Relationships Among Red Cell Distribution Width, Anemia, and Interleukin-6 in Adult Congenital Heart Disease

Miyamoto, Kenji; Inai, Kei; Takeuchi, Daiji; Shinohara, Tokuko; Nakanishi, Toshio

doi:10.1253/circj.cj-14-1296

Cited by 49 publications

(52 citation statements)

References 32 publications

(15 reference statements)

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“…The red blood cell distribution width (RDW) is a routinely useful index to explore the etiology of anemia, and the recent studies have revealed that RDW is a diagnostic and prognostic predictor of various non-hematology diseases. [51][52][53] In our study, chronic use of cannabinoids is related to an increase in inflammatory cells, especially neutro- in previous studies. 45 We eliminated this confounding factor as the strength of the study; but we admit that there may be other confounding factors such as nutritional effects, toxic effects of combined additional chemicals, patients' life style etc.…”

Section: **supporting

confidence: 64%

“…The red blood cell distribution width (RDW) is a routinely useful index to explore the etiology of anemia, and the recent studies have revealed that RDW is a diagnostic and prognostic predictor of various non‐hematology diseases . In our study, chronic use of cannabinoids is related to an increase in inflammatory cells, especially neutrophils and this immune activity may cause high RDW values that show early signs of anemia and other comorbidity.…”

Section: Discussionmentioning

confidence: 73%

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Alterations of the hematologic cells in synthetic cannabinoid users

Güzel

Yazıcı

et al. 2017

Clinical Laboratory Analysis

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Our data suggested that chronic use of cannabinoids can lead to deterioration of hematopoietic cells. Chronic use of cannabinoids was consistent with subthreshold/subclinical megaloblastic anemia with iron deficiency. Inflammatory cells, especially neutrophil and monocyte counts were higher in SG compared to CG. Thus, recovery of subclinical hematological parameters should be considered in cannabis use disorder patients.

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Section: **supporting

confidence: 64%

“…The red blood cell distribution width (RDW) is a routinely useful index to explore the etiology of anemia, and the recent studies have revealed that RDW is a diagnostic and prognostic predictor of various non‐hematology diseases . In our study, chronic use of cannabinoids is related to an increase in inflammatory cells, especially neutrophils and this immune activity may cause high RDW values that show early signs of anemia and other comorbidity.…”

Section: Discussionmentioning

confidence: 73%

Alterations of the hematologic cells in synthetic cannabinoid users

Güzel

Yazıcı

et al. 2017

Clinical Laboratory Analysis

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“…RDW is a means of evaluating the variability in size of erythrocytes and has been used widely in the differential diagnosis of anemia (2). PDW is measure of variation in platelet size, which may be an indicator of active platelet release (3).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic values of red cell distribution width, platelet distribution width and neutrophil-lymphocyte count ratio for sepsis

Zhang

Chen

Lan

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. The aim of this study was to evaluate the diagnostic efficiency of red blood cell distribution width (RDW), platelet distribution width (PDW), the neutrophil-lymphocyte count ratio (NLCR), procalcitonin (PCT) and C-reactive protein (CRP) for the prediction of sepsis. A total of 120 consecutive patients who underwent blood culture testing were included. The PCT and CRP levels, and RDW, PDW and NLCR percentages were determined and compared between patients with positive blood cultures and those without. The PCT, CRP, RDW, PDW and NLCR values were significantly higher in patients with positive blood culture compared with those without. PCT and NLCR each had a high diagnostic performance for the prediction of sepsis, with an area under the curve (AUC) for sepsis of 0.829 and 0.718, respectively. A combination of RDW, PDW and NLCR also exhibited a good diagnostic performance for sepsis (AUC, 0.704). NLCR is easily obtained by automated hematological analysis. Moreover, NLCR was found to have a high diagnostic efficiency for the prediction of sepsis, with greater sensitivity and accuracy than CRP. In conclusion, PCT exhibited the optimal diagnostic performance among the tested markers. The combination of the three parameters of RDW, PDW and NLCR, demonstrated a high diagnostic performance similar to that of PCT.

