Relationships Among the Metabolic Syndrome, Bone Mineral Density, Bone Turnover Markers, and Hyperglycemia

Terzi, Rabia; Dindar, Sevim; Terzi, Hasan; Demirtaş, Ömer

doi:10.1089/met.2014.0074

Cited by 17 publications

(13 citation statements)

References 26 publications

(31 reference statements)

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“…In addition, although postmenopausal women exhibit high levels of bone resorption markers [15, M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 14 55], given their high bone turnover, it has recently been reported that suppression of bone turnover increases the fracture risk in postmenopausal women with T2D [17,54], which is consistent with our results. Furthermore, although bisphosphonate (an inhibitor of bone resorption) is typically used to treat osteoporosis, it is less effective for patients with T2D [56].…”

Section: Accepted Manuscriptsupporting

confidence: 90%

“…Interestingly, low bone turnover and bone deficiency in T2D is thought to be caused by elevated glycemic levels, based on a study of bone metabolic markers [54]. In addition, although postmenopausal women exhibit high levels of bone resorption markers [15, M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 14 55], given their high bone turnover, it has recently been reported that suppression of bone turnover increases the fracture risk in postmenopausal women with T2D [17,54], which is consistent with our results.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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Association between basal metabolic function and bone metabolism in postmenopausal women with type 2 diabetes

et al. 2015

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Section: Accepted Manuscriptsupporting

confidence: 90%

Section: Accepted Manuscriptmentioning

confidence: 99%

Association between basal metabolic function and bone metabolism in postmenopausal women with type 2 diabetes

et al. 2015

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“…It was indicated that hyperglycemia was negatively associated with lumbar BMD (36). It has been demonstrated that endogenous GLP-1 could help maintain a normal glycemic level acting through GLP-1 receptors (37).…”

Section: The Potential Mechanisms Of the Glp-1 Effects On Bone Metabomentioning

confidence: 99%

The Impact of Glucagon-Like Peptide-1 on Bone Metabolism and Its Possible Mechanisms

et al. 2017

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The impact of antidiabetic drugs on bone metabolism is drawing increasing attention due to the discovery of a correlation between type 2 diabetes mellitus (T2DM) and osteoporosis. Glucagon-like peptide-1 (GLP-1) receptor agonists are a novel and promising class of drugs for T2DM, which may also have clinical applications in bone tissue disorders. This review examines the impact of GLP-1 on bone metabolism, including enhancement of bone mineral density and improvement of bone quality. However, the precise effect of GLP-1 on fracture risk has not been unambiguously defined. This review also summarizes our current understanding of the mechanisms by which GLP-1 affects bone metabolism. GLP-1 may act on bone by promoting bone formation, inhibiting bone resorption, and affecting the coordination of the two processes. We describe molecular pathways and proteins, such as Wnt and calcitonin, that are associated with GLP-1 and bone tissue. The specific processes and related molecular mechanisms of the effects of GLP-1 on bone metabolism need to be further explored and clarified.

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“…Metabolic syndrome and osteoporosis are medical conditions that must not be overlooked, since both may lead to serious problems in the aged (1). Metabolic syndrome is characterized by abdominal obesity, impaired glucose tolerance, hypertension and dyslipidemia (2).…”

Section: Introductionmentioning

confidence: 99%

The Hyperglycemia and Hyperketonemia Impaired Bone Microstructures: A Pilot Study in Rats

Zhou

Xie

et al. 2020

Front. Endocrinol.

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Though diabetes mellitus (DM) is one of the known causes of osteoporosis, it is also realized that ketogenic diet (KD), an effective regimen for epilepsy, impairs bone microstructures. However, the similarities and differences of effects between these two factors are still unknown. The purpose of this study is to identify different effects between hyperglycemia and hyperketonemia, which are manifestations of DM and KD, on bone in rats. Thirty male Sprague-Dawley rats were randomly divided into three groups: the sham, DM, and KD groups. Hyperglycemia was achieved by intravenous injection of streptozotocin in DM group, while hyperketonemia was induced by application of ketogenic diet (carbohydrates-to-fat as 1:3) in KD group. The body weight, blood ketone body, and blood glucose were recorded, and the bone turnover markers, bone length, bone microstructures, bone biomechanics and histomorphology were measured after 12 weeks intervention. Compared with the control and KD groups, a significant body weight loss was found in the DM group, and the bone lengths of tibia and femur of the group were shortened. The blood glucose and blood ketone were noticeably increased in the DM and KD rats, respectively. Microstructures and properties of cancellous bone were significantly deteriorated in both the DM and KD groups compared with the sham group, as the bone volumes were decreased and the bone trabecula structures were disturbed. Meanwhile, the thickness and strength of cortical bone was reduced more in the DM group than those in the sham and KD groups. The HE staining showed that bone trabecula was significantly decreased in both the DM and KD groups, and more adipose tissue was observed in the KD rats. The activity of osteoblasts was decreased more in both the KD and DM groups than that in the sham group, while the activity of osteoclasts of the two groups was remarkably increased. The present study indicates that both hyperglycemia and hyperketonemia have adverse effects on bone. Therefore, it is worth paying more attention to the bone status of patients with hyperglycemia and hyperketonemia in clinic.

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Relationships Among the Metabolic Syndrome, Bone Mineral Density, Bone Turnover Markers, and Hyperglycemia

Cited by 17 publications

References 26 publications

Association between basal metabolic function and bone metabolism in postmenopausal women with type 2 diabetes

Association between basal metabolic function and bone metabolism in postmenopausal women with type 2 diabetes

The Impact of Glucagon-Like Peptide-1 on Bone Metabolism and Its Possible Mechanisms

The Hyperglycemia and Hyperketonemia Impaired Bone Microstructures: A Pilot Study in Rats

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