Relationships among psychosocial factors, biomarkers, preeclampsia, and preterm birth in African American women: A pilot

Giurgescu, Carmen; Sanguanklin, Natthananporn; Engeland, Christopher G.; White‐Traut, Rosemary; Park, Chang Gyu; Mathews, Herbert L.; Janusek, Linda Witek

doi:10.1016/j.apnr.2014.09.002

Cited by 37 publications

(38 citation statements)

References 47 publications

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“…In conclusion, this study found a differential methylation in the GR NR3C1 and its co-chaperone HSP90AA1 between preeclamptic and normotensive women, with a possible regulatory role in the response to stress in pregnancy and a possible physiopathological mechanism in PE. These findings contribute to the strengthening of the causal network paradigm previously described by other authors (6,8,(22)(23)(24). Moreover, they support the relation between PE and an unfavorable psychosocial environment, an imbalance in allostatic factors that contribute to a limited placenta formation that can even be present before PE occurence.…”

Section: Discussionsupporting

confidence: 86%

Differential Methylation in Promoter Regions of the Genes NR3C1 and HSP90AA1, Involved in the Regulation, and Bioavailability of Cortisol in Leukocytes of Women With Preeclampsia

et al. 2020

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Introduction: Hypertensive disorders are of interest in obstetrics and gynecology because they are the second place among causes of maternal mortality and a source of complications in the short, mid, and long term. Even if the pathophysiological process behind preeclampsia (PE) is still unknown, stress factors have been revealed to play an important role in the genesis of this pathologic process. Methods: A case-control study was designed with the purpose of determining if there is a differential methylation in NR3C1, HSD11B2, CYP11A1, CRHBP, TEAD3, and HSP90AA1 genes, related to signaling of the hypothalamic-pituitary-adrenal axis, and its regulation on early-onset PE (EOPE). Results: A total of 20 cases and 20 controls were studied by DNA methylation analysis, demonstrating differences among groups in the percentage of methylation of the NR3C1 gene. After a contingency analysis, an odds ratio (OR) for PE of 12.25 was identified for NR3C1 and 9.9 for HSP90AA1 genes. NR3C1, TEAD3, and HSP90AA1 genes showed a positive correlation with the systolic and diastolic blood pressure levels with a p ≤ 0.05. Conclusion: This study found a differential methylation in the glucocorticoid receptor (GR) NR3C1 and its co-chaperone HSP90AA1 in women with PE, with a possible regulatory role in the response to stress in pregnancy and is a likely physiopathological mechanism in PE.

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Section: Discussionsupporting

confidence: 86%

Differential Methylation in Promoter Regions of the Genes NR3C1 and HSP90AA1, Involved in the Regulation, and Bioavailability of Cortisol in Leukocytes of Women With Preeclampsia

et al. 2020

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“…In addition to the stress of being a resident of a deprived neighborhood, through isolation, the environment also can contribute to psychological stress. Lack of social support and use of avoidance coping mechanisms have been related to higher levels of depressive symptoms in pregnant women which is associated with increased risk for preterm birth, even after controlling for other sociodemographic and obstetric factors [ 19 , 20 , 21 , 22 ]. It has been suggested in previous studies that major depression in a susceptible host may lead to alterations in corticotropin-releasing hormone (CRH) levels which act at the placental interface propagating a cascade to preterm birth [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Racial Differences in the Biochemical Effects of Stress in Pregnancy

Ekeke

Méndez

Yanowitz

et al. 2020

IJERPH

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Prenatal stress has been linked to preterm birth via inflammatory dysregulation. We conducted a cross-sectional study on female participants who delivered live, singleton infants at University of Pittsburgh Medical Center Magee Women’s Hospital. Participants (n = 200) were stratified by cumulative risk scores using a combination of individual factors (maternal education, diabetes, hypertension, smoking, relationship status, obesity, depression) and neighborhood deprivation scores. We hypothesized that inflammatory cytokines levels differ by risk group and race. Multiplex analyses of IL-6, IL-8, IL-10, IL-13 and TNF-alpha were run. We found that Black birthing people had more risk factors for chronic stress and had lower levels of IL-6 compared to White birthing people. When stratified by risk group and race, low-risk Black birthing people had lower levels of IL-6 compared to low-risk White birthing people, and high-risk Black birthing people had lower levels of IL-8 compared to high-risk White birthing people. Higher area deprivation scores were associated with lower IL-6 levels. Our results suggest that the relationship between chronic stress and inflammatory cytokines is modified by race. We theorize that Black birthing people encounter repetitive stress due to racism and social disadvantage which may result in stress pathway desensitization and a blunted cytokine response to future stressors.

