Relationships Between Angry-Impulsive Personality Traits and Genetic Polymorphisms of the Dopamine Transporter

Mesocorticolimbic dopamine functioning in primary psychopathy: A source of within-group heterogeneity

“…Therefore, samples that include both children and adolescents, or that do not differentiate between different age groups, fail to find a significant association between DAT1 and externalizing or impulsive behavior (Schulz-Heik et al, 2008;Sonuga-Barke et al, 2009;Richards et al, 2014). When transitioning into adulthood and DA levels steadily decline again, it is the 9R-allele that is associated with angry-impulsive personality traits, more severe ADHD symptoms, and increased levels of antisocial behavior in addicts (Gerra et al, 2005;Franke et al, 2008;Joyce et al, 2009;Franke et al, 2010;Reese et al, 2010;Yang et al, 2012). The pattern here suggests that at normative ranges of DA activity or D2S-receptor activation as found in children and adults, the 9R-allele is more strongly associated with externalizing and antisocial behavior, whereas at higher ranges of DA activity and D2-receptor subsensitivity as found in adolescents, it is the 10R-allele that is associated with antisocial and aggressive behaviors.…”

The dopamine transporter gene may not contribute to susceptibility and the specific personality traits of amphetamine dependence

“…The DAT1 gene was reported to effect personality traits in healthy controls (Kazantseva et al, 2011;Shibuya et al, 2009) and patients with mood disorder (Huang et al, 2011;Joyce et al, 2009), but there are no available data of personality-gene interactions in AD patients. The present study assessed the personality traits of AD patients using the Tridimensional Personality Questionnaire (TPQ) to determine whether specific personality and gene-personality interactions are involved in the pathogenesis of AD.…”

Dopaminergic control of anxiety in young and aged zebrafish

“…DAT polymorphisms are associated with extreme behavioral traits and disorders, including angry-impulsive personality and borderline personality disorder (Joyce et al, 2009, n.d.), binge-eating (Shinohara et al, 2004), disruptive behavior disorder (Lee et al, 2007), attention-deficit and hyperactivity disorder (Franke et al, 2008) and alcohol dependence (Ueno et al, 1999). …”