Relationships between antithrombogenicity and surface free energy of regenerated silk fibroin films

Park, Won Ho; Ha, Wan Shik; Ito, Harumi; Miyamoto, Takeaki; Inagaki, Hiroshi; Noishiki, Yasuharu

doi:10.1007/bf02875259

Cited by 45 publications

(31 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, SF has been increasingly studied for new biomedical applications due to its biocompatibility, slow degradability, remarkable mechanical properties, low inflammatory responses, and good oxygen and water vapor permeability of the material [63,64]. In addition, it was found that SF had a good anti-thrombogenicity and absorbability even though the polymer showed foreign body reaction [65]. Pure SF nanofibers can be made by electrospinning of SF in formic acid [66].…”

Section: Electrospinning Of Blends Of Chitosan and Proteinsmentioning

confidence: 99%

Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning

Sun¹,

Li²

2011

Express Polym. Lett.

209

101

View full text Add to dashboard Cite

Chitosan is soluble in most acids. The protonation of the amino groups on the chitosan backbone inhibits the electrospinnability of pure chitosan. Recently, electrospinning of nanofibers based on chitosan has been widely researched and numerous nanofibers containing chitosan have been prepared by decreasing the number of the free amino groups of chitosan as the nanofibiers have enormous possibilities for better utilization in various areas. This article reviews the preparations and properties of the nanofibers which were electrospun from pure chitosan, blends of chitosan and synthetic polymers, blends of chitosan and protein, chitosan derivatives, as well as blends of chitosan and inorganic nanoparticles, respectively. The applications of the nanofibers containing chitosan such as enzyme immobilization, filtration, wound dressing, tissue engineering, drug delivery and catalysis are also summarized in detail

show abstract

Section: Electrospinning Of Blends Of Chitosan and Proteinsmentioning

confidence: 99%

Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning

Sun¹,

Li²

2011

Express Polym. Lett.

209

101

View full text Add to dashboard Cite

show abstract

“…[2][3][4][5] Besides its utility as a textile fiber, many researchers have recently investigated SF as one of candidate materials for biomedical applications because it has several useful properties including good biocompatibility, good oxygen and water vapor permeability, biodegradability, and minimal inflammatory reaction. [6][7][8] Practically, SF has been used in various fields such as cosmetics, medical materials for human health, and food additives.…”

mentioning

confidence: 99%

Silk Fibroin Nanofiber. Electrospinning, Properties, and Structure

Kim

Nam

Lee

et al. 2003

Polym J

Self Cite

220

View full text Add to dashboard Cite

ABSTRACT:An electrospinning process was used to fabricate silk fibroin (SF) nanofiber nonwovens for wound dressing applications. The electrospinning of regenerated SF was performed with formic acid as a spinning solvent. For crystallization, as-spun SF nanofiber nonwovens were chemically treated with an aqueous methanol solution of 50%. The morphology, porosity and conformational structures of as-spun and chemically treated SF nanofibers were investigated by scanning electron microscopy (SEM), mercury porosimetry, wide angle X-Ray diffraction (WAXD), attenuated total reflectance infrared spectroscopy (ATR-IR), solid state 13 C CP/MAS nuclear magnetic resonance (NMR) spectroscopy. SEM micrograph showed that the electrospun SF nanofibers had an average diameter of 80 nm and a distribution in diameter ranging from 30 to 120 nm. The porosity of as-spun SF nanofiber nonwovens was 76.1%, indicating it was highly porous. Conformational transitions of the as-spun SF nanofibers from random coil to β-sheet by aqueous methanol treatment occurred rapidly within 10 min, confirmed by solid-state 13 C NMR, ATR-IR, and X-Ray diffraction. KEY WORDS Silk Fibroin / Electrospinning / Nanofiber / Nonwovens / Conformation / Porosity / β−Sheet / Random Coil / Silk as a typical fibrous protein is produced by a variety of insects including silkworm. Among the native silk proteins, the silkworm silk, mostly that of the domesticated Bombyx mori, has been used as high-quality textile fiber and suture for a long time. B. mori silk consists of two types of proteins, fibroin and sericin. Fibroin is the protein that forms the filaments of silkworm silk and gives silk its unique physical and chemical properties. 1 Sericins are the group of gummy proteins which bind the fibroin filaments. Silk fibroin (SF) can be used in various forms, such as gels, powders, fibers, or membranes, depending on application. 2-5 Besides its utility as a textile fiber, many researchers have recently investigated SF as one of candidate materials for biomedical applications because it has several useful properties including good biocompatibility, good oxygen and water vapor permeability, biodegradability, and minimal inflammatory reaction. 6-8 Practically, SF has been used in various fields such as cosmetics, medical materials for human health, and food additives.Recently, much attention has been paid to electrospinning process as an unique technique because it can produce polymer nanofibers with diameter in the range from several micrometer down to tens of nanometers, depending on the polymer and processing conditions. In electrospinning, a high voltage is applied to create electrically charged jets of a polymer solution. These jets dry to form nanofibers, which are collected on a target as nonwovens. These nanofibers are of considerable interest for various kinds of applications, because they have several unique properties such as high specific surface area and high porosity. Examples are fiber membranes for filter applications, 9 biomedical applications such as wou...

show abstract

“…[39][40][41] Min et al 42 electro spun silk fibroin using formic acid as a solvent and studied its effect on adhesion and spreading of normal human keratinocytes and fibroblasts. Jin et al 43 used various compositions of silk/ polyethylene oxide (PEO) aqueous blends in electro spinning and investigated the potential as biomaterial scaffold.…”

Section: Biological Polymersmentioning

confidence: 99%

Nano Fibres by Electro spinning: Properties and Applications

Nayak¹,

Padhye²

2017

JTEFT

View full text Add to dashboard Cite

Electro spinning is a simple and versatile technique applicable to a wide range of polymers and solvents for the production of materials in nanometer scale. The nano fibrous materials produced by electro spinning process exhibit novel and significantly improved physical, chemical and biological properties. The small fibre diameter and the porous structure of the electrospun surfaces enable them for a wide range of applications such as wound dressing, tissue engineering scaffolds, vascular grafts, filters, membranes and sensors. In this article the principle, setup, materials used and the factors affecting the electro spinning process have been described. Also the properties & applications of electrospun fibres and the limitations & future scope of electro spinning process have been highlighted.

show abstract

Relationships between antithrombogenicity and surface free energy of regenerated silk fibroin films

Cited by 45 publications

References 15 publications

Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning

Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning

Silk Fibroin Nanofiber. Electrospinning, Properties, and Structure

Nano Fibres by Electro spinning: Properties and Applications

Contact Info

Product

Resources

About