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“…Patients with malignant diseases often have chronic inflammation and poor nutritional status. Some studies reported that elevated RDW was correlated with higher IL-6 [23] and erythrocyte sedimentation rate (ESR), as well as high-sensitivities of C-reactive protein (CRP), leukocytes, neutrophils, fibrinogen, and lower Hb [24,25]. Further research supports RDW being associated with erythropoietin (EPO)[26], ALB [27]{Vayá, 2015 #36;G, 2009 #37;Periša, 2015 #13}, iron, folate and vitamin B12 [28].…”

Section: Discussionmentioning

confidence: 99%

Red blood cell distribution width and platelet counts are independent prognostic factors and improve the predictive ability of IPI score in diffuse large B-cell lymphoma patients

Xia

Zheng

et al. 2019

Preprint

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Background: Elevated red blood cell distribution width (RDW) and decreased platelet count (PLT) can be clinically relevant to the prognosis in cancer patients . However, their prognostic values in patients with diffuse large B-cell lymphoma (DLBCL) need to be further explored. Methods: Healthy donors (n=130) and patients with DLBCL (n=349) were included and evaluated retrospectively in this study.The prognostic influence of clinical and pathological factors including RDW and PLT on overall survival (OS) and progression-free survival (PFS) were studied by Kaplan-Meier curves . To evaluate the independent prognostic relevance of RDW and PLT, univariate and multivariate Cox proportional hazards regression models were applied. The adjusted IPI model was established based on the results of multivariate analysis, and verified by Harrell's C statistical analysis. Results: Kaplan-Meier curves indicated that an elevated RDW value and thrombocytopenia are poor factors for OS (P<0.001, P=0.006) and PFS (P=0.003, P<0.001) in DLBCL patients. Multivariate analysis confirmed that elevated RDW value (HR=2.026, 95%CI= 1.263-3.250, P=0.003) and decreased PLT count (HR =1.749, 95%CI=1.010-3.028, P=0.046) were both independent prognostic factors. The c-index of IPI and NCCN-IPI were increased when RDW level and PLT were supplemented in our cohort. Conclusions:Our study shows that elevated RDW level and decreased PLT are independent poor prognostic factors in newly diagnosed DLBCL patients. Adding RDW and PLT to the IPI score may improve its predictive ability, and the adjusted IPI may be more powerful in predicting the survival of DLBCL patients in the rituximab era. Keywords : prognosis, diffuse large B-cell lymphoma ( DLBCL ), red blood cell distribution width (RDW), platelet count (PLT) Background Diffuse large B-cell lymphoma (DLBCL) is the most common type of aggressive lymphomas in hematological malignancies. In the newly diagnosed cases of non-Hodgkin's lymphomas (NHL), about 30% to 40% are DLBCL [1]. Although the survival of DLBCL patients has been greatly improved with the administration of CHOP chemotherapies (cyclophosphamide, doxorubicin, vincristine and prednisolone) with rituximab, there are still about 10-15% of patients suffered from primary refractory disease, and about 20-30% relapsed [2]. addition, age and sex-matched 130 healthy donors (HDs) from the Second Affiliated Hospital of Anhui Medical University were recruited as normal control group. Of the 349 DLBCL patients, we randomly selected 200 patients as the training set, while the remaining patients were assigned to the testing set (n=149) [11]. The demographic characteristics, clinical features and laboratory parameters were obtained from the patient's medical records from both institutions. Retrieved clinical-pathological parameters included gender, age, lactate dehydrogenase (LDH) level, Ann Arbor stage, number of extra nodal sites involvement, Eastern Cooperative Oncology Group performance status (ECOG PS), B symptoms, physical examinations, computed tomog...

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Relationships Among Red Cell Distribution Width, Anemia, and Interleukin-6 in Adult Congenital Heart Disease

Cited by 49 publications

References 32 publications

Alterations of the hematologic cells in synthetic cannabinoid users

Alterations of the hematologic cells in synthetic cannabinoid users

Diagnostic values of red cell distribution width, platelet distribution width and neutrophil-lymphocyte count ratio for sepsis

Red blood cell distribution width and platelet counts are independent prognostic factors and improve the predictive ability of IPI score in diffuse large B-cell lymphoma patients

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