The dopamine transporter gene may not contribute to susceptibility and the specific personality traits of amphetamine dependence

Tzeng, Nian Sheng; Lu, Ru Band; Yeh, Hui Wen; Yeh, Yi‐Wei; Huang, Chang Chih; Kuo, Shin Chang; Chen, Chun‐Yen; Chang, Hsin‐An; Ho, Pei‐Shen; Cheng, Serena; Shih, Mei Chen; Huang, San Yuan

doi:10.1016/j.drugalcdep.2015.01.030

Cited by 14 publications

(8 citation statements)

References 43 publications

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“…Although evidence of associations between two SLC6A3 intronic variants (rs464049 and rs37020) and NS was found, the findings were not significant following corrections for multiple testing. However, our finding that there is no association is comparable to previous studies that did not find evidence of association in patients with substance use disorders such as amphetamine dependence [ 52 ] and heroin dependence [ 53 ]. Anghelescu and colleagues proposed that the 3′ VNTR polymorphism of the SLC6A3 gene may affect NS in Caucasian patients with AD.…”

Section: Discussionsupporting

confidence: 86%

The SLC6A3 gene possibly affects susceptibility to late-onset alcohol dependence but not specific personality traits in a Han Chinese population

et al. 2017

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Dopaminergic dysfunction has an important role in the pathoetiology of alcohol dependence (AD). The purpose of this study was to determine whether the solute carrier family 6 member 3 (SLC6A3) gene (also known as the dopamine transporter DAT gene) was associated with AD, and whether variants in the SLC6A3 locus were associated with specific personality traits in patients with AD. Sixteen polymorphisms in SLC6A3 were analyzed using 637 patients with AD and 523 healthy controls. To reduce clinical heterogeneity, patients were classified into two subgroups: early-onset AD (EOAD) and late-onset AD (LOAD). The Tridimensional Personality Questionnaire was used to assess the personality traits novelty seeking (NS) and harm avoidance (HA) in the patients with AD. Using allele frequency and genotype distribution comparisons and logistic regression analysis, we found evidence of association between rs6350 and AD (P < 0.05). Following subgroup analysis, we confirmed evidence of an association in patients with LOAD (P = 0.003), but not in patients with EOAD. Heterozygous carriers of the A allele have a nearly 3 times greater risk to develop LOAD compared to individuals who do not have an A allele. Although we found that patients with AD had higher NS and HA scores compared to controls (P < 0.001), we did not find evidence of association between SLC6A3 polymorphisms and either NS or HA in patients with AD using linear regression analysis. The findings from our study indicate that the SLC6A3 gene may have a role in susceptibility to late-onset AD in the Han Chinese population.

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Section: Discussionsupporting

confidence: 86%

The SLC6A3 gene possibly affects susceptibility to late-onset alcohol dependence but not specific personality traits in a Han Chinese population

et al. 2017

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“…In fact, novelty seeking is the characteristics of sensation‐seeking personality in humans, and higher novelty seeking would predict the initiation of drug use, subsequent compulsive use, and the risk to relapse . Our finding is consistent with previous substance‐related studies, including alcohol, amphetamine, cocaine, tobacco, and cannabis . In addition, our study found a negative correlation between NS score and age in patients with HD, implying that adolescents display higher levels of novelty seeking than do adults, and may have higher risk for developing substance dependence …”

Section: Discussionsupporting

confidence: 90%

NGF gene polymorphisms are not associated with heroin dependence in a Taiwanese male population

et al. 2018

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“…A higher novelty seeking score is one of the most relevant individual factors associated with higher impulsivity, excitability, and behavioral disinhibition [38]; higher novelty seeking would predict the initiation of drug use, subsequent vulnerability to compulsive use, and a higher propensity to relapse [39]. In this study, patients with HD had higher NS traits; this was consistent with our previous studies of patients with amphetamine or alcohol dependence [40,41]. However, when we divided the HD subjects who completed the TPQ into subgroups defined on the basis of the age of onset, and only the patients with early onset HD had significantly higher NS scores than controls.…”

Section: Novelty Seeking Personality Trait As a Risk Factor For Earlysupporting

confidence: 91%

Do NeuroD Gene Polymorphisms Predict the Risk of Heroin Dependence or Mediate the Association between Personality Traits and Heroin Dependence?

Tsou¹,

Kuo²,

Huang³

et al. 2017

Neuropsychiatry

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Objective: Heroin dependence (HD) affects brain development and is known to be heritable. The NeuroD gene encodes a neuroge nic differentiation factor, and its expression is essential for the development of the central nervous system. In this genetic case-control study, we aimed to investigate whether NeuroD gene polymorphisms associate with the occurrence of HD and the specific personality traits of patients with HD. Methods: 1107 unrelated participants (584 patients with HD and 523 controls) were recruited to the study The patients with HD were classified into six clinical subgroups based on their gender, duration, and age of onset to reduce heterogeneity. In total, 539 subjects completed the personality trait assessments. Results: We found a weak association between the NeuroD 1 rs16867467 locus and HD (p=0.048); this weak association was found only in the male (p=0.039) and late onset (p=0.047) HD subgroups. These findings could not be confirmed after haplotype analysis and Bonferroni corrections for multiple comparisons. Patients with HD had higher novelty seeking (NS) and harm avoidance (HA) scores than healthy subjects. However, none of the polymorphisms in the NeuroD gene affected the NS and HA scores in both patients and healthy subjects (p>0.05). A negative correlation was found between age and novelty seeking scores in both groups, suggesting novelty seeking personality trait as a risk factor for early-onset HD. Conclusion: This study suggests that the NeuroD gene may neither contribute to the risk of HD nor mediate the relationship between specific personality traits and HD.

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The dopamine transporter gene may not contribute to susceptibility and the specific personality traits of amphetamine dependence

Cited by 14 publications

References 43 publications

The SLC6A3 gene possibly affects susceptibility to late-onset alcohol dependence but not specific personality traits in a Han Chinese population

The SLC6A3 gene possibly affects susceptibility to late-onset alcohol dependence but not specific personality traits in a Han Chinese population

NGF gene polymorphisms are not associated with heroin dependence in a Taiwanese male population

Do NeuroD Gene Polymorphisms Predict the Risk of Heroin Dependence or Mediate the Association between Personality Traits and Heroin Dependence?

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