life factors are important in its aetiology. Variable associations between size at birth, a crude marker of the fetal environment, and allergy have been reported in humans and require comprehensive review. Associations between birth weight and allergy are however confounded in humans, and we and others have therefore begun exploring the effects of early life events on allergy in experimental models. In particular, we are using ovine models to investigate whether and how a restricted environment before birth protects against allergy, whether methyl donor availability contributes to allergic protection in IUGR, and why maternal asthma during pregnancy is associated with increased risks of allergic disease in children. We found that experimental intrauterine growth restriction (IUGR) in sheep reduced cutaneous responses to antigens in progeny, despite normal or elevated IgE responses. Furthermore, maternal methyl donor supplementation in late pregnancy partially reversed effects of experimental IUGR, consistent with the proposal that epigenetic pathways underlie some but not all effects of IUGR on allergic susceptibility. Ovine experimental allergic asthma with exacerbations reduces relative fetal size in late gestation, with some changes in immune populations in fetal thymus suggestive of increased activation. Maternal allergic asthma in mice also predisposes progeny to allergy development. In conclusion, these findings in experimental models provide direct evidence that a perturbed environment before birth alters immune system development and postnatal function, and provide opportunities to investigate underlying mechanisms and develop and evaluate interventions.

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Folate and Asthma

Cited by 37 publications

References 44 publications

Early-life origins of chronic respiratory diseases: understanding and promoting healthy ageing

Early-life origins of chronic respiratory diseases: understanding and promoting healthy ageing

Maternal Folate Intake during Pregnancy and Childhood Asthma in a Population-based Cohort

Pre-birth origins of allergy and asthma

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