Relationships Between Blood Lipid and Blood Protein Levels in the Nephrotic Syndrome

Serum Lipid and Lipoprotein Alterations in Nephrosis

“…It has not been established conclusively, however, that the hyperlipidemia is caused by hypoalbuminemia, and irregularities in the relationship between levels of serum lipids and serum albumin have been pointed out repeatedly (2)(3)(4)(5).…”

Comparative study of lipid profile abnormalities in first episode and relapse cases of childhood nephrotic syndrome

“…20 Thomas et al found correlation between serum cholesterol and albumin. 21 It is due to hepatic lipoprotein synthesis is stimulated in response to …”

A Study of Serum Lipids in Nephrotic Syndrome in Children

“…Heymann et al, found no correlation between the developmental of hyperlipidemia and hypoalbuminemia and postulated that the severity of hyperlipidemia is related to the amount of nephrotic kidney tissue present [12] . Thomas et al found correlation between serum cholesterol and albumin and did not find correlation between serum cholesterol and globulin and total protein [3] .…”

“…Although pathophysiological aspects of hyperlipidemia have not been completely identified, hypoalbuminemia, increased lipoprotein synthesis and decreased lipoprotein lipase activity are described by various workers [2] . Some degree of correlation between lipids and serum albumin has been suggested by Thomas et al [3] and between lipidemia and oedema by Peters et al [4] Lipoproteins play an important role in the transport of plasma lipids; their increase or alteration in various fractions may be responsible for hypercholesterolemia, in nephrotic syndrome [2] . There is increased total cholesterol, LDL cholesterol, VLDL cholesterol and triglycerides and normal or low HDL cholesterol [5] .…”