Relationships among personality traits, metabolic syndrome, and metabolic syndrome scores: The Kakegawa cohort study

Ohseto, Hisashi; Ishikuro, Mami; Kikuya, Masahiro; Obara, Taku; Igarashi, Yuko; Takahashi, Satoshi; Kikuchi, Daisuke; Shigihara, Michiko; Yamanaka, Chizuru; Miyashita, Minoru; Mizuno, Satoshi; Nagai, Masato; Matsubara, Hiroko; Sato, Yuki; Metoki, Hirohito; Tachibana, Hirofumi; Maeda‐Yamamoto, Mari; Kuriyama, Shinichi

doi:10.1016/j.jpsychores.2018.01.013

Cited by 14 publications

(13 citation statements)

References 36 publications

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“…Personality traits may be associated with MS, but the conclusion remains controversial, and few studies have been conducted in adult populations; no related cohort study has explored this relationship in adolescents. The results from Japanese adults [20] showed the E score was positively correlated with TGs, FBG and MS components, and the P score was positively correlated with FBG. However, we found the E score in adolescents was negatively correlated with MS, central obesity, SBP and positively correlated with HDL, suggesting the E score may be age dependent and have a different impact on lipid metabolism between adults and adolescents.…”

Section: Discussionmentioning

confidence: 95%

“…Study found children with obesity may experience number of psycho-social problems [19]. A study found that extraverted personality is positively correlated with TG, fasting blood-glucose (FBG) and MS score in adults [20]. However, to our knowledge, there are no studies exploring the correlation between personality traits and MS in adolescent aged 10 ~ Demographic information, SES and prenatal variables included maternal preconception obesity, increased body mass index (BMI) of mother during pregnancy, birth with caesarean section, premature delivery (<37 weeks), birth weight, breastfeeding, gestational hypertension (GH) and gestational diabetes were collected.…”

Section: Introductionmentioning

confidence: 99%

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The Association of Quality of Life and Personality Characteristics with Adolescent Metabolic Syndrome: A Cohort Study

Liang

Zhang

Luo

et al. 2020

Preprint

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Background: Increased prevalence of adolescent metabolic syndrome (MS) is a tracking factor for adulthood cardiovascular diseases. This study aimed to explore the potential relationship of quality of life (QoL) and personality traits with adolescent MS. Methods：1961 participants aged 11.68 years from a cohort study established in 2014 and followed in 2019 was included in Chongqing. Quality of life (QoL) and Eysenck’s personality questionnaire and MS components were collected.Results：The prevalence of adolescent MS is 4.69% (95% confidence interval, 3.84%-5.72%). Higher QoL domain score of physical activity ability (PAA) was a protective factor for both MS and MS score (all P<0.01), which was mainly negatively correlated with central obesity, diastolic blood pressure (DBP) and triglycerides levels, and positively correlated with high density lipoprotein cholesterol (HDL-C) level. Total score of QoL was negatively correlated with triglycerides level and positively correlated with DBP (all P<0.01). High extraversion personality score was a protective factor of adolescent MS (P=0.04) and MS score (P=0.06), which was mainly negatively correlated WC systolic blood pressure and TGs, and positively correlated with HDL-C (all P≤0.01).Conclusions：QoL score and extraversion personality score were independent protective factors for both MS prevalence and MS score, suggesting the community intervention to improve the QoL and psychological health of children is essential.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

The Association of Quality of Life and Personality Characteristics with Adolescent Metabolic Syndrome: A Cohort Study

Liang

Zhang

Luo

et al. 2020

Preprint

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“…Kakegawa cohort study. The Kakegawa cohort study is previously described 32 . Human tissues used in this study were obtained in accordance with the Declaration of Helsinki, and informed consent was obtained from all the patients and healthy volunteers.…”

Section: Methodsmentioning

confidence: 99%

“…The protocol of this study conformed to the relevant statutes and guidelines and was approved by the ethics committee of Tohoku University and Kyushu University. The recruitment and investigation methods in this research have been described previously 32 . In brief, we explained this research to the participants before distributing the research questionnaires.…”

Section: Methodsmentioning

confidence: 99%

Plasma Homocysteine Concentration is Associated with the Expression Level of Folate Receptor 3