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“…Giurgescu és mtsai kutatásukban az előbbiekkel összhangban lévő eredmé-nyeket kaptak: a magasabb társas támogatottságról beszámoló nők esetében a proinfl ammatorikus citokinek (IL-2, IL-5, IL-6) alacsonyabb szérumszintje volt kimutatható [27].…”

Section: öSszefoglaló Közleményunclassified

A praeeclampsia pszichoszociális vonatkozásai

2015

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A praeeclampsia kialakulásához egyes esetekben pszichés faktorok is hozzájárulhatnak neuroendokrin és immunoló-giai mechanizmusok közvetítése révén, amelyek közül kiemelhető a hypothalamus-hypophysis-mellékvesekéreg tengely aktivitásának fokozódása és a proinfl ammatorikus citokinek szérumszintjének emelkedése. A praeeclampsia egyes pszichés zavarok előfordulását is megnöveli, a hosszan tartó hospitalizáció, a kontrollvesztés érzése, a koraszülés vagy a magzat egészségkárosodása következtében. Emellett a kórkép tartósan fennálló neurokognitív panaszokat okozhat, amelyek szintén negatívan befolyásolhatják az életminőséget. Tekintettel arra, hogy az anya rossz mentális állapota a terhesség kimenetelét és a magzat fejlődését egyaránt károsan befolyásolhatja, a praeeclampsiás nők számára a pszichológiai segítségnyújtás előnyös lehet. Orv. Hetil., 2015, 156(50), 2028-2034. Kulcsszavak: praeeclampsia, terhesség, depresszió, hypothalamus-hypophysis-mellékvesekéreg tengely, pszichoterápia Psychosocial aspects of preeclampsiaDistress conditions during pregnancy may contribute to the development of preeclampsia by altering functions of the neuroendocrine and immune systems, e.g. activation of the hypothalamic-pituitary-adrenal axis and increase in plasma proinfl ammatory cytokines. Preeclampsia may also precipitate mental health problems due to long-term hospitalization or unpredictable and uncontrollable events such as preterm labor and newborn complications. Besides, preeclampsia may induce persistent neurocognitive complaints with a negative impact on patients' quality of life. As growing evidence indicates that poor maternal mental health has an adverse effect on pregnancy outcome and fetal development, psychosocial interventions may be benefi cial for women with preeclampsia. Rövidítések 11β-HSD2 = 11-béta-hidroxiszteroid-dehidrogenáz-2 izoenzim; ACTH = adrenokortikotrop hormon; CRH = corticotropin releasing hormon; EMDR = eye movement desensitization and reprocessing; HPA = hypothalamus-hypophysis-mellékve-sekéreg tengely; PPD = postpartum depresszió; PTSD = poszttraumás stressz zavar; SNRI = (selective serotonin-norepinephrine reuptake inhibitor) szelektív szerotonin-noradrenalin visszavételgátló; SSRI = (selective serotonin reuptake inhibitor) szelektív szerotoninvisszavétel-gátló A praeeclampsia a terhességek 5-8%-ában fellépő súlyos szövődmény, amely hypertoniában, vizeletfehérje-ürítés-ben nyilvánul meg. Jellemzően a terhesség második vagy harmadik trimeszterében jelentkezik, és az anyai és magzati mortalitás és morbiditás egyik vezető oka világ szerte. A kórkép patogenezise nem teljesen tisztázott. A praeeclampsia kialakulásában a placentáció zavara fontos szerepet játszik a terhesség korai szakaszában [1]. A rossz vérellátású, ezáltal hypoxiás placenta olyan faktorokat

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Relationships among psychosocial factors, biomarkers, preeclampsia, and preterm birth in African American women: A pilot

Cited by 37 publications

References 47 publications

Differential Methylation in Promoter Regions of the Genes NR3C1 and HSP90AA1, Involved in the Regulation, and Bioavailability of Cortisol in Leukocytes of Women With Preeclampsia

Differential Methylation in Promoter Regions of the Genes NR3C1 and HSP90AA1, Involved in the Regulation, and Bioavailability of Cortisol in Leukocytes of Women With Preeclampsia

Racial Differences in the Biochemical Effects of Stress in Pregnancy

A praeeclampsia pszichoszociális vonatkozásai

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