Yoshitomi

Nakayama

Yamashita

et al. 2020

Sci Rep

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folic acid and folate receptors (foLRs) play an important role in the downregulation of homocysteine (Hcy), a risk factor of Alzheimer's disease, thrombosis, neuropsychiatric illness and fractures. While several studies have reported that FOLR1 and FOLR2 import folic acid into cells, the role of FOLR3 remains unknown. In this study, we evaluated the impact of FOLR3 on the metabolism of Hcy alongside its protective effect against homocysteine-induced neurotoxicity. To reveal the role of FOLR3, we constructed FOLR3-overexpressed HEK293 cells (FOLR3 + cells) and evaluated cell growth, folic acid intake and Hcy-induced neurotoxicity. Subjects with a high expression of FOLR3 exhibited low levels of plasma homocysteine. The ectopic expression of FOLR3 enhanced cell growth, and the enhanced effect was neutralised by folic acid-deficient media. The Western blot analysis revealed that FOLR3 is secreted into cell supernatant. The folic acid intake of FOLR3 + cells was higher than that of wild-type cells. Supernatant from FOLR3 + cells showed a protective effect on Hcy-induced cytotoxicity. FOLR3 expression in plasma is negatively correlated with plasma homocysteine. our study emphasizes the role of FOLR3 in the intake of folic acid into cells on the one hand and its protective role in Hcy-induced cytotoxicity on the other. Homocysteine (Hcy) is a metabolite of cysteine and is produced from methionine when its terminal methyl group is removed. Hcy is recycled into methionine or converted into cysteine with folic acid 1. High levels of Hcy in serum, above 15 µmol/L, create a medical condition known as hyperhomocysteinemia, which constitutes significant risk factors for several diseases, including Alzheimer's disease, thrombosis, neuropsychiatric illness, cerebrovascular disease, dementia-type disorders and osteoporosis-associated fractures 2-5. In the Japan Collaborative Cohort Study, a large population-based cohort study of middle-aged to elderly subjects on the lifestyle-disease relationship, revealed that people with a high serum homocysteine status (≧15.3 µmol/L) exhibit 4.4 and 3.4 times higher risk of ischaemic stroke and ischaemic heart disease, respectively 6. Hcy is exacerbated by ageing, smoking and oxidative stress, which are known as risk factors for hyperhomocysteinemia 7,8. Taken together, practical approaches to normalise Hcy levels are strongly recommended for persons who prone to developing hyperhomocysteinemia. Folic acid is a water-soluble vitamin and is essential for hematinic processing and cell growth 9,10. Tetrahydrofolic acid, a folic acid derivative, is produced from dihydrofolic acid by dihydrofolate reductase and plays a crucial role in acid and amino acid metabolism. Folic acid converts to 5-methyltetrahydrofolic acid in our body, which contributes to the remethylation of Hcy to methionine. Several epidemiological studies have revealed that folic acid deficiency can increase Hcy levels in the blood 11-13. The folic acid receptors (FOLRs) are involved in uptaking folic acid. FOLR has three isotypes...

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“…Following the results of recent work, we hypothesized that insect-derived peptides would inhibit the activity of enzymes associated with development of the metabolic syndrome. This disease includes a range of cardiovascular disease or type 2 diabetes risk factors including abnormalities in blood glucose levels, increased blood pressure, increased level of triglycerides in the blood, and obesity [10]. According to American Heart Association/National Heart, Lung, and Blood Institute scientific statement to diagnose this syndrome three of the above-mentioned risk factors must be occurred in a patient [11].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of ACE, α-glucosidase, and lipase inhibitory activities of peptides obtained by in vitro digestion of selected species of edible insects

Zielińska

Karaś

Baraniak

et al. 2020

Eur Food Res Technol

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The objective of this study was to examine the inhibition of the activity of enzymes associated with development of the metabolic syndrome by peptide fractions received from simulated gastrointestinal digestion and absorption of heat-treated edible insects. The inhibitory activities of insect-derived peptides were determined against key enzymes relevant to the metabolic syndrome such as the angiotensin-converting enzyme (ACE), pancreatic lipase, and α-glucosidase. After the in vitro absorption process, all hydrolysates showed high inhibitory activity; however, the most effective metabolic syndrome-inhibitory peptides were received after separation on Sephadex G10. The best results were found for peptide fractions obtained from Schistocerca gregaria. The highest enzymes inhibitory activities were obtained for peptide fractions from S. gregaria: boiled for ACE (IC 50 3.95 µg mL −1), baked for lipase (IC 50 9.84 µg mL −1), and raw for α-glucosiadase (IC 50 1.89 µg mL −1) S. gregaria, respectively. Twelve sequences of peptides from the edible insects were identified and their chemical synthesis was carried out as well. Among the synthesized peptides, the KVEGDLK, YETGNGIK, AIGVGAIR, IIAPPER, and FDPFPK sequences of peptides exhibited the highest inhibitory activity. Generally, the heat treatment process applied to edible insects has a positive effect on the properties of the peptide fractions studied.

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Relationships among personality traits, metabolic syndrome, and metabolic syndrome scores: The Kakegawa cohort study

Cited by 14 publications

References 36 publications

The Association of Quality of Life and Personality Characteristics with Adolescent Metabolic Syndrome: A Cohort Study

The Association of Quality of Life and Personality Characteristics with Adolescent Metabolic Syndrome: A Cohort Study

Plasma Homocysteine Concentration is Associated with the Expression Level of Folate Receptor 3

Evaluation of ACE, α-glucosidase, and lipase inhibitory activities of peptides obtained by in vitro digestion of selected species of edible insects